CA2792641C - Synthese de 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones chirales - Google Patents

Synthese de 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones chirales Download PDF

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CA2792641C
CA2792641C CA2792641A CA2792641A CA2792641C CA 2792641 C CA2792641 C CA 2792641C CA 2792641 A CA2792641 A CA 2792641A CA 2792641 A CA2792641 A CA 2792641A CA 2792641 C CA2792641 C CA 2792641C
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alkyl
phenyl
halogen
alkoxy
substituents
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CA2792641A1 (fr
Inventor
Narenda Kumar B. Patel
Bryan T. Forrest
Yong Liu
Sze-Wan Li
Peter Brent Sampson
Louise G. Edwards
Heinz W. Pauls
Graham Cumming
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University Health Network
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University Health Network
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Priority claimed from PCT/CA2010/000518 external-priority patent/WO2010115279A1/fr
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Priority to CA2792641A priority Critical patent/CA2792641C/fr
Priority claimed from PCT/CA2011/000387 external-priority patent/WO2011123947A1/fr
Publication of CA2792641A1 publication Critical patent/CA2792641A1/fr
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention porte sur de nouveaux procédés de synthèse pour la préparation d'un composé cyclopropylindolinone représenté par la formule de structure (A) : (A) ou de son sel pharmaceutiquement acceptable. L'invention porte également sur des intermédiaires de synthèse décrits dans la présente invention.
CA2792641A 2010-04-06 2011-04-06 Synthese de 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones chirales Active CA2792641C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2792641A CA2792641C (fr) 2010-04-06 2011-04-06 Synthese de 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones chirales

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US32132910P 2010-04-06 2010-04-06
US32133210P 2010-04-06 2010-04-06
US61/321,332 2010-04-06
CAPCT/CA2010/000518 2010-04-06
PCT/CA2010/000518 WO2010115279A1 (fr) 2009-04-06 2010-04-06 Inhibiteurs de kinases et procédé de traitement du cancer avec ceux-ci
US61/321,329 2010-04-06
CA2792641A CA2792641C (fr) 2010-04-06 2011-04-06 Synthese de 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones chirales
PCT/CA2011/000387 WO2011123947A1 (fr) 2010-04-06 2011-04-06 Synthèse de 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones chirales

Publications (2)

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CA2792641A1 CA2792641A1 (fr) 2011-10-13
CA2792641C true CA2792641C (fr) 2018-05-01

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113304764B (zh) * 2021-05-08 2023-09-26 大连和源化学科技开发有限公司 一种用于乙酸甲酯氨化脱水制乙腈的催化剂及其制备方法

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CA2792641A1 (fr) 2011-10-13

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