CA2805658C - Polytherapie basee sur des inhibiteurs de mdm2 et efgr - Google Patents
Polytherapie basee sur des inhibiteurs de mdm2 et efgr Download PDFInfo
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- CA2805658C CA2805658C CA2805658A CA2805658A CA2805658C CA 2805658 C CA2805658 C CA 2805658C CA 2805658 A CA2805658 A CA 2805658A CA 2805658 A CA2805658 A CA 2805658A CA 2805658 C CA2805658 C CA 2805658C
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La méthode ci-décrite permet de traiter une maladie, une affection, ou un trouble prolifératif chez un sujet par administration d'une combinaison d'un inhibiteur de la liaison p53-MDM2 et d'un inhibiteur d'EGFR. Divers modes de réalisation des méthodes décrites exercent un effet anti-prolifératif et anti-apoptique synergique, comparé à l'administration d'un de ces agents seul.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36648010P | 2010-07-21 | 2010-07-21 | |
| US61/366,480 | 2010-07-21 | ||
| PCT/US2011/020418 WO2011085129A2 (fr) | 2010-01-06 | 2011-01-06 | Méthodes et compositions pour le développement de médicaments ciblés |
| USPCT/US2011/020418 | 2011-01-06 | ||
| PCT/US2011/020414 WO2011085126A2 (fr) | 2010-01-06 | 2011-01-06 | Méthodes et compositions pour le développement de médicaments ciblés |
| US12/986,146 US8618302B2 (en) | 2010-01-06 | 2011-01-06 | Methods and compositions of targeted drug development |
| US12/986,146 | 2011-01-06 | ||
| USPCT/US2011/020414 | 2011-01-06 | ||
| PCT/US2011/044882 WO2012012653A1 (fr) | 2010-07-21 | 2011-07-21 | Polythérapie basée sur des inhibiteurs de mdm2 et efgr |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2805658A1 CA2805658A1 (fr) | 2012-01-26 |
| CA2805658C true CA2805658C (fr) | 2016-12-13 |
Family
ID=45497182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2805658A Expired - Fee Related CA2805658C (fr) | 2010-07-21 | 2011-07-21 | Polytherapie basee sur des inhibiteurs de mdm2 et efgr |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2596366A4 (fr) |
| CA (1) | CA2805658C (fr) |
| WO (1) | WO2012012653A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9937178B2 (en) | 2011-12-07 | 2018-04-10 | Duke University | Methods of identifying and using MDM2 inhibitors |
| WO2013192423A2 (fr) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Méthodes et compositions utiles pour traiter les maladies impliquant des protéines de la famille bcl-2 avec des dérivés de quinoline |
| US20160038503A1 (en) | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
| US10732182B2 (en) | 2013-08-01 | 2020-08-04 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| JP6538044B2 (ja) | 2013-10-30 | 2019-07-03 | ユートロピクス ファーマシューティカルズ， インコーポレイテッド | 化学療法感受性および化学毒性を判定する方法 |
| EP3388419A1 (fr) * | 2017-04-12 | 2018-10-17 | Leadiant Biosciences SA | Inhibiteurs de gli1 et utilisations associées |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007107545A1 (fr) * | 2006-03-22 | 2007-09-27 | Janssen Pharmaceutica N.V. | Dérivés d'alkylamine cyclique en tant qu'inhibiteurs de l'interaction entre mdm2 et p53 |
| WO2008033747A2 (fr) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Petites molécules multifonctionnelles servant d'agents anti-prolifératifs |
| JP5438008B2 (ja) * | 2007-09-21 | 2014-03-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ＭＤＭ２とｐ５３の間の相互作用の阻害剤 |
| WO2009117484A2 (fr) * | 2008-03-18 | 2009-09-24 | University Of South Florida | Petite molécule inhibitrice d'e2f |
| US8445677B2 (en) * | 2008-10-22 | 2013-05-21 | University Of Southern California | Substituted pyrimidyl guanidine derivatives having anticancer activity |
| US20120295890A1 (en) * | 2009-12-31 | 2012-11-22 | Zacharon Pharmaceutical, Inc. | Glycosaminoglycan inhibitors |
| MX2012007872A (es) * | 2010-01-06 | 2012-10-03 | Joseph P Errico | Metodos y composiciones de desarrollo de farmacos dirigidos. |
-
2011
- 2011-07-21 CA CA2805658A patent/CA2805658C/fr not_active Expired - Fee Related
- 2011-07-21 WO PCT/US2011/044882 patent/WO2012012653A1/fr not_active Ceased
- 2011-07-21 EP EP11810417.3A patent/EP2596366A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2805658A1 (fr) | 2012-01-26 |
| EP2596366A1 (fr) | 2013-05-29 |
| EP2596366A4 (fr) | 2014-04-16 |
| WO2012012653A1 (fr) | 2012-01-26 |
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