CA2762338C - Traitement de l'hemorragie subarachnoide et de l'ischemie - Google Patents

Traitement de l'hemorragie subarachnoide et de l'ischemie Download PDF

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Publication number
CA2762338C
CA2762338C CA2762338A CA2762338A CA2762338C CA 2762338 C CA2762338 C CA 2762338C CA 2762338 A CA2762338 A CA 2762338A CA 2762338 A CA2762338 A CA 2762338A CA 2762338 C CA2762338 C CA 2762338C
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CA
Canada
Prior art keywords
agent
seq
subarachnoid hemorrhage
hemorrhage
psd
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Active
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CA2762338A
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English (en)
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CA2762338A1 (fr
Inventor
Michael Tymianski
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NoNO Inc
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NoNO Inc
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Filing date
Publication date
Application filed by NoNO Inc filed Critical NoNO Inc
Priority to AU2012354072A priority Critical patent/AU2012354072B2/en
Priority to SG10201604676WA priority patent/SG10201604676WA/en
Priority to MX2014007031A priority patent/MX364562B/es
Priority to ES12857611T priority patent/ES2731266T3/es
Priority to JP2014546717A priority patent/JP6279483B2/ja
Priority to DK12857611.3T priority patent/DK2800575T3/da
Priority to PCT/IB2012/057259 priority patent/WO2013088382A1/fr
Priority to KR1020147019192A priority patent/KR102114490B1/ko
Priority to SG11201403239UA priority patent/SG11201403239UA/en
Priority to EP12857611.3A priority patent/EP2800575B1/fr
Priority to KR1020207014227A priority patent/KR20200057802A/ko
Priority to CN201280061924.1A priority patent/CN104053448B/zh
Priority to US13/774,053 priority patent/US9241970B2/en
Publication of CA2762338A1 publication Critical patent/CA2762338A1/fr
Priority to IL233103A priority patent/IL233103B/en
Priority to ZA2014/04636A priority patent/ZA201404636B/en
Priority to US14/965,694 priority patent/US10300110B2/en
Priority to JP2017217549A priority patent/JP6741642B2/ja
Priority to US16/381,757 priority patent/US11338015B2/en
Application granted granted Critical
Publication of CA2762338C publication Critical patent/CA2762338C/fr
Priority to JP2020085748A priority patent/JP2020128419A/ja
Priority to US17/524,673 priority patent/US20220175879A1/en
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Abstract

La demande fournit des données provenant dun essai clinique dun inhibiteur PSD-95 chez des sujets subissant une réparation endovasculaire dun anévrisme du système nerveux central ou affectant ce dernier. Les sujets ont été stratifiés selon que lanévrisme sest rompu ou non avant la chirurgie endovasculaire. La rupture est associée à une mortalité plus élevée ou à un affaiblissement accru si un sujet survit. Lessai a fourni la preuve dun bénéfice significatif chez les sujets avec et sans rupture danévrisme avant que la chirurgie endovasculaire ne soit pratiquée. Étonnamment, les sujets qui ont le plus bénéficié du traitement, daprès la pathologie et le résultat neurocognitif, sont ceux dont lanévrisme sest rompu, causant une hémorragie sous-arachnoïdienne. Ces données prouvent quun inhibiteur PSD-95 est bénéfique non seulement dans le cas dun accident ischémique cérébral et dune attaque dapoplexie hémorragique, mais aussi dans les formes dhémorragie du SNC ou affectant celui-ci, en particulier lhémorragie sous-arachnoïdienne.
CA2762338A 2011-12-13 2011-12-15 Traitement de l'hemorragie subarachnoide et de l'ischemie Active CA2762338C (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
CN201280061924.1A CN104053448B (zh) 2011-12-13 2012-12-13 一种蛛网膜下腔出血及局部缺血的治疗方法
MX2014007031A MX364562B (es) 2011-12-13 2012-12-13 Terapia para hemorragia subaracnoidea e isquemia.
ES12857611T ES2731266T3 (es) 2011-12-13 2012-12-13 Terapia para hemorragia subaracnoidea e isquemia
JP2014546717A JP6279483B2 (ja) 2011-12-13 2012-12-13 くも膜下出血および虚血の治療法
DK12857611.3T DK2800575T3 (da) 2011-12-13 2012-12-13 Behandling af subarachnoidalblødning og iskæmi
PCT/IB2012/057259 WO2013088382A1 (fr) 2011-12-13 2012-12-13 Traitement de l'hémorragie subarachnoïde et de l'ischémie
KR1020147019192A KR102114490B1 (ko) 2011-12-13 2012-12-13 지주막하 출혈 및 허혈에 대한 치료법
SG11201403239UA SG11201403239UA (en) 2011-12-13 2012-12-13 Therapy for subarachnoid hemorrhage and ischemia
EP12857611.3A EP2800575B1 (fr) 2011-12-13 2012-12-13 Traitement de l'hémorragie subarachnoïde et de l'ischémie
KR1020207014227A KR20200057802A (ko) 2011-12-13 2012-12-13 지주막하 출혈 및 허혈에 대한 치료법
AU2012354072A AU2012354072B2 (en) 2011-12-13 2012-12-13 Therapy for subarachnoid hemorrhage and ischemia
SG10201604676WA SG10201604676WA (en) 2011-12-13 2012-12-13 Therapy for subarachnoid hemorrhage and ischemia
US13/774,053 US9241970B2 (en) 2011-12-13 2013-02-22 Therapy for subarachnoid hemorrhage and ischemia
IL233103A IL233103B (en) 2011-12-13 2014-06-12 Peptide substances that prevent the binding of psd-95 to the nmdar2 subunit, and their uses in the treatment of subarachnoid hemorrhage and ischemia
ZA2014/04636A ZA201404636B (en) 2011-12-13 2014-06-24 Therapy for subarachnoid hemorrhage and ischemia
US14/965,694 US10300110B2 (en) 2011-12-13 2015-12-10 Therapy for subarachnoid hemorrhage and ischemia
JP2017217549A JP6741642B2 (ja) 2011-12-13 2017-11-10 くも膜下出血および虚血の治療法
US16/381,757 US11338015B2 (en) 2011-12-13 2019-04-11 Therapy for subarachnoid hemorrhage and ischemia
JP2020085748A JP2020128419A (ja) 2011-12-13 2020-05-15 くも膜下出血および虚血の治療法
US17/524,673 US20220175879A1 (en) 2011-12-13 2021-11-11 Therapy for subarachnoid hemorrhage and ischemia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161570264P 2011-12-13 2011-12-13
US61/570,264 2011-12-13

Publications (2)

Publication Number Publication Date
CA2762338A1 CA2762338A1 (fr) 2013-06-13
CA2762338C true CA2762338C (fr) 2019-12-03

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Application Number Title Priority Date Filing Date
CA2762338A Active CA2762338C (fr) 2011-12-13 2011-12-15 Traitement de l'hemorragie subarachnoide et de l'ischemie

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CA (1) CA2762338C (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114502169A (zh) * 2019-07-30 2022-05-13 埃德文斯公司 用于治疗中风的mek抑制剂
CN119108114B (zh) * 2024-09-06 2025-03-11 湖南师范大学 基于认知功能缺陷的大脑连接模式检测方法、装置及设备

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CA2762338A1 (fr) 2013-06-13

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