CA2729546A1 - Composes et compositions en tant qu'inhibiteurs de kinase - Google Patents

Composes et compositions en tant qu'inhibiteurs de kinase Download PDF

Info

Publication number: CA2729546A1
Authority: CA; Canada
Prior art keywords: 6alkyl; compound; methyl; halo; pyrazol
Prior art date: 2008-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2729546A

Other languages

English (en)

Inventor

Thomas H. Marsilje, Iii

Wenshuo Lu

Bei Chen

Xiaohui He

Songchun Jiang

Kunyong Yang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

IRM LLC

Original Assignee

IRM LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-25

Filing date

2009-06-24

Publication date

2009-12-30

2009-06-24 Application filed by IRM LLC filed Critical IRM LLC

2009-12-30 Publication of CA2729546A1 publication Critical patent/CA2729546A1/fr

Status Abandoned legal-status Critical Current

Links

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CHZPLAKGFHZPMO-UHFFFAOYSA-N tert-butyl 4-(6-amino-4-methylpyridin-3-yl)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC1=CC(N)=NC=C1C1=CCN(C(=O)OC(C)(C)C)CC1 CHZPLAKGFHZPMO-UHFFFAOYSA-N 0.000 description 1
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BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
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XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 description 1
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DPUOLQHDNGRHBS-MDZDMXLPSA-N trans-Brassidic acid Chemical compound CCCCCCCC\C=C\CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-MDZDMXLPSA-N 0.000 description 1
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IUCJMVBFZDHPDX-UHFFFAOYSA-N tretamine Chemical compound C1CN1C1=NC(N2CC2)=NC(N2CC2)=N1 IUCJMVBFZDHPDX-UHFFFAOYSA-N 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
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PXSOHRWMIRDKMP-UHFFFAOYSA-N triaziquone Chemical compound O=C1C(N2CC2)=C(N2CC2)C(=O)C=C1N1CC1 PXSOHRWMIRDKMP-UHFFFAOYSA-N 0.000 description 1
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125000001425 triazolyl group Chemical group 0.000 description 1
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229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
229930013292 trichothecene Natural products 0.000 description 1
150000003327 trichothecene derivatives Chemical class 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
229960001670 trilostane Drugs 0.000 description 1
KVJXBPDAXMEYOA-CXANFOAXSA-N trilostane Chemical compound OC1=C(C#N)C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@]32O[C@@H]31 KVJXBPDAXMEYOA-CXANFOAXSA-N 0.000 description 1
NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
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HDZZVAMISRMYHH-LITAXDCLSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O HDZZVAMISRMYHH-LITAXDCLSA-N 0.000 description 1
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GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
229960002066 vinorelbine Drugs 0.000 description 1
CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
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FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2729546A 2008-06-25 2009-06-24 Composes et compositions en tant qu'inhibiteurs de kinase Abandoned CA2729546A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US7558308P	2008-06-25	2008-06-25
US61/075,583		2008-06-25
PCT/US2009/048509 WO2009158431A2 (fr)	2008-06-25	2009-06-24	Composés et compositions en tant qu’inhibiteurs de kinase

Publications (1)

Publication Number	Publication Date
CA2729546A1 true CA2729546A1 (fr)	2009-12-30

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ID=41076758

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2729546A Abandoned CA2729546A1 (fr)	2008-06-25	2009-06-24	Composes et compositions en tant qu'inhibiteurs de kinase

Country Status (11)

Country	Link
EP (1)	EP2331526A2 (fr)
JP (1)	JP2011526291A (fr)
KR (1)	KR20110020940A (fr)
CN (1)	CN102203083A (fr)
AU (1)	AU2009262198B2 (fr)
BR (1)	BRPI0914545A2 (fr)
CA (1)	CA2729546A1 (fr)
EA (1)	EA201100078A1 (fr)
MX (1)	MX2010014568A (fr)
UA (1)	UA101057C2 (fr)
WO (1)	WO2009158431A2 (fr)

