CA2836827C - Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases - Google Patents

Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases Download PDF

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Publication number
CA2836827C
CA2836827C CA2836827A CA2836827A CA2836827C CA 2836827 C CA2836827 C CA 2836827C CA 2836827 A CA2836827 A CA 2836827A CA 2836827 A CA2836827 A CA 2836827A CA 2836827 C CA2836827 C CA 2836827C
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CA
Canada
Prior art keywords
amino acid
inhibitor
ester
conjugate
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2836827A
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English (en)
Other versions
CA2836827A1 (fr
Inventor
Alan Hornsby Davidson
Alan Hastings Drummond
Lindsey Ann Needham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macrophage Pharma Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Priority claimed from CA2607020A external-priority patent/CA2607020C/fr
Publication of CA2836827A1 publication Critical patent/CA2836827A1/fr
Application granted granted Critical
Publication of CA2836827C publication Critical patent/CA2836827C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La conjugaison covalente dun ester aminé alpha à un modulateur de l'activité dune enzyme intracellulaire cible ou dun récepteur, où le groupe ester du conjugué est hydrolysable par une ou plusieurs enzymes carboxylestérases intracellulaires à lacide correspondant, mène à laccumulation du produit dhydrolyse d'acide carboxylique dans la cellule et permet une modulation améliorée ou prolongée de lenzyme ou du récepteur par rapport au modulateur non conjugué.
CA2836827A 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases Expired - Lifetime CA2836827C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0509226A GB0509226D0 (en) 2005-05-05 2005-05-05 Enzyme and receptor modulation
GB0509226.7 2005-05-05
US68054205P 2005-05-13 2005-05-13
US60/680,542 2005-05-13
CA2607020A CA2607020C (fr) 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2607020A Division CA2607020C (fr) 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases

Publications (2)

Publication Number Publication Date
CA2836827A1 CA2836827A1 (fr) 2006-11-09
CA2836827C true CA2836827C (fr) 2016-05-03

Family

ID=34685158

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2836827A Expired - Lifetime CA2836827C (fr) 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases

Country Status (10)

Country Link
CN (1) CN101171039B (fr)
CA (1) CA2836827C (fr)
DK (1) DK1877098T3 (fr)
ES (2) ES2577433T3 (fr)
GB (1) GB0509226D0 (fr)
NZ (1) NZ561710A (fr)
PT (1) PT1877098E (fr)
SG (1) SG2014007512A (fr)
SI (1) SI1877098T1 (fr)
ZA (1) ZA200708283B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02002505A (es) * 1999-09-08 2004-09-10 Sloan Kettering Inst Cancer Nueva clase de agentes de citodiferenciacion e inhibidores de histona desacetilasa y metodos de utilizacion de los mismos.
EP1677785A1 (fr) * 2003-10-22 2006-07-12 Arpida A/S Derives de benzimidazole et leur application comme inhibiteurs de la peptide-deformylase

Also Published As

Publication number Publication date
ES2577433T3 (es) 2016-07-14
DK1877098T3 (da) 2013-07-08
CN101171039B (zh) 2013-01-23
GB0509226D0 (en) 2005-06-15
SG2014007512A (en) 2014-03-28
SI1877098T1 (sl) 2013-08-30
NZ561710A (en) 2010-08-27
CN101171039A (zh) 2008-04-30
CA2836827A1 (fr) 2006-11-09
PT1877098E (pt) 2013-07-31
ES2415244T3 (es) 2013-07-24
ZA200708283B (en) 2008-10-29

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Effective date: 20131217

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Effective date: 20241106