CA2731404A1 - Membranes de polymere bloc permettant d'attenuer un tissu cicatriciel - Google Patents
Membranes de polymere bloc permettant d'attenuer un tissu cicatriciel Download PDFInfo
- Publication number
- CA2731404A1 CA2731404A1 CA2731404A CA2731404A CA2731404A1 CA 2731404 A1 CA2731404 A1 CA 2731404A1 CA 2731404 A CA2731404 A CA 2731404A CA 2731404 A CA2731404 A CA 2731404A CA 2731404 A1 CA2731404 A1 CA 2731404A1
- Authority
- CA
- Canada
- Prior art keywords
- resorbable
- base material
- tissue
- polymer base
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 231100000241 scar Toxicity 0.000 title claims description 10
- 229920005597 polymer membrane Polymers 0.000 title description 3
- 239000012528 membrane Substances 0.000 claims abstract description 140
- 229920000642 polymer Polymers 0.000 claims abstract description 61
- 239000000463 material Substances 0.000 claims description 66
- 229920001223 polyethylene glycol Polymers 0.000 claims description 59
- 239000002202 Polyethylene glycol Substances 0.000 claims description 46
- 230000009467 reduction Effects 0.000 claims description 44
- 239000002356 single layer Substances 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 23
- 229920001577 copolymer Polymers 0.000 claims description 20
- 229920001400 block copolymer Polymers 0.000 claims description 16
- 239000010410 layer Substances 0.000 claims description 15
- 230000002209 hydrophobic effect Effects 0.000 claims description 13
- 230000004888 barrier function Effects 0.000 claims description 12
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 12
- 238000001356 surgical procedure Methods 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- 229920000428 triblock copolymer Polymers 0.000 claims description 10
- 239000007943 implant Substances 0.000 claims description 9
- 230000035876 healing Effects 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 230000012292 cell migration Effects 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 230000024245 cell differentiation Effects 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 claims description 2
- 230000003399 chemotactic effect Effects 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000002297 mitogenic effect Effects 0.000 claims description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 11
- 206010039580 Scar Diseases 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract description 50
- 238000000034 method Methods 0.000 abstract description 31
- 238000002513 implantation Methods 0.000 abstract description 8
- 210000004379 membrane Anatomy 0.000 description 63
- 210000001519 tissue Anatomy 0.000 description 37
- 230000008439 repair process Effects 0.000 description 19
- 238000001125 extrusion Methods 0.000 description 13
- 206010019909 Hernia Diseases 0.000 description 10
- 230000007547 defect Effects 0.000 description 10
- 210000003195 fascia Anatomy 0.000 description 10
- 210000004872 soft tissue Anatomy 0.000 description 9
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 8
- -1 polytetrafluoroethylene Polymers 0.000 description 8
- 229920001553 poly(ethylene glycol)-block-polylactide methyl ether Polymers 0.000 description 7
- 230000037390 scarring Effects 0.000 description 7
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 6
- 229920000954 Polyglycolide Polymers 0.000 description 6
- 239000011148 porous material Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 4
- 208000031737 Tissue Adhesions Diseases 0.000 description 4
- 210000003484 anatomy Anatomy 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 210000004303 peritoneum Anatomy 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000003815 abdominal wall Anatomy 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000006065 biodegradation reaction Methods 0.000 description 3
- 230000003328 fibroblastic effect Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000012876 topography Methods 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000009477 glass transition Effects 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000004003 subcutaneous fat Anatomy 0.000 description 2
- 206010045458 umbilical hernia Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 1
