CA2876852A1 - Quantification de la quantite relative d'eau dans le reseau microcapillaire d'un tissu - Google Patents

Quantification de la quantite relative d'eau dans le reseau microcapillaire d'un tissu Download PDF

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CA2876852A1
CA2876852A1 CA2876852A CA2876852A CA2876852A1 CA 2876852 A1 CA2876852 A1 CA 2876852A1 CA 2876852 A CA2876852 A CA 2876852A CA 2876852 A CA2876852 A CA 2876852A CA 2876852 A1 CA2876852 A1 CA 2876852A1
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flow
diffusion
compensated
data
weighting
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CA2876852C (fr
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Daniel Topgaard
Samo LASIC
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Random Walk Imaging AB
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CR Development AB
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56341—Diffusion imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0263—Measuring blood flow using NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/5635—Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56366—Perfusion imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/565—Correction of image distortions, e.g. due to magnetic field inhomogeneities
    • G01R33/56509—Correction of image distortions, e.g. due to magnetic field inhomogeneities due to motion, displacement or flow, e.g. gradient moment nulling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/041—Controlled or regulated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/543—Control of the operation of the MR system, e.g. setting of acquisition parameters prior to or during MR data acquisition, dynamic shimming, use of one or more scout images for scan plane prescription
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Signal Processing (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La présente invention concerne un procédé d'imagerie par résonance magnétique (RM) consistant à : acquérir au moins deux images RM présentant des pondérations de mouvement différentes, provenant d'une séquence d'impulsions RF et de gradient provoquant une atténuation des signaux à partir de la diffusion mais non du flux (données compensées en flux) ; acquérir au moins deux images RM présentant des pondérations de mouvement différentes, provenant d'une séquence d'impulsions RF et de gradient provoquant une atténuation du signal à partir de la diffusion et du flux (données non compensées) ; appliquer un ajustement de modèle aux données compensées en flux et aux données non compensées, dans lequel au moins un des paramètres ajustables et obligatoirement le même pour les deux ensembles de données ; et obtenir des informations quantitatives sur le flux microscopique en extrayant de l'ajustement de modèle au moins un paramètre de l'effet des mouvements incohérents dans le même voxel (IVIM). Le procédé est destiné à l'imagerie de diffusion-perfusion.
CA2876852A 2012-06-29 2013-06-24 Quantification de la quantite relative d'eau dans le reseau microcapillaire d'un tissu Expired - Fee Related CA2876852C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261665998P 2012-06-29 2012-06-29
US61/665,998 2012-06-29
SE1250736-4 2012-06-29
SE1250736 2012-06-29
PCT/SE2013/050755 WO2014003643A1 (fr) 2012-06-29 2013-06-24 Quantification de la quantité relative d'eau dans le réseau microcapillaire d'un tissu

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CA2876852A1 true CA2876852A1 (fr) 2014-01-03
CA2876852C CA2876852C (fr) 2020-12-22

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US (2) US10031204B2 (fr)
EP (1) EP2867690B1 (fr)
JP (1) JP6328624B2 (fr)
KR (1) KR102059408B1 (fr)
CN (1) CN104471423B (fr)
AU (1) AU2013281266B2 (fr)
BR (1) BR112014032534B8 (fr)
CA (1) CA2876852C (fr)
IN (1) IN2014MN02502A (fr)
WO (1) WO2014003643A1 (fr)

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US11241163B2 (en) * 2017-06-08 2022-02-08 The Board Of Trustees Of The University Of Illinois Measuring blood vessel characteristics with MRI
US10684340B1 (en) * 2019-01-08 2020-06-16 Siemens Healthcare Gmbh Systems and methods for predicting errors and optimizing protocols in quantitative magnetic resonance imaging
CN109820506B (zh) * 2019-02-20 2023-07-07 王毅翔 基于磁共振弥散成像的组织血管密度指标检测方法及装置
US11789106B2 (en) * 2020-03-28 2023-10-17 Kalmia Ab Magnetic resonance method, software product, and system for determining a diffusion propagator or related diffusion parameters for spin-labelled particles
CN111407278B (zh) * 2020-03-31 2020-12-29 浙江大学 利用流速补偿和非补偿的弥散磁共振测量胎盘血流的方法及装置
CN115421086B (zh) * 2022-09-02 2023-04-14 哈尔滨医科大学 活体心脏复杂组织学特征精准解析的超融合体素内不相干运动张量磁共振成像方法
CN115877297A (zh) * 2022-12-19 2023-03-31 武汉中科医疗科技工业技术研究院有限公司 磁共振信号衰减原因判别方法、装置及磁共振系统
CN117310581B (zh) * 2023-10-11 2024-05-10 安徽峻德医疗科技有限公司 一种核磁共振信号衰减拟合方法、系统、设备及存储介质

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Also Published As

Publication number Publication date
CA2876852C (fr) 2020-12-22
US10788558B2 (en) 2020-09-29
EP2867690B1 (fr) 2021-11-24
JP6328624B2 (ja) 2018-05-23
US10031204B2 (en) 2018-07-24
US20180224514A1 (en) 2018-08-09
AU2013281266A1 (en) 2015-01-22
CN104471423B (zh) 2017-03-29
BR112014032534B1 (pt) 2021-10-13
BR112014032534B8 (pt) 2023-02-14
WO2014003643A1 (fr) 2014-01-03
BR112014032534A2 (pt) 2017-06-27
IN2014MN02502A (fr) 2015-07-17
AU2013281266B2 (en) 2017-04-13
KR102059408B1 (ko) 2020-02-11
US20150168527A1 (en) 2015-06-18
EP2867690A4 (fr) 2017-01-25
EP2867690A1 (fr) 2015-05-06
JP2015521891A (ja) 2015-08-03
KR20150036296A (ko) 2015-04-07
CN104471423A (zh) 2015-03-25

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