CA2807162C - Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale - Google Patents

Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale Download PDF

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Publication number
CA2807162C
CA2807162C CA2807162A CA2807162A CA2807162C CA 2807162 C CA2807162 C CA 2807162C CA 2807162 A CA2807162 A CA 2807162A CA 2807162 A CA2807162 A CA 2807162A CA 2807162 C CA2807162 C CA 2807162C
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CA
Canada
Prior art keywords
resin
peptide
trt
fmoc
thr
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Active
Application number
CA2807162A
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English (en)
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CA2807162A1 (fr
Inventor
Kleomenis K. Barlos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemical and Biopharmaceutical Laboratories of Patras SA
Original Assignee
Chemical and Biopharmaceutical Laboratories of Patras SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Chemical and Biopharmaceutical Laboratories of Patras SA filed Critical Chemical and Biopharmaceutical Laboratories of Patras SA
Priority to CA3186364A priority Critical patent/CA3186364A1/fr
Priority to CA2807162A priority patent/CA2807162C/fr
Publication of CA2807162A1 publication Critical patent/CA2807162A1/fr
Application granted granted Critical
Publication of CA2807162C publication Critical patent/CA2807162C/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente demande concerne des peptides et des peptaibols de pureté élevée pouvant être obtenus par une synthèse peptidique en phase solide à l'aide, comme résine de départ, d'acides hydroxy aminés, des amides d'acides hydroxy aminés, des alcools hydroxy aminés ou de petits peptides contenant des acides hydroxy aminés fixés à des polymères par l'intermédiaire de leur chaîne latérale.
CA2807162A 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale Active CA2807162C (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA3186364A CA3186364A1 (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale
CA2807162A CA2807162C (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2807162A CA2807162C (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3186364A Division CA3186364A1 (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale

Publications (2)

Publication Number Publication Date
CA2807162A1 CA2807162A1 (fr) 2014-08-21
CA2807162C true CA2807162C (fr) 2023-03-21

Family

ID=51386047

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2807162A Active CA2807162C (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale
CA3186364A Pending CA3186364A1 (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3186364A Pending CA3186364A1 (fr) 2013-02-21 2013-02-21 Synthese de peptide en phase solide a l'aide d'attachement de chaine laterale

Country Status (1)

Country Link
CA (2) CA2807162C (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114685614B (zh) * 2020-12-30 2024-07-12 湖北健翔生物制药有限公司 一种阿托西班的固相合成方法
CN114685616B (zh) * 2020-12-31 2024-03-29 哈尔滨三联药业股份有限公司 醋酸曲普瑞林的合成方法

Also Published As

Publication number Publication date
CA2807162A1 (fr) 2014-08-21
CA3186364A1 (fr) 2014-08-21

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