- 208000021970 Abdominal wall defect Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 206010012713 Diaphragmatic hernia Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 206010015677 Exomphalos Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010016997 Forearm fracture Diseases 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 208000006442 Gastroschisis Diseases 0.000 description 1
- 206010021620 Incisional hernias Diseases 0.000 description 1
- 206010024995 Lumbar hernia Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 208000000450 Pelvic Pain Diseases 0.000 description 1
- 229920000432 Polylactide-block-poly(ethylene glycol)-block-polylactide Polymers 0.000 description 1
- 206010060932 Postoperative adhesion Diseases 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 201000010814 Synostosis Diseases 0.000 description 1
- 206010045210 Tympanic Membrane Perforation Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 208000003243 intestinal obstruction Diseases 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000000492 nasalseptum Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 201000003508 omphalocele Diseases 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000003805 procoagulant Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000005532 trapping Effects 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 201000001988 urethral stricture Diseases 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5979508P | 2008-06-08 | 2008-06-08 | |
| US61/059,795 | 2008-06-08 | ||
| PCT/IB2009/006229 WO2010001250A2 (fr) | 2008-06-08 | 2009-06-08 | Membranes de polymere bloc permettant d’attenuer un tissu cicatriciel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2731404A1 true CA2731404A1 (fr) | 2010-01-07 |
Family
ID=41350718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2731404A Abandoned CA2731404A1 (fr) | 2008-06-08 | 2009-06-08 | Membranes de polymere bloc permettant d'attenuer un tissu cicatriciel |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2303351A2 (fr) |
| JP (1) | JP2011523878A (fr) |
| KR (1) | KR101367978B1 (fr) |
| CN (1) | CN102202701A (fr) |
| AU (1) | AU2009265277A1 (fr) |
| CA (1) | CA2731404A1 (fr) |
| MX (1) | MX2010013521A (fr) |
| WO (1) | WO2010001250A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011156552A1 (fr) * | 2010-06-09 | 2011-12-15 | Mast Biosurgery Ag | Accès chirurgical résistant à l'adhésion, renforcement et prothèse de fermeture |
| TWI754876B (zh) * | 2019-12-31 | 2022-02-11 | 財團法人工業技術研究院 | 含藥多層薄膜與其形成方法 |
| KR20250125302A (ko) * | 2024-02-14 | 2025-08-21 | 주식회사 나노바이오시스템 | 고막 재생 패치 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5711958A (en) * | 1996-07-11 | 1998-01-27 | Life Medical Sciences, Inc. | Methods for reducing or eliminating post-surgical adhesion formation |
| US6211249B1 (en) * | 1997-07-11 | 2001-04-03 | Life Medical Sciences, Inc. | Polyester polyether block copolymers |
| PT1588675E (pt) * | 2000-03-10 | 2008-02-29 | Mast Biosurgery Ag | Micromembranas barreira reabsorvíveis para atenuação de tecido cicatricial durante a cicatrização |
| CA2419831A1 (fr) * | 2002-02-28 | 2003-08-28 | Macropore Biosurgery, Inc. | Methodes de determination de la croissance osseuse |
| JP2010540003A (ja) * | 2007-08-27 | 2010-12-24 | マスト バイオサージェリー アクチェンゲゼルシャフト | 治癒中の瘢痕組織を減ずるための再吸収性障壁微小膜 |
-
2009
- 2009-06-08 CA CA2731404A patent/CA2731404A1/fr not_active Abandoned
- 2009-06-08 EP EP09772911A patent/EP2303351A2/fr not_active Withdrawn
- 2009-06-08 AU AU2009265277A patent/AU2009265277A1/en not_active Abandoned
- 2009-06-08 KR KR1020117000449A patent/KR101367978B1/ko not_active Expired - Fee Related
- 2009-06-08 MX MX2010013521A patent/MX2010013521A/es unknown
- 2009-06-08 CN CN2009801281438A patent/CN102202701A/zh active Pending
- 2009-06-08 WO PCT/IB2009/006229 patent/WO2010001250A2/fr not_active Ceased
- 2009-06-08 JP JP2011513072A patent/JP2011523878A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010001250A3 (fr) | 2010-08-26 |
| KR20110050617A (ko) | 2011-05-16 |
| MX2010013521A (es) | 2011-05-30 |
| EP2303351A2 (fr) | 2011-04-06 |
| WO2010001250A2 (fr) | 2010-01-07 |
| AU2009265277A1 (en) | 2010-01-07 |
| KR101367978B1 (ko) | 2014-03-06 |
| JP2011523878A (ja) | 2011-08-25 |
| CN102202701A (zh) | 2011-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130610 |