CA2807496C - Analogues carbanucleosidiques 2'-fluoro-substitues pour traitement antiviral - Google Patents

Analogues carbanucleosidiques 2'-fluoro-substitues pour traitement antiviral Download PDF

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Publication number
CA2807496C
CA2807496C CA2807496A CA2807496A CA2807496C CA 2807496 C CA2807496 C CA 2807496C CA 2807496 A CA2807496 A CA 2807496A CA 2807496 A CA2807496 A CA 2807496A CA 2807496 C CA2807496 C CA 2807496C
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Prior art keywords
compound
another aspect
alkyl
inhibitors
hcv
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CA2807496A
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CA2807496A1 (fr
Inventor
Aesop Cho
Choung Kim
Adrian Ray
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Gilead Sciences Inc
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Gilead Sciences Inc
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Priority claimed from US12/885,917 external-priority patent/US7973013B2/en
Priority claimed from US13/050,820 external-priority patent/US8455451B2/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CA2807496A1 publication Critical patent/CA2807496A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des nucléosides à imidazo[1,2-f][1,2,4]triazinyle choisis, des nucléoside-phosphates et des promédicaments de ceux-ci, la position 2' du sucre du nucléoside étant substituée par des substituants halogénés et carbonés. Les composés, les compositions et les procédés de l'invention sont utiles pour le traitement d'infections à virus de la famille de Flaviviridae, en particulier d'infections de type hépatite C provoquées par des souches aussi bien de type de sauvage que mutantes du VHC. Formula (I)
CA2807496A 2010-09-20 2011-03-22 Analogues carbanucleosidiques 2'-fluoro-substitues pour traitement antiviral Active CA2807496C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/885,917 2010-09-20
US12/885,917 US7973013B2 (en) 2009-09-21 2010-09-20 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
US13/050,820 US8455451B2 (en) 2009-09-21 2011-03-17 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
US13/050,820 2011-03-17
PCT/US2011/029441 WO2012039791A1 (fr) 2010-09-20 2011-03-22 Analogues carbanucléosidiques 2'-fluoro-substitués pour traitement antiviral

Publications (2)

Publication Number Publication Date
CA2807496A1 CA2807496A1 (fr) 2012-03-29
CA2807496C true CA2807496C (fr) 2019-01-22

Family

ID=47748238

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2807496A Active CA2807496C (fr) 2010-09-20 2011-03-22 Analogues carbanucleosidiques 2'-fluoro-substitues pour traitement antiviral

Country Status (22)

Country Link
EP (1) EP2619206A1 (fr)
JP (4) JP2013538230A (fr)
KR (1) KR101879887B1 (fr)
CN (1) CN103108876A (fr)
AP (1) AP3699A (fr)
AU (1) AU2011306066B2 (fr)
BR (1) BR112013008017A2 (fr)
CA (1) CA2807496C (fr)
CL (1) CL2013000727A1 (fr)
CO (1) CO6680669A2 (fr)
CR (1) CR20130172A (fr)
EA (1) EA026523B1 (fr)
EC (1) ECSP13012560A (fr)
IL (1) IL225221A0 (fr)
MA (1) MA34593B1 (fr)
MX (1) MX2013003179A (fr)
NZ (1) NZ608070A (fr)
PE (3) PE20230684A1 (fr)
PH (1) PH12013500311B1 (fr)
SG (1) SG188223A1 (fr)
WO (1) WO2012039791A1 (fr)
ZA (1) ZA201301042B (fr)

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Also Published As

Publication number Publication date
PE20230684A1 (es) 2023-04-21
CR20130172A (es) 2013-05-29
KR20130110168A (ko) 2013-10-08
AU2011306066A1 (en) 2013-02-28
CL2013000727A1 (es) 2013-08-23
PE20131165A1 (es) 2013-10-14
AU2011306066B2 (en) 2015-01-29
NZ608070A (en) 2015-11-27
JP2017119726A (ja) 2017-07-06
EP2619206A1 (fr) 2013-07-31
EA201390141A1 (ru) 2013-09-30
EA026523B1 (ru) 2017-04-28
MA34593B1 (fr) 2013-10-02
JP2013538230A (ja) 2013-10-10
CA2807496A1 (fr) 2012-03-29
JP6475280B2 (ja) 2019-02-27
MX2013003179A (es) 2013-04-24
AP3699A (en) 2016-05-31
CO6680669A2 (es) 2013-05-31
PE20171624A1 (es) 2017-11-02
WO2012039791A1 (fr) 2012-03-29
IL225221A0 (en) 2013-06-27
AP2013006767A0 (en) 2013-03-31
BR112013008017A2 (pt) 2016-06-14
ZA201301042B (en) 2014-07-30
PH12013500311A1 (en) 2013-04-22
ECSP13012560A (es) 2013-06-28
KR101879887B1 (ko) 2018-07-18
JP2016074732A (ja) 2016-05-12
SG188223A1 (en) 2013-04-30
PH12013500311B1 (en) 2017-11-08
CN103108876A (zh) 2013-05-15
JP2019014726A (ja) 2019-01-31

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