CA2723904C - Nouveaux modulateurs des recepteurs de la sphingosine phosphate - Google Patents

Nouveaux modulateurs des recepteurs de la sphingosine phosphate Download PDF

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Publication number
CA2723904C
CA2723904C CA2723904A CA2723904A CA2723904C CA 2723904 C CA2723904 C CA 2723904C CA 2723904 A CA2723904 A CA 2723904A CA 2723904 A CA2723904 A CA 2723904A CA 2723904 C CA2723904 C CA 2723904C
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compound
oet
malcondition
pharmaceutically acceptable
alkyl
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CA2723904A
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English (en)
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CA2723904A1 (fr
Inventor
Edward Roberts
Hugh Rosen
Steven Brown
Miguel A. Guerrero
Xuemei Peng
Ramulu Poddutoori
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Scripps Research Institute
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Scripps Research Institute
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Priority claimed from PCT/US2009/003014 external-priority patent/WO2009151529A1/fr
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

La présente invention concerne des composés qui activent un récepteur de la sphingosine-1-phosphate de sous-type 1. Certains composés activent sélectivement le récepteur de sous-type 1 par rapport au récepteur de la sphingosine-1-phosphate de sous-type 3. Linvention concerne également les utilisations et les procédés des composés de linvention pour le traitement détats pathologiques dans lesquels lactivation, lagonisme, linhibition ou lantagonisme de S1P1 est médicalement indiqué.
CA2723904A 2008-05-14 2009-05-14 Nouveaux modulateurs des recepteurs de la sphingosine phosphate Active 2031-05-14 CA2723904C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12760308P 2008-05-14 2008-05-14
US61/127,603 2008-05-14
PCT/US2009/003014 WO2009151529A1 (fr) 2008-05-14 2009-05-14 Nouveaux modulateurs des récepteurs de la sphingosine phosphate

Publications (2)

Publication Number Publication Date
CA2723904A1 CA2723904A1 (fr) 2009-12-17
CA2723904C true CA2723904C (fr) 2017-03-14

Family

ID=43426295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2723904A Active 2031-05-14 CA2723904C (fr) 2008-05-14 2009-05-14 Nouveaux modulateurs des recepteurs de la sphingosine phosphate

Country Status (12)

Country Link
KR (2) KR101582910B1 (fr)
CN (1) CN102118972B (fr)
BR (1) BRPI0912545B1 (fr)
CA (1) CA2723904C (fr)
DK (1) DK2913326T3 (fr)
HR (1) HRP20201316T1 (fr)
HU (1) HUE050411T2 (fr)
IL (1) IL209306A (fr)
LT (1) LT2913326T (fr)
MX (2) MX2010012461A (fr)
SI (1) SI2913326T1 (fr)
ZA (1) ZA201007804B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3782991A1 (fr) 2008-05-14 2021-02-24 The Scripps Research Institute Nouveaux modulateurs de récepteurs de la sphingosine phosphate
WO2015196258A1 (fr) * 2014-06-26 2015-12-30 Monash University Agents d'interaction avec des enzymes
EP4566676A3 (fr) 2016-06-14 2025-11-05 Receptos LLC Formes cristallines de l'ozanimod et de l'ozanimod hydrochloride, et leurs procédés de préparation
CN109563059A (zh) * 2016-08-19 2019-04-02 苏州科睿思制药有限公司 奥扎莫德的晶型及其制备方法
CN108137516A (zh) 2016-09-14 2018-06-08 杭州领业医药科技有限公司 奥扎莫德的晶型、其制备方法及药物组合物
WO2018050091A1 (fr) * 2016-09-14 2018-03-22 苏州科睿思制药有限公司 Forme cristalline du chlorhydrate de l'ozanimod et son procédé de préparation
CN106749213B (zh) * 2016-11-25 2019-07-02 济南大学 一种具有1,2,4-恶二唑结构的吲哚衍生物及制备方法和在制备抗菌药物中的应用
JP7252908B2 (ja) * 2017-06-14 2023-04-05 トレベナ・インコーポレイテッド Ｓ１ｐ１活性を調節するための化合物およびその使用法
EP3677575A4 (fr) 2017-08-31 2020-07-15 Crystal Pharmaceutical (Suzhou) Co., Ltd. Forme cristalline du chlorhydrate d'ozanimod et procédé de préparation correspondant
CN107827837B (zh) * 2017-11-21 2021-09-24 苏州朗科生物技术股份有限公司 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用
KR102882404B1 (ko) * 2022-10-28 2025-11-06 (주)케이메디켐 신규 옥사디아졸 유도체, 이의 제조방법 및 이를 포함하는 인지기능 개선용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60335827D1 (de) * 2002-12-20 2011-03-03 Merck Sharp & Dohme 1-(amino)indane als edg-rezeptoragonisten
PL2003132T3 (pl) * 2006-04-03 2014-10-31 Astellas Pharma Inc Pochodne oksadiazolu jako agoniści S1P1

Also Published As

Publication number Publication date
KR101582910B1 (ko) 2016-01-08
MX2010012461A (es) 2013-07-02
ZA201007804B (en) 2012-01-25
KR20110010777A (ko) 2011-02-07
BRPI0912545A2 (pt) 2021-04-13
SI2913326T1 (sl) 2020-11-30
IL209306A (en) 2017-02-28
MX379538B (es) 2025-03-10
IL209306A0 (en) 2011-01-31
CN102118972B (zh) 2015-06-10
CN102118972A (zh) 2011-07-06
KR20150064245A (ko) 2015-06-10
BRPI0912545B1 (pt) 2022-02-01
HUE050411T2 (hu) 2020-12-28
HRP20201316T1 (hr) 2020-11-27
LT2913326T (lt) 2020-09-10
DK2913326T3 (da) 2020-08-17
CA2723904A1 (fr) 2009-12-17

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