CA2734075C - Compositions pharmaceutiques configurees pour dissuader le fractionnement des formes posologiques - Google Patents
Compositions pharmaceutiques configurees pour dissuader le fractionnement des formes posologiques Download PDFInfo
- Publication number
- CA2734075C CA2734075C CA2734075A CA2734075A CA2734075C CA 2734075 C CA2734075 C CA 2734075C CA 2734075 A CA2734075 A CA 2734075A CA 2734075 A CA2734075 A CA 2734075A CA 2734075 C CA2734075 C CA 2734075C
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- CA
- Canada
- Prior art keywords
- hours
- drug
- dosage form
- composition
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne une composition pharmaceutique orale comprenant un médicament et un ou plusieurs excipients pharmaceutiquement acceptables dans une forme posologique monolithique, la forme posologique étant configurée de telle manière que lorsqu'elle est fractionnée en plus d'un morceau et lorsqu'au moins un des morceaux est administré à un sujet, la Cmax, l'ASC, et/ou le taux de médicament libéré après l'administration soient sensiblement les mêmes ou inférieurs et le Tmax soit supérieur par rapport à la Cmax, à l'ASC, au taux de médicament libéré, et/ou au Tmax après l'administration de : (1) une composition comparable, sous une forme posologique intacte et renfermant la même de dose de médicament, au ou aux morceaux administrés; (2) une composition médicamenteuse bioéquivalente, sous une forme posologique intacte et renfermant la même de dose de médicament, au ou aux morceaux administrés; et (3) un morceau fractionné d'une composition médicamenteuse bioéquivalente, le morceau fractionné comprenant une dose de médicament égale à la dose du morceau administré de la composition orale. La présente invention concerne également des procédés de fabrication et des procédés d'utilisation cette composition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2008/072914 | 2008-08-12 | ||
| PCT/US2008/072914 WO2009023672A2 (fr) | 2007-08-13 | 2008-08-12 | Médicaments résistant aux abus, procédés d'utilisation et de fabrication |
| PCT/US2009/033919 WO2010019279A1 (fr) | 2008-08-12 | 2009-02-12 | Compositions pharmaceutiques configurées pour dissuader le fractionnement des formes posologiques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2734075A1 CA2734075A1 (fr) | 2010-02-18 |
| CA2734075C true CA2734075C (fr) | 2017-04-18 |
Family
ID=41674715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2734075A Active CA2734075C (fr) | 2008-08-12 | 2009-02-12 | Compositions pharmaceutiques configurees pour dissuader le fractionnement des formes posologiques |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2331080A4 (fr) |
| AU (1) | AU2009282376A1 (fr) |
| CA (1) | CA2734075C (fr) |
| WO (1) | WO2010019279A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007048219A2 (fr) | 2005-09-09 | 2007-05-03 | Labopharm Inc. | Composition medicamenteuse a liberation prolongee |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050163843A1 (en) * | 2003-12-31 | 2005-07-28 | Garth Boehm | Alprazolam formulations |
| TWI415635B (zh) * | 2004-05-28 | 2013-11-21 | 必治妥施貴寶公司 | 加衣錠片調製物及製備彼之方法 |
| US20070020339A1 (en) * | 2005-07-20 | 2007-01-25 | Pharmorx Inc. | Compositions and methods for controlling abuse of medications |
| AU2008286914B2 (en) * | 2007-08-13 | 2014-10-02 | Ohemo Life Sciences Inc. | Abuse resistant drugs, method of use and method of making |
-
2009
- 2009-02-12 CA CA2734075A patent/CA2734075C/fr active Active
- 2009-02-12 AU AU2009282376A patent/AU2009282376A1/en not_active Abandoned
- 2009-02-12 WO PCT/US2009/033919 patent/WO2010019279A1/fr not_active Ceased
- 2009-02-12 EP EP09806994A patent/EP2331080A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2331080A4 (fr) | 2012-11-07 |
| EP2331080A1 (fr) | 2011-06-15 |
| WO2010019279A8 (fr) | 2011-03-17 |
| AU2009282376A1 (en) | 2010-02-18 |
| WO2010019279A1 (fr) | 2010-02-18 |
| CA2734075A1 (fr) | 2010-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140204 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 16TH ANNIV.) - STANDARD Year of fee payment: 16 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250122 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20250122 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250122 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 17TH ANNIV.) - STANDARD Year of fee payment: 17 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20251216 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20251216 |