CA2779261C - Anti-inflammatoire et analgesique se liant a la filamine a - Google Patents

Anti-inflammatoire et analgesique se liant a la filamine a Download PDF

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Publication number
CA2779261C
CA2779261C CA2779261A CA2779261A CA2779261C CA 2779261 C CA2779261 C CA 2779261C CA 2779261 A CA2779261 A CA 2779261A CA 2779261 A CA2779261 A CA 2779261A CA 2779261 C CA2779261 C CA 2779261C
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Canada
Prior art keywords
compound
mmol
preparation
added
solution
Prior art date
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Active
Application number
CA2779261A
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English (en)
Other versions
CA2779261A1 (fr
Inventor
Lindsay Burns Barbier
Hoau-Yan Wang
Nan-Horng Lin
Andrei Blasko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pain Therapeutics Inc
Original Assignee
Pain Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/263,257 external-priority patent/US8722851B2/en
Priority claimed from US12/435,284 external-priority patent/US20100279996A1/en
Application filed by Pain Therapeutics Inc filed Critical Pain Therapeutics Inc
Priority claimed from US12/610,091 external-priority patent/US8653068B2/en
Publication of CA2779261A1 publication Critical patent/CA2779261A1/fr
Application granted granted Critical
Publication of CA2779261C publication Critical patent/CA2779261C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un composé ou son sel pharmaceutiquement acceptable, une composition et une méthode à visée analgésique et anti-inflammatoire. Un composé envisagé possède une structure qui correspondant à la Formule A; les substituants des groupes R, d, e, f, k, n, m, D, E, F, K, G, P, Q, W, et Z étant tels que définis dans la description.
CA2779261A 2008-10-31 2009-10-30 Anti-inflammatoire et analgesique se liant a la filamine a Active CA2779261C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12/263,257 US8722851B2 (en) 2007-11-02 2008-10-31 Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A
US12/263,257 2008-10-31
US12/435,284 US20100279996A1 (en) 2009-05-04 2009-05-04 Novel analgesic that binds filamin a
US12/435,284 2009-05-04
US12/610,091 US8653068B2 (en) 2009-10-30 2009-10-30 Filamin A binding anti-inflammatory and analgesic
US12/610,091 2009-10-30
PCT/US2009/062860 WO2010051497A1 (fr) 2008-10-31 2009-10-30 Anti-inflammatoire et analgésique se liant à la filamine a

Publications (2)

Publication Number Publication Date
CA2779261A1 CA2779261A1 (fr) 2010-05-06
CA2779261C true CA2779261C (fr) 2015-03-24

Family

ID=42129311

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2779261A Active CA2779261C (fr) 2008-10-31 2009-10-30 Anti-inflammatoire et analgesique se liant a la filamine a

Country Status (5)

Country Link
EP (1) EP2488177B1 (fr)
AU (1) AU2009308702B2 (fr)
CA (1) CA2779261C (fr)
IL (1) IL219464A (fr)
WO (1) WO2010051497A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
KR101923367B1 (ko) 2011-02-02 2018-12-04 버텍스 파마슈티칼스 인코포레이티드 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
MX2013009393A (es) 2011-02-18 2013-08-29 Vertex Pharma Piperidinamidas cromano-espirociclicas como moduladores de canales de iones.
CN103517910B (zh) 2011-03-14 2016-12-14 沃泰克斯药物股份有限公司 作为离子通道调节剂的吗啉-螺环哌啶酰胺
EP2882428B1 (fr) * 2012-07-13 2019-01-16 Pain Therapeutics, Inc. Méthode pour inhiber la phosphorylation de la protéine tau
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
MA44037B1 (fr) 2016-06-06 2020-03-31 Arena Pharm Inc Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci
SMT202200331T1 (it) * 2016-10-05 2022-09-14 Nsc Therapeutics Gmbh Polimorfi cristallini di un agonista di recettore muscarinico di acetilcolina
WO2020172584A1 (fr) * 2019-02-21 2020-08-27 Pain Therapeutics, Inc. Polymorphes solides d'un composé liant flna et ses sels de chlorhydrate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723442A (en) * 1970-12-31 1973-03-27 Yoshitomi Pharmaceutical 3-oxo-1-oxa-4,8-diazaspiro(4.5)decanes
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
AU2003223093B2 (en) * 2002-05-03 2010-02-04 Israel Institute For Biological Research Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
DE102004014304A1 (de) * 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
DE102004014296A1 (de) * 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8-Triazaspiro[4.5]decan-2-on-Verbindingen
AR057579A1 (es) * 2005-11-23 2007-12-05 Merck & Co Inc Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)

Also Published As

Publication number Publication date
WO2010051497A1 (fr) 2010-05-06
AU2009308702A1 (en) 2012-09-20
IL219464A (en) 2017-05-29
EP2488177B1 (fr) 2016-10-12
IL219464A0 (en) 2012-06-28
EP2488177A4 (fr) 2013-07-03
EP2488177A1 (fr) 2012-08-22
CA2779261A1 (fr) 2010-05-06
AU2009308702B2 (en) 2015-05-28

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