CA2753061C - Nouveaux analogues heteropyrroles agissant sur les recepteurs cannabinoides - Google Patents

Nouveaux analogues heteropyrroles agissant sur les recepteurs cannabinoides Download PDF

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CA2753061C
CA2753061C CA2753061A CA2753061A CA2753061C CA 2753061 C CA2753061 C CA 2753061C CA 2753061 A CA2753061 A CA 2753061A CA 2753061 A CA2753061 A CA 2753061A CA 2753061 C CA2753061 C CA 2753061C
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CA2753061A1 (fr
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Alexandros Makriyannis
Venkata Kiran Vemuri
Teresa Olszewska
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University of Connecticut
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

Cette invention concerne des analogues hétéropyrroles biologiquement actifs comme les imidazoles, les thiazoles, les oxazoles et les pyrazoles capables d'interagir avec les récepteurs cannabinoïdes CB1 et/ou CB2. Les aspects de cette invention concernent des analogues hétéropyrroles servant d'antagonistes des récepteurs CB1 et/ou CB 1, ayant une sélectivité pour le récepteur CB 1 ou CB2, servant d'antagonistes neutres, agissant de préférence sur les récepteurs CB 1 situés dans le système nerveux périphérique, et/ou servant de donneurs oxyde nitrique. L'invention concerne également des préparations pharmaceutiques utilisant les analogues décrits et des méthodes d'administration de quantités thérapeutiquement efficaces des analogues décrits pour obtenir un effet physiologique.
CA2753061A 2009-02-19 2009-02-19 Nouveaux analogues heteropyrroles agissant sur les recepteurs cannabinoides Active CA2753061C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/001054 WO2010104488A1 (fr) 2009-02-19 2009-02-19 Nouveaux analogues hétéropyrroles agissant sur les récepteurs cannabinoïdes

Publications (2)

Publication Number Publication Date
CA2753061A1 CA2753061A1 (fr) 2010-09-16
CA2753061C true CA2753061C (fr) 2016-08-09

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CA2753061A Active CA2753061C (fr) 2009-02-19 2009-02-19 Nouveaux analogues heteropyrroles agissant sur les recepteurs cannabinoides

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EP (1) EP2398323A4 (fr)
CA (1) CA2753061C (fr)
WO (1) WO2010104488A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10053444B2 (en) * 2009-02-19 2018-08-21 University Of Connecticut Cannabinergic nitrate esters and related analogs
KR102001364B1 (ko) 2011-05-13 2019-07-22 어레이 바이오파마 인크. Trka 키나제 저해제로서의 피롤리디닐 유레아 및 피롤리디닐 티오유레아 화합물
WO2014078328A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
WO2014078331A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-(arylalkyle)-n'-pyrazolyle-urée, de thiourée, de guanidine et de cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9822118B2 (en) 2012-11-13 2017-11-21 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
US9981959B2 (en) 2012-11-13 2018-05-29 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078325A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-aryle monocycliques, n'-pyrazolyl-urée, thiourée, guanidine et cyanoguanidine utiles comme inhibiteurs de trka kinase
RU2664541C2 (ru) 2012-11-13 2018-08-20 Эррэй Биофарма Инк. Бициклические соединения мочевины, тиомочевины, гуанидина и цианогуанидина, пригодные для лечения боли
WO2014078378A1 (fr) 2012-11-13 2014-05-22 Array Biopharma Inc. Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
US9809578B2 (en) 2012-11-13 2017-11-07 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
UA116455C2 (uk) 2012-11-13 2018-03-26 Еррей Біофарма Інк. Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka
MY191956A (en) 2014-05-15 2022-07-20 Array Biopharma Inc 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
CA3186341A1 (fr) * 2020-07-27 2022-02-03 Alexandros Makriyannis Nouveaux composes de traitement de la fibrose et d'etats inflammatoires
CA3125847A1 (fr) 2020-07-27 2022-01-27 Makscientific, Llc Procede de fabrication de composes biologiquement actifs et d'intermediaires connexes
US12054480B2 (en) 2020-07-31 2024-08-06 Makscientific, Llc Compounds for treating cannabinoid toxicity and acute cannabinoid overdose

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256727A (en) * 1978-09-18 1981-03-17 The University Of Kentucky Research Foundation Synthesis and use of diagnostic radio-pharmaceuticals comprising radioactive isotopes of bromine with dyes
AU2003209388A1 (en) * 2002-01-29 2003-09-02 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
CA2594488C (fr) * 2005-01-10 2015-04-28 University Of Connecticut Nouveaux analogues d'heteropyrroles agissant sur les recepteurs cannabinoides
US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators

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EP2398323A4 (fr) 2012-08-08
EP2398323A1 (fr) 2011-12-28
CA2753061A1 (fr) 2010-09-16

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