CA2869295A1 - Procedes faisant appel a la methylation de l'adn pour identifier une cellule ou un melange de cellules afin de pronostiquer et de diagnostiquer des maladies et pour effectuer des traitements de reparation cellulaire - Google Patents
Procedes faisant appel a la methylation de l'adn pour identifier une cellule ou un melange de cellules afin de pronostiquer et de diagnostiquer des maladies et pour effectuer des traitements de reparation cellulaire Download PDFInfo
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- CA2869295A1 CA2869295A1 CA2869295A CA2869295A CA2869295A1 CA 2869295 A1 CA2869295 A1 CA 2869295A1 CA 2869295 A CA2869295 A CA 2869295A CA 2869295 A CA2869295 A CA 2869295A CA 2869295 A1 CA2869295 A1 CA 2869295A1
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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- C12Q2600/00—Oligonucleotides characterized by their use
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Abstract
La présente invention concerne des procédés faisant appel à des réseaux de méthylation d'ADN pour identifier une cellule ou un mélange de cellules et pour quantifier les modifications de distribution de cellules dans le sang ou dans les tissus, et pour diagnostiquer, pronostiquer et traiter des maladies, en particulier un cancer. Les procédés utilisent des échantillons fraîchement prélevés et stockés.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161489883P | 2011-05-25 | 2011-05-25 | |
| US61/489,883 | 2011-05-25 | ||
| US201161509644P | 2011-07-20 | 2011-07-20 | |
| US61/509,644 | 2011-07-20 | ||
| US201261585892P | 2012-01-12 | 2012-01-12 | |
| US61/585,892 | 2012-01-12 | ||
| US201261619663P | 2012-04-03 | 2012-04-03 | |
| US61/619,663 | 2012-04-03 | ||
| PCT/US2012/039699 WO2012162660A2 (fr) | 2011-05-25 | 2012-05-25 | Procédés faisant appel à la méthylation de l'adn pour identifier une cellule ou un mélange de cellules afin de pronostiquer et de diagnostiquer des maladies et pour effectuer des traitements de réparation cellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2869295A1 true CA2869295A1 (fr) | 2012-11-29 |
Family
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| CA2869295A Abandoned CA2869295A1 (fr) | 2011-05-25 | 2012-05-25 | Procedes faisant appel a la methylation de l'adn pour identifier une cellule ou un melange de cellules afin de pronostiquer et de diagnostiquer des maladies et pour effectuer des traitements de reparation cellulaire |
Country Status (3)
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|---|---|
| EP (1) | EP2714933A4 (fr) |
| CA (1) | CA2869295A1 (fr) |
| WO (1) | WO2012162660A2 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9561006B2 (en) * | 2008-10-15 | 2017-02-07 | The United States Of America As Represented By The Secretary Of The Navy | Bayesian modeling of pre-transplant variables accurately predicts kidney graft survival |
| EP3382033B1 (fr) * | 2017-03-30 | 2020-08-05 | Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen | Méthode pour déterminer le nombre des cellules sanguines basée sur la méthylation de l'adn |
| DE102017125019B4 (de) | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | PDCD1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere PD1+ Zellen |
| DE102017125013B4 (de) | 2017-10-25 | 2019-10-17 | Epiontis Gmbh | MCC als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere basophiler Granulozyten |
| DE102017125150B4 (de) | 2017-10-26 | 2019-10-10 | Epiontis Gmbh | Endosialin (CD248) als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere naïver CD8+ T-Zellen |
| DE102017125335B4 (de) | 2017-10-27 | 2019-10-17 | Epiontis Gmbh | Amplikon-Region als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere nicht-klassischer Monozyten |
| DE102017126248B4 (de) | 2017-11-09 | 2019-10-17 | Epiontis Gmbh | ERGIC1 als epigenetischer Marker zur Identifizierung von Immunzellen, insbesonderemonozytischem myeloid-abgeleiteten Suppressor-Zellen (mMDSCs) |
| DE102018112644B4 (de) | 2018-05-25 | 2020-06-10 | Epiontis Gmbh | CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen |
| WO2020007951A1 (fr) | 2018-07-05 | 2020-01-09 | Epiontis Gmbh | Méthode épigénétique pour détecter et faire la distinction entre des syndromes ipex et des syndromes de type ipex, en particulier chez les nouveau-nés |
| DE102020108560B4 (de) | 2020-03-27 | 2022-03-03 | Precision For Medicine Gmbh | CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen |
| DE102020111423B4 (de) | 2020-04-27 | 2022-03-03 | Precision For Medicine Gmbh | MYH11/NDE1 Region als epigenetischer Marker für die Identifizierung von Endothel-Vorläuferzellen (EPCs) |
| CA3201466A1 (fr) | 2020-12-14 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Methodes de traitement de troubles metaboliques et de maladies cardiovasculaires avec des inhibiteurs de la sous-unite beta e de l'inhibine (inhbe) |
| CN114703284A (zh) * | 2022-04-15 | 2022-07-05 | 北京莱盟君泰国际医疗技术开发有限公司 | 一种血液游离dna甲基化定量检测方法及其应用 |
| EP4594522A2 (fr) * | 2022-09-27 | 2025-08-06 | Guardant Health, Inc. | Procédés et compositions de quantification d'adn de cellules immunitaires |
| CN116312794B (zh) * | 2023-01-09 | 2023-11-14 | 哈尔滨医科大学 | 一种融合单细胞分析方法的甲基化样本聚类方法 |
| DE102023114015B3 (de) | 2023-05-26 | 2024-09-12 | Precision For Medicine Gmbh | ITGA4 als epigenetischer Marker für die Identifizierung von Immunzellen |
| DE102023114016B3 (de) | 2023-05-26 | 2024-09-12 | Precision For Medicine Gmbh | LAG3 als epigenetischer Marker für die Identifizierung von Immunzellen |
| DE102023114004B3 (de) | 2023-05-26 | 2024-09-12 | Precision For Medicine Gmbh | GATA 3 als epigenetischer Marker zur Identifizierung von Immunzellen |
| DE102023114008B3 (de) | 2023-05-26 | 2024-09-12 | Precision For Medicine Gmbh | CRTH2 (PTGDR2) als epigenetischer Marker zur Identifizierung von Immunzellen |
| WO2024258948A1 (fr) * | 2023-06-12 | 2024-12-19 | Tru Diagnostics, Inc. | Procédé de prédiction de la santé d'un sujet humain |
| CN116949156B (zh) * | 2023-09-19 | 2023-12-08 | 美迪西普亚医药科技(上海)有限公司 | 一种基于核酸变体的通用型检测人t细胞的分析方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1826279T3 (da) * | 2006-02-28 | 2011-09-05 | Charite Universitaetsmedizin | Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet |
| DK2199411T3 (en) * | 2008-12-16 | 2015-08-03 | Epiontis Gmbh | Epigenetic markers for the identification of CD3-positive T lymphocytes |
-
2012
- 2012-05-25 CA CA2869295A patent/CA2869295A1/fr not_active Abandoned
- 2012-05-25 EP EP12789375.8A patent/EP2714933A4/fr not_active Withdrawn
- 2012-05-25 WO PCT/US2012/039699 patent/WO2012162660A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2714933A4 (fr) | 2014-12-31 |
| EP2714933A2 (fr) | 2014-04-09 |
| WO2012162660A2 (fr) | 2012-11-29 |
| WO2012162660A3 (fr) | 2013-03-28 |
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| FZDE | Discontinued |
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