CA2763817C - Medicaments pegyles reversibles - Google Patents
Medicaments pegyles reversibles Download PDFInfo
- Publication number
- CA2763817C CA2763817C CA2763817A CA2763817A CA2763817C CA 2763817 C CA2763817 C CA 2763817C CA 2763817 A CA2763817 A CA 2763817A CA 2763817 A CA2763817 A CA 2763817A CA 2763817 C CA2763817 C CA 2763817C
- Authority
- CA
- Canada
- Prior art keywords
- fms
- peg
- peg40
- fmoc
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 229940079593 drug Drugs 0.000 title claims abstract description 127
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Landscapes
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Médicaments pégylés réversibles produits par dérivation de groupes fonctionnels libres d'un médicament sélectionné parmi l'amine, l'hydroxyle, le mercapto, le phosphate ou le carboxyle présentant des groupes sensibles à des conditions basiques relativement faibles, notamment le 9-fluorénylméthoxycarbonyle (Fmoc) ou le 2-sulfo-9-fluorénylméthoxycarbonyle (FMS), une fraction PEG étant fixée sur ce groupe. Dans ces médicaments pégylés, la fraction PEG et le résidu de médicament ne sont pas directement liés l'un à l'autre, mais les deux résidus sont plutôt liés à des positions différentes du squelette de la structure Fmoc ou FMS qui est fortement sensible à des bases et qui peut être supprimée dans des conditions physiologiques. De préférence, les médicaments sont des médicaments contenant un groupe amine ou, mieux encore, des peptides et des protéines présentant un poids moléculaire faible ou moyen.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2843439A CA2843439A1 (fr) | 2003-04-08 | 2004-04-08 | Medicaments pegyles reversibles |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46081603P | 2003-04-08 | 2003-04-08 | |
| US60/460,816 | 2003-04-08 | ||
| CA2521784A CA2521784C (fr) | 2003-04-08 | 2004-04-08 | Medicaments pegyles reversibles |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2521784A Division CA2521784C (fr) | 2003-04-08 | 2004-04-08 | Medicaments pegyles reversibles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2843439A Division CA2843439A1 (fr) | 2003-04-08 | 2004-04-08 | Medicaments pegyles reversibles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2763817A1 CA2763817A1 (fr) | 2004-10-21 |
| CA2763817C true CA2763817C (fr) | 2014-05-27 |
Family
ID=45560133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2763817A Expired - Lifetime CA2763817C (fr) | 2003-04-08 | 2004-04-08 | Medicaments pegyles reversibles |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2763817C (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL259827B2 (en) | 2016-01-08 | 2025-07-01 | Ascendis Pharma Growth Disorders As | Controlled-release CNP agonists with low initial NPR-B activity |
| LT3400019T (lt) | 2016-01-08 | 2022-12-12 | Ascendis Pharma Growth Disorders A/S | Cnp provaistai su prie žiedo fragmento prijungtu nešikliu |
| WO2017118707A1 (fr) * | 2016-01-08 | 2017-07-13 | Ascendis Pharma Growth Disorders A/S | Agonistes de cnp à libération contrôlée présentant des effets secondaires réduits |
| NZ743487A (en) | 2016-01-08 | 2023-02-24 | Ascendis Pharma Growth Disorders As | Controlled-release cnp agonists with increased nep stability |
| EP3923906A1 (fr) | 2019-02-11 | 2021-12-22 | Ascendis Pharma Growth Disorders A/S | Formulations pharmaceutiques sèches de conjugués cnp |
-
2004
- 2004-04-08 CA CA2763817A patent/CA2763817C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2763817A1 (fr) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20240408 |