CA2743661C - Composes de propenone a disubstitution aryle - Google Patents
Composes de propenone a disubstitution aryle Download PDFInfo
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- CA2743661C CA2743661C CA2743661A CA2743661A CA2743661C CA 2743661 C CA2743661 C CA 2743661C CA 2743661 A CA2743661 A CA 2743661A CA 2743661 A CA2743661 A CA 2743661A CA 2743661 C CA2743661 C CA 2743661C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés de formule (I): dans laquelle R1 et R4 sont OR7, R2 et R3 sont H ou OR7, à condition que lorsque R2 est OR7 alors R3 est H, et lorsque R3 est OR7 alors R2 est H; R5 et R6 sont indépendamment H, OH, ou OR7 à condition que lorsque R5 est OH, R6 nest pas OH; R7 est alkyle, aryle or arylalkyle; le symbole « » représente soit une liaison simple ou une double liaison; ou leur(s) sel(s) ou promédicament(s) pharmaceutiquement acceptable(s). Ces nouveaux composés sont utiles pour le traitement, la prophylaxie, lamélioration, ou la défense contre et/ou la prévention de conditions hormono-dépendantes, le cancer et des maladies et des conditions associées au stress oxydatif.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008905925A AU2008905925A0 (en) | 2008-11-14 | Aryl Di-Substituted Propenone Compounds | |
| AU2008905925 | 2008-11-14 | ||
| PCT/AU2009/001483 WO2010054438A1 (fr) | 2008-11-14 | 2009-11-13 | Composés de propénone à disubstitution aryle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2743661A1 CA2743661A1 (fr) | 2010-05-20 |
| CA2743661C true CA2743661C (fr) | 2017-01-03 |
Family
ID=42169539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2743661A Expired - Fee Related CA2743661C (fr) | 2008-11-14 | 2009-11-13 | Composes de propenone a disubstitution aryle |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8729134B2 (fr) |
| EP (1) | EP2365955B1 (fr) |
| CA (1) | CA2743661C (fr) |
| WO (1) | WO2010054438A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3439642A4 (fr) | 2016-04-06 | 2019-11-13 | Noxopharm Limited | Améliorations de la radiothérapie |
| JP2019513828A (ja) | 2016-04-06 | 2019-05-30 | ノクソファーム リミティド | 改善された薬物動態を有するイソフラボノイド組成物 |
| CA3058500A1 (fr) * | 2016-04-06 | 2017-10-12 | Noxopharm Limited | Administration ciblee de medicament |
| WO2021195698A1 (fr) | 2020-03-30 | 2021-10-07 | Noxopharm Limited | Méthodes de traitement d'une inflammation associée à une infection |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| AUPO203996A0 (en) | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| AUPQ008299A0 (en) | 1999-04-30 | 1999-05-27 | G.J. Consultants Pty Ltd | Isoflavone metabolites |
| EP1177184B1 (fr) | 1999-05-04 | 2004-08-25 | E.I. Du Pont De Nemours And Company | Epoxydes polyfluorees, polymeres associes et procedes |
| CA2512000C (fr) | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Modulateurs selectifs des recepteurs d'oestrogene |
-
2009
- 2009-11-13 WO PCT/AU2009/001483 patent/WO2010054438A1/fr not_active Ceased
- 2009-11-13 CA CA2743661A patent/CA2743661C/fr not_active Expired - Fee Related
- 2009-11-13 EP EP09825656.3A patent/EP2365955B1/fr not_active Ceased
- 2009-11-13 US US13/128,816 patent/US8729134B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110263721A1 (en) | 2011-10-27 |
| US8729134B2 (en) | 2014-05-20 |
| EP2365955B1 (fr) | 2014-12-31 |
| EP2365955A1 (fr) | 2011-09-21 |
| CA2743661A1 (fr) | 2010-05-20 |
| WO2010054438A1 (fr) | 2010-05-20 |
| AU2009316240A1 (en) | 2011-07-07 |
| EP2365955A4 (fr) | 2012-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20141112 |
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| MKLA | Lapsed |
Effective date: 20221114 |