CA2742539C - Disubstituted phthalazine hedgehog pathway antagonists - Google Patents

Disubstituted phthalazine hedgehog pathway antagonists Download PDF

Info

Publication number: CA2742539C
Authority: CA; Canada
Prior art keywords: cancer; fluorophenyl; fluoro; phthalazin; pharmaceutically acceptable
Prior art date: 2008-11-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2742539A

Other languages

English (en)

French (fr)

Other versions

CA2742539A1 (en

Inventor

Jolie Anne Bastian

Philip Arthur Hipskind

Daniel Jon Sall

Takako Wilson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-03

Filing date

2009-10-22

Publication date

2014-05-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41566219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2742539(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-10-22 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

2010-06-03 Publication of CA2742539A1 publication Critical patent/CA2742539A1/en

2014-05-06 Application granted granted Critical

2014-05-06 Publication of CA2742539C publication Critical patent/CA2742539C/en

Status Expired - Fee Related legal-status Critical Current

2029-10-22 Anticipated expiration legal-status Critical

Links

239000005557 antagonist Substances 0.000 title abstract description 10
230000037361 pathway Effects 0.000 title abstract description 8
241000289669 Erinaceus europaeus Species 0.000 title abstract 2
LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title description 17
-1 1,4-disubstituted phthalazine Chemical class 0.000 claims abstract description 102
206010028980 Neoplasm Diseases 0.000 claims abstract description 15
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 51
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150000003839 salts Chemical class 0.000 claims description 30
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 17
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CA2742539A 2008-11-03 2009-10-22 Disubstituted phthalazine hedgehog pathway antagonists Expired - Fee Related CA2742539C (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11070308P	2008-11-03	2008-11-03
US61/110,703		2008-11-03
PCT/US2009/061573 WO2010062507A1 (en)	2008-11-03	2009-10-22	Disubstituted phthalazine hedgehog pathway antagonists

Publications (2)

Publication Number	Publication Date
CA2742539A1 CA2742539A1 (en)	2010-06-03
CA2742539C true CA2742539C (en)	2014-05-06

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Application Number	Title	Priority Date	Filing Date
CA2742539A Expired - Fee Related CA2742539C (en)	2008-11-03	2009-10-22	Disubstituted phthalazine hedgehog pathway antagonists

Country Status (29)

Country	Link
US (1)	US8404687B2 (2)
EP (1)	EP2364185B1 (2)
JP (1)	JP2012507535A (2)
KR (1)	KR101335746B1 (2)
CN (1)	CN102202737B (2)
AU (1)	AU2009320251C1 (2)
BR (1)	BRPI0921437A2 (2)
CA (1)	CA2742539C (2)
CL (1)	CL2011000979A1 (2)
CO (1)	CO6382123A2 (2)
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CY (1)	CY1114023T1 (2)
DK (1)	DK2364185T3 (2)
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Publication number	Publication date
TN2011000166A1 (en)	2012-12-17
KR101335746B1 (ko)	2013-12-12
EP2364185A1 (en)	2011-09-14
HK1159010A1 (en)	2012-07-27
HRP20130527T1 (en)	2013-07-31
CL2011000979A1 (es)	2011-10-07
EP2364185B1 (en)	2013-05-22
IL211841A0 (en)	2011-06-30
AU2009320251B2 (en)	2013-01-24
PL2364185T3 (pl)	2013-10-31
CR20110202A (es)	2011-06-09
MX2011004683A (es)	2011-06-20
AU2009320251C1 (en)	2013-08-15
JP2012507535A (ja)	2012-03-29
DK2364185T3 (da)	2013-06-03
CY1114023T1 (el)	2016-07-27
MA32726B1 (fr)	2011-10-02
NZ591945A (en)	2012-10-26
CN102202737B (zh)	2014-03-26
CN102202737A (zh)	2011-09-28
EA018931B1 (ru)	2013-11-29
ES2418479T3 (es)	2013-08-14
KR20110066212A (ko)	2011-06-16
US8404687B2 (en)	2013-03-26
EA201170640A1 (ru)	2011-12-30
CO6382123A2 (es)	2012-02-15
SI2364185T1 (sl)	2013-07-31
UA102115C2 (ru)	2013-06-10
US20110190304A1 (en)	2011-08-04
PT2364185E (pt)	2013-07-24
AU2009320251A1 (en)	2010-06-03
BRPI0921437A2 (pt)	2018-10-30
WO2010062507A1 (en)	2010-06-03
ZA201102448B (en)	2012-09-26
PE20110433A1 (es)	2011-07-09
ECSP11011021A (es)	2011-06-30
CA2742539A1 (en)	2010-06-03

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Publication	Publication Date	Title
CA2742539C (en)	2014-05-06	Disubstituted phthalazine hedgehog pathway antagonists
EP2443104B1 (en)	2013-04-17	Disubstituted phthalazine hedgehog pathway antagonists
EP2358698B1 (en)	2012-09-05	Tetrasubstituted pyridazine as hedgehog pathway antagonists
EP2358703B1 (en)	2013-12-25	Tetrasubstituted pyridazines hedgehog pathway antagonists
HK1159010B (en)	2013-09-19	Disubstituted phthalazine hedgehog pathway antagonists
HK1164872B (en)	2013-09-19	Disubstituted phthalazine hedgehog pathway antagonists