CA2797787C - Metabolic biomarkers of autism - Google Patents
Metabolic biomarkers of autism Download PDFInfo
- Publication number
- CA2797787C CA2797787C CA2797787A CA2797787A CA2797787C CA 2797787 C CA2797787 C CA 2797787C CA 2797787 A CA2797787 A CA 2797787A CA 2797787 A CA2797787 A CA 2797787A CA 2797787 C CA2797787 C CA 2797787C
- Authority
- CA
- Canada
- Prior art keywords
- metabolites
- autism
- autistic
- cellular metabolites
- cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/9426—GABA, i.e. gamma-amino-butyrate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32951510P | 2010-04-29 | 2010-04-29 | |
| US61/329,515 | 2010-04-29 | ||
| PCT/US2011/034654 WO2011139914A1 (en) | 2010-04-29 | 2011-04-29 | Metabolic biomarkers of autism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2797787A1 CA2797787A1 (en) | 2011-11-10 |
| CA2797787C true CA2797787C (en) | 2019-07-09 |
Family
ID=44533446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2797787A Active CA2797787C (en) | 2010-04-29 | 2011-04-29 | Metabolic biomarkers of autism |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9547013B2 (2) |
| EP (1) | EP2564194B1 (2) |
| JP (2) | JP6021187B2 (2) |
| AU (2) | AU2011248464B2 (2) |
| CA (1) | CA2797787C (2) |
| WO (1) | WO2011139914A1 (2) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101322695B1 (ko) * | 2010-08-25 | 2013-10-25 | 주식회사 엘지화학 | 케이블형 이차전지 |
| CA2813606C (en) | 2010-10-07 | 2019-01-22 | Sarkis K. Mazmanian | Probiotic therapies for autism |
| WO2014036182A2 (en) | 2012-08-29 | 2014-03-06 | California Institute Of Technology | Diagnosis and treatment of autism spectrum disorder |
| MX2016000293A (es) * | 2013-07-09 | 2016-06-21 | Stemina Biomarker Discovery Inc | Biomarcadores del trastrono del espectro autista. |
| US20160209428A1 (en) * | 2013-08-21 | 2016-07-21 | The Regents Of The University Of California | Diagnostic and predictive metabolite patterns for disorders affecting the brain and nervous system |
| EP3805756A1 (en) * | 2014-04-08 | 2021-04-14 | Metabolon, Inc. | Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment |
| US20150294081A1 (en) | 2014-04-11 | 2015-10-15 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| US9176113B1 (en) | 2014-04-11 | 2015-11-03 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| CA2966360C (en) | 2014-10-30 | 2023-09-05 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders |
| WO2016069801A1 (en) | 2014-10-30 | 2016-05-06 | California Institute Of Technology | Compositions and methods comprising bacteria for improving behavior in neurodecelopmental disorders |
| GB2556436B (en) | 2015-03-06 | 2022-01-26 | Micromass Ltd | Cell population analysis |
| EP3264989B1 (en) * | 2015-03-06 | 2023-12-20 | Micromass UK Limited | Spectrometric analysis |
| GB2554206B (en) | 2015-03-06 | 2021-03-24 | Micromass Ltd | Spectrometric analysis of microbes |
| EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| JP6421742B2 (ja) | 2015-11-27 | 2018-11-14 | 株式会社デンソー | 車両制御装置 |
| WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
| CN121534089A (zh) | 2016-05-23 | 2026-02-17 | 加州理工学院 | 调节肠微生物群来治疗神经退行性病症 |
| CN107064340A (zh) * | 2017-03-13 | 2017-08-18 | 瀚盟测试科技（天津）有限公司 | 一种检测茶叶中gaba含量的方法 |
| WO2018213204A1 (en) | 2017-05-15 | 2018-11-22 | Axial Biotherapeutics, Inc. | Inhibitors of microbially induced amyloid |
| GB201802116D0 (en) | 2018-02-09 | 2018-03-28 | Univ Warwick | Methods for diagnosing an autistic spectrum disorder |