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EP2464633A1 (fr)	2009-08-14	2012-06-20	Boehringer Ingelheim International GmbH	Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine
EP2544672A1 (fr)	2010-03-09	2013-01-16	OSI Pharmaceuticals, LLC	Thérapie anticancéreuse combinatoire
US8987307B2 (en)	2011-03-03	2015-03-24	Hoffmann-La Roche Inc.	3-amino-pyridines as GPBAR1 agonists
CN103958498B (zh) *	2011-11-29	2016-09-07	霍夫曼-拉罗奇有限公司	作为lrrk2调节剂的氨基嘧啶衍生物
BR112015010221B1 (pt)	2012-11-06	2022-09-13	Shanghai Fochon Pharmaceutical Co., Ltd.	Inibidores de quinase alk, seus usos, composição farmacêutica, e método para fabricação de medicamento
MX394360B (es) *	2013-03-14	2025-03-24	Sumitomo Pharma Oncology Inc	Inhibidores de jak2 y alk2 y metodos para su uso.
AU2015266453C1 (en) *	2014-05-30	2018-09-13	Shanghai Emerald Wellcares Pharmaceutical Co., Ltd	Alk kinase inhibitor, and preparation method and use thereof
EP3523289A1 (fr) *	2016-10-07	2019-08-14	Araxes Pharma LLC	Composés hétérocycliques en tant qu'inhibiteurs de ras et leurs procédés d'utilisation
CN107488148A (zh) *	2017-06-26	2017-12-19	安徽省黄淮兽药有限公司	一种苯丙酰胺类杀虫剂及其制备方法
EP3728228A1 (fr)	2017-12-22	2020-10-28	Ravenna Pharmaceuticals, Inc.	Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la phosphatidylinositol phosphate kinase
TW202045008A (zh) *	2019-02-01	2020-12-16	印度商皮埃企業有限公司	4-取代的異噁唑/異噁唑啉(雜)芳基脒化合物、及其製備與用途
TW202112767A (zh)	2019-06-17	2021-04-01	美商佩特拉製藥公司	作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
CN115515589A (zh) *	2020-02-14	2022-12-23	萨克生物研究学院	Ulk1/2抑制剂及其使用方法
KR20220153582A (ko)	2020-02-14	2022-11-18	솔크 인스티튜트 포 바이올로지칼 스터디즈	마크로시클릭 ulk1/2 억제제

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GB0004890D0 (en) *	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
WO2003026664A1 (fr) *	2001-09-26	2003-04-03	Bayer Corporation	Derives de la 2-phenylamino-4- (5-pyrazolylamino) -pyramidine, inhibiteurs de kinases et en particulier de la kinase src
BRPI0413018B8 (pt) *	2003-07-30	2021-05-25	Rigel Pharmaceuticals Inc	composto, e, uso de um composto
WO2005013996A2 (fr) *	2003-08-07	2005-02-17	Rigel Pharmaceuticals, Inc.	Composes de 2,4-pyrimidinediamine et leurs utilisations comme agents antiproliferants
GB0321710D0 (en) *	2003-09-16	2003-10-15	Novartis Ag	Organic compounds
MXPA06003054A (es) *	2003-09-18	2006-05-31	Novartis Ag	2,4-di-(fenil-amino)-pirimidinas utiles en el tratamiento de trastornos proliferativos.
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BRPI0720264B1 (pt) *	2006-12-08	2022-03-03	Novartis Ag	Compostos e composições como inibidores de proteína cinase
EP2311807B1 (fr) *	2006-12-08	2015-11-11	Novartis AG	Composés et compositions inhibant la protéine kinase
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2009
- 2009-06-24 EA EA201100078A patent/EA201100078A1/ru unknown
- 2009-06-24 BR BRPI0914545A patent/BRPI0914545A2/pt not_active IP Right Cessation
- 2009-06-24 WO PCT/US2009/048509 patent/WO2009158431A2/fr not_active Ceased
- 2009-06-24 EP EP09770964A patent/EP2331526A2/fr not_active Withdrawn
- 2009-06-24 AU AU2009262198A patent/AU2009262198B2/en not_active Expired - Fee Related
- 2009-06-24 MX MX2010014568A patent/MX2010014568A/es not_active Application Discontinuation
- 2009-06-24 CN CN200980129584XA patent/CN102203083A/zh active Pending
- 2009-06-24 JP JP2011516619A patent/JP2011526291A/ja not_active Ceased
- 2009-06-24 UA UAA201104068A patent/UA101057C2/ru unknown
- 2009-06-24 CA CA2729546A patent/CA2729546A1/fr not_active Abandoned
- 2009-06-24 KR KR1020117001749A patent/KR20110020940A/ko not_active Ceased

Also Published As

Publication number	Publication date
WO2009158431A3 (fr)	2010-03-11
EA201100078A1 (ru)	2011-08-30
CN102203083A (zh)	2011-09-28
JP2011526291A (ja)	2011-10-06
UA101057C2 (en)	2013-02-25
AU2009262198B2 (en)	2012-09-27
MX2010014568A (es)	2011-03-29
EP2331526A2 (fr)	2011-06-15
BRPI0914545A2 (pt)	2017-05-23
WO2009158431A2 (fr)	2009-12-30
KR20110020940A (ko)	2011-03-03
AU2009262198A1 (en)	2009-12-30

Legal Events

Date	Code	Title	Description
2010-12-24	EEER	Examination request
2014-06-23	FZDE	Discontinued	Effective date: 20140428

Publication	Publication Date	Title
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US8445505B2 (en)	2013-05-21	Pyrimidine derivatives as kinase inhibitors
EP2311807B1 (fr)	2015-11-11	Composés et compositions inhibant la protéine kinase
AU2009233963B2 (en)	2011-10-06	Compounds and compositions as kinase inhibitors
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AU2012203023A1 (en)	2012-06-14	N-(hetero)aryl, 2- (hetero)aryl-substituted acetamides for use as Wnt signaling modulators