CA2761074A1 - Pyrazolopyrimidines 4-substituees pouvant etre employees en tant qu'inhibiteurs de pkc-theta - Google Patents

Pyrazolopyrimidines 4-substituees pouvant etre employees en tant qu'inhibiteurs de pkc-theta Download PDF

Info

Publication number: CA2761074A1
Authority: CA; Canada
Prior art keywords: independently; compound; halogen; optionally; aliphatic
Prior art date: 2010-05-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2761074A

Other languages

English (en)

Inventor

Juan-Miguel Jimenez

Andrew Miller

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Vertex Pharmaceuticals Inc

Original Assignee

Vertex Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-05-05

Filing date

2010-05-05

Publication date

2011-11-10

2010-05-05 Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc

2011-11-10 Publication of CA2761074A1 publication Critical patent/CA2761074A1/fr

Status Abandoned legal-status Critical Current

Links

239000003112 inhibitor Substances 0.000 title abstract description 18
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229920002554 vinyl polymer Polymers 0.000 description 1
230000008673 vomiting Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
210000002268 wool Anatomy 0.000 description 1
229940053867 xeloda Drugs 0.000 description 1
229940053890 zanosar Drugs 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
229960004276 zoledronic acid Drugs 0.000 description 1
229940061261 zolinza Drugs 0.000 description 1
229940002005 zometa Drugs 0.000 description 1
229940039925 zyprexa Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CA2761074A 2010-05-05 2010-05-05 Pyrazolopyrimidines 4-substituees pouvant etre employees en tant qu'inhibiteurs de pkc-theta Abandoned CA2761074A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/033711 WO2011139273A1 (fr)	2010-05-05	2010-05-05	Pyrazolopyrimidines 4-substituées pouvant être employées en tant qu'inhibiteurs de pkc-thêta

Publications (1)

Publication Number	Publication Date
CA2761074A1 true CA2761074A1 (fr)	2011-11-10

Family

ID=42288734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2761074A Abandoned CA2761074A1 (fr)	2010-05-05	2010-05-05	Pyrazolopyrimidines 4-substituees pouvant etre employees en tant qu'inhibiteurs de pkc-theta

Country Status (6)

Country	Link
EP (1)	EP2566866A1 (fr)
JP (1)	JP2013525481A (fr)
CN (1)	CN102471342A (fr)
AU (1)	AU2010352577A1 (fr)
CA (1)	CA2761074A1 (fr)
WO (1)	WO2011139273A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2015002887A (es) *	2012-09-06	2015-07-06	Plexxikon Inc	Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
US9840503B2 (en)	2015-05-11	2017-12-12	Incyte Corporation	Heterocyclic compounds and uses thereof
WO2017027717A1 (fr)	2015-08-12	2017-02-16	Incyte Corporation	Composés de pyrimidine fusionnés bicycliques utilisés en tant qu'inhibiteurs de tam
AU2016311426B2 (en) *	2015-08-26	2021-05-20	Blueprint Medicines Corporation	Compounds and compositions useful for treating disorders related to NTRK
US10053465B2 (en)	2015-08-26	2018-08-21	Incyte Corporation	Pyrrolopyrimidine derivatives as TAM inhibitors
MX2018006195A (es)	2015-11-19	2018-09-05	Blueprint Medicines Corp	Compuestos y composiciones utiles para el tratamiento de trastornos relacionados con ntrk.
MD3436461T2 (ro)	2016-03-28	2024-05-31	Incyte Corp	Compuși pirolotriazină ca inhibitori TAM
SI3687996T1 (sl)	2017-09-27	2022-04-29	Incyte Corporation	Soli pirolotriazinskih derivatov, ki so uporabne kot zaviralci TAM
MD3813800T2 (ro)	2018-06-29	2025-10-31	Incyte Corp	Formulări de inhibitor al AXL/MER
CN110833559A (zh) *	2018-08-15	2020-02-25	广西梧州制药（集团）股份有限公司	吡唑并嘧啶衍生物在治疗急性肺损伤致肺纤维化的用途
EP4114401A1 (fr)	2020-03-06	2023-01-11	Incyte Corporation	Polythérapie comprenant des inhibiteurs d'axl/mer et de pd-1/pd-l1
BR112023022883A2 (pt)	2021-05-06	2024-01-23	Exscientia Ai Ltd	Moduladores de pkc-teta
EP4333982A1 (fr) *	2021-05-06	2024-03-13	Exscientia Al Limited	Modulateurs de pkc-thêta