| CN109030665A (zh) * | 2018-10-08 | 2018-12-18 | 黑龙江大学 | 亲水性液相色谱串联质谱法测定红甜菜中甜菜碱含量的检测方法 |
| US12474327B2 (en) | 2018-11-06 | 2025-11-18 | Stalicla Sa | Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, ADS Phenotype 1 |
| EP4012414A1 (en) | 2020-12-11 | 2022-06-15 | Stalicla S.A. | Diagnosis of autism spectrum disorder phenotype 1 |
| CN113960200B (zh) * | 2021-10-19 | 2023-06-20 | 首都医科大学附属北京儿童医院 | 代谢标志物在诊断儿童adhd合并抽动障碍中的应用 |
| CN114705775B (zh) * | 2022-03-31 | 2023-09-12 | 广东省结核病控制中心 | 一种肺结核评价的血清代谢标志物及其应用 |
| CN115326953A (zh) * | 2022-08-02 | 2022-11-11 | 云谱康(大连)生物科技有限公司 | 一种代谢物组合及应用和检测试剂盒与使用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5686311A (en) * | 1995-06-23 | 1997-11-11 | The Children's Mercy Hospital | Diagnosis of autism and treatment therefor |
| CA2273683A1 (en) * | 1998-06-15 | 1999-12-15 | Ortho-Clinical Diagnostics, Inc. | Diagnostic markers for human disorders |
| JP2006526140A (ja) | 2002-12-24 | 2006-11-16 | バイオサイト インコーポレイテッド | 鑑別診断のためのマーカーおよびその使用方法 |
| GB0504096D0 (en) * | 2005-02-28 | 2005-04-06 | Tipogen As | Method |
| WO2006121952A2 (en) | 2005-05-05 | 2006-11-16 | The Regents Of The University Of California | Diagnostic biomarkers for neurodevelopmental disorders |
| DK2013619T3 (en) * | 2006-04-10 | 2017-12-04 | Wisconsin Alumni Res Found | METHODS FOR USING HUMAN EMBYO STEM CELLS FOR EVALUATION OF THE PHARMACEUTICAL SUBSTANCE AND OTHER CHEMICALS |
| EP2052255A2 (en) | 2006-08-18 | 2009-04-29 | Huntington Medical Research Institutes | Methods of determining levels of free amino acids and dipeptides and diagnosing alzheimer's diseases |
| JP5306345B2 (ja) * | 2007-07-26 | 2013-10-02 | フェノメノーム ディスカバリーズ インク | 自閉症スペクトラム障害の診断、リスク評価、及びモニタリングを行うための方法 |
| US20100248235A1 (en) * | 2007-10-04 | 2010-09-30 | Scherer Stephen W | Biomarkers for autism spectrum disorders |
| WO2009151967A1 (en) * | 2008-05-28 | 2009-12-17 | Georgia Tech Research Corporation | Metabolic biomarkers for ovarian cancer and methods of use thereof |
-
2011
- 2011-04-29 AU AU2011248464A patent/AU2011248464B2/en active Active
- 2011-04-29 CA CA2797787A patent/CA2797787C/en active Active
- 2011-04-29 US US13/098,249 patent/US9547013B2/en active Active
- 2011-04-29 EP EP11721395.9A patent/EP2564194B1/en active Active
- 2011-04-29 JP JP2013508294A patent/JP6021187B2/ja not_active Expired - Fee Related
- 2011-04-29 WO PCT/US2011/034654 patent/WO2011139914A1/en not_active Ceased
-
2015
- 2015-09-28 JP JP2015189529A patent/JP2015231392A/ja active Pending
-
2016
- 2016-07-15 AU AU2016204969A patent/AU2016204969B2/en active Active
- 2016-12-07 US US15/371,692 patent/US10330688B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016204969A1 (en) | 2016-08-04 |
| US20120190055A1 (en) | 2012-07-26 |
| WO2011139914A1 (en) | 2011-11-10 |
| US10330688B2 (en) | 2019-06-25 |
| US20170192019A1 (en) | 2017-07-06 |
| US9547013B2 (en) | 2017-01-17 |
| AU2011248464B2 (en) | 2016-08-11 |
| AU2016204969B2 (en) | 2018-05-17 |
| JP6021187B2 (ja) | 2016-11-09 |
| JP2015231392A (ja) | 2015-12-24 |
| EP2564194B1 (en) | 2019-07-10 |
| JP2013525801A (ja) | 2013-06-20 |
| CA2797787A1 (en) | 2011-11-10 |
| EP2564194A1 (en) | 2013-03-06 |
| AU2011248464A1 (en) | 2012-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160412 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250422 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250422 |