CA2710577C - Cristallisation d'iodixanol par broyage - Google Patents

Cristallisation d'iodixanol par broyage Download PDF

Info

Publication number
CA2710577C
CA2710577C CA2710577A CA2710577A CA2710577C CA 2710577 C CA2710577 C CA 2710577C CA 2710577 A CA2710577 A CA 2710577A CA 2710577 A CA2710577 A CA 2710577A CA 2710577 C CA2710577 C CA 2710577C
Authority
CA
Canada
Prior art keywords
iodixanol
crystallization
product
compound
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2710577A
Other languages
English (en)
Other versions
CA2710577A1 (fr
Inventor
Khalid Hussain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/611,956 external-priority patent/US7999134B2/en
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CA2710577A1 publication Critical patent/CA2710577A1/fr
Application granted granted Critical
Publication of CA2710577C publication Critical patent/CA2710577C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention a trait à la fabrication de (1,3-bis(acétamido)- N,N'-bis¬3,5- bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophényl|-2-hydroxypropane)iodixanol, plus précisément à la purification de l'iodixanol par cristallisation par broyage humide.
CA2710577A 2009-07-21 2010-07-20 Cristallisation d'iodixanol par broyage Active CA2710577C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22710609P 2009-07-21 2009-07-21
US61/227,106 2009-07-21
US12/611,956 2009-11-04
US12/611,956 US7999134B2 (en) 2009-07-21 2009-11-04 Crystallization of iodixanol using milling

Publications (2)

Publication Number Publication Date
CA2710577A1 CA2710577A1 (fr) 2011-01-21
CA2710577C true CA2710577C (fr) 2012-09-18

Family

ID=43495950

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2710577A Active CA2710577C (fr) 2009-07-21 2010-07-20 Cristallisation d'iodixanol par broyage

Country Status (1)

Country Link
CA (1) CA2710577C (fr)

Also Published As

Publication number Publication date
CA2710577A1 (fr) 2011-01-21

Similar Documents

Publication Publication Date Title
EP1150943B1 (fr) Elaboration d'iodixanol
CA2575088C (fr) Elaboration d'iodixanol
KR20120105015A (ko) 이오딕사놀의 제조 및 정제
EP1960349B1 (fr) Purification de l'iodixanol
CA2707150C (fr) Reduction de la quantite de solvant dans la cristallisation des films intermediaires pour les agents de contraste radiographique non ioniques
US6153796A (en) Process for iohexol manufacture
EP1966110B1 (fr) Procede de purification de l'iodixanol
EP1641743A1 (fr) Procede de production d'iohexol
EP2277855B1 (fr) Cristallisation d'iodixanol utilisant le broyage
EP2277856B1 (fr) Cristallisation d'iodixanol utilisant des ultrasons
WO1996037460A1 (fr) Procede visant a la production d'un dichlorure d'acide dicarboxylique
CA2710642C (fr) Cristallisation d'iodixanol par ultra-sons
CA2707173C (fr) Cristallisation d'iodixanol dans de l'isopropanol et du methanol
EP2277852B1 (fr) Synthèse d'iodixanol dans l'eau

Legal Events

Date Code Title Description
EEER Examination request
MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 15TH ANNIV.) - STANDARD

Year of fee payment: 15

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250625

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251020

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251021