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1898243A (zh) *	2003-12-23	2007-01-17	诺瓦提斯公司	二环杂环类p－38激酶抑制剂
KR20070118068A (ko) *	2004-11-23	2007-12-13	레디 유에스 테라퓨틱스 인코포레이티드	신규의 이원 헤테로고리 화합물, 그 제조방법 및 이들을포함하는 조성물
GB0608175D0 (en) *	2006-04-25	2006-06-07	Astex Therapeutics Ltd	Pharmaceutical Compounds
CA2704266A1 (fr) *	2007-11-02	2009-06-11	Vertex Pharmaceuticals Incorporated	Derives de [1h-pyrazolo[3,4-b]pyridin-4-yl]-phenyle ou -pyridin-2-yle en tant qu'inhibiteurs de la proteine kinase c-theta
ES2494365T3 (es) *	2008-01-30	2014-09-15	Genentech, Inc.	Compuestos de pirazolopirimidina que inhiben PI3K y métodos de uso
CN102143746A (zh) *	2008-07-03	2011-08-03	埃克塞利希斯股份有限公司	Cdk 调节剂

2010
- 2010-05-05 EP EP10721216A patent/EP2566866A1/fr not_active Withdrawn
- 2010-05-05 WO PCT/US2010/033711 patent/WO2011139273A1/fr not_active Ceased
- 2010-05-05 CA CA2761074A patent/CA2761074A1/fr not_active Abandoned
- 2010-05-05 AU AU2010352577A patent/AU2010352577A1/en not_active Abandoned
- 2010-05-05 JP JP2013509037A patent/JP2013525481A/ja active Pending
- 2010-05-05 CN CN201080030395XA patent/CN102471342A/zh active Pending

Also Published As

Publication number	Publication date
EP2566866A1 (fr)	2013-03-13
JP2013525481A (ja)	2013-06-20
WO2011139273A1 (fr)	2011-11-10
AU2010352577A1 (en)	2012-01-19
CN102471342A (zh)	2012-05-23

Legal Events

Date	Code	Title	Description
2014-07-01	FZDE	Dead	Effective date: 20140506

Publication	Publication Date	Title
US9029546B2 (en)	2015-05-12	Pyrazolopyridine kinase inhibitors
US8541445B2 (en)	2013-09-24	Pyrazolopyridines
EP2328896B1 (fr)	2013-10-23	Inhibiteurs de pyrazolopyridine kinase tricylique
US20120165368A1 (en)	2012-06-28	Pyrazolopyridine kinase inhibitors
CA2761074A1 (fr)	2011-11-10	Pyrazolopyrimidines 4-substituees pouvant etre employees en tant qu'inhibiteurs de pkc-theta
US20120071494A1 (en)	2012-03-22	Pyrazolopyridine kinase inhibitors
AU2011209644A1 (en)	2012-08-09	Pyrazolopyridine kinase inhibitors
EP2313372A1 (fr)	2011-04-27	Inhibiteurs d aminopyridine kinase
US8895740B2 (en)	2014-11-25	Pyrazolopyrazine kinase inhibitors
US20120172379A1 (en)	2012-07-05	4 substituted pyrazolopyrimidines
CA2787363A1 (fr)	2011-08-04	Inhibiteurs des kinases a base de pyrazolopyrimidine
AU2015201376A1 (en)	2015-04-23	Pyrazolopyridine kinase inhibitors