CA2862980C - Production de diterpene - Google Patents

Production de diterpene

Info

Publication number
CA2862980C
CA2862980C CA2862980A CA2862980A CA2862980C CA 2862980 C CA2862980 C CA 2862980C CA 2862980 A CA2862980 A CA 2862980A CA 2862980 A CA2862980 A CA 2862980A CA 2862980 C CA2862980 C CA 2862980C
Authority
CA
Canada
Prior art keywords
rebaudioside
microorganism
polypeptide
nucleotide sequence
seqid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2862980A
Other languages
English (en)
Other versions
CA2862980A1 (fr
Inventor
Martin Lehmann
Joshua Trueheart
Priscilla Zwartjens
Liang Wu
Viktor Boer
Cornelis Maria Jacobus Sagt
Manoj Kumar
Bernard Meijrink
Marco Alexander Van Den Berg
Adam G. LAWRENCE
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Priority claimed from PCT/EP2013/051262 external-priority patent/WO2013110673A1/fr
Publication of CA2862980A1 publication Critical patent/CA2862980A1/fr
Application granted granted Critical
Publication of CA2862980C publication Critical patent/CA2862980C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne un microorganisme recombinant comprenant une ou plusieurs séquences nucléotidiques codant pour un polypeptide doté d'une activité ent-copalyl pyrophosphate synthase; un polypeptide doté d'une activité ent-kaurène synthase; un polypeptide doté d'une activité ent-kaurène oxydase; et un polypeptide doté d'une activité acide kaurénoïque 13-hydroxylase, l'expression de la ou des séquences nucléotidiques conférant audit microorganisme la capacité de produire au moins du stéviol. Ledit microorganisme recombinant peut également se montrer capable d'exprimer une ou plusieurs UDP-glucosyltransférases de façon à pouvoir produire un ou plusieurs glycosides de stéviol.
CA2862980A 2012-01-23 2013-01-23 Production de diterpene Active CA2862980C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261589683P 2012-01-23 2012-01-23
US61/589,683 2012-01-23
US201261727591P 2012-11-16 2012-11-16
US61/727,591 2012-11-16
PCT/EP2013/051262 WO2013110673A1 (fr) 2012-01-23 2013-01-23 Production de diterpène

Publications (2)

Publication Number Publication Date
CA2862980A1 CA2862980A1 (fr) 2013-08-01
CA2862980C true CA2862980C (fr) 2025-09-16

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