CA2886478A1 - Particules derivees d'acide propionique compressibles directement - Google Patents

Particules derivees d'acide propionique compressibles directement Download PDF

Info

Publication number: CA2886478A1
Authority: CA; Canada
Prior art keywords: propionic acid; acid derivative; ibuprofen; wax; particles
Prior art date: 2014-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2886478A

Other languages

English (en)

Inventor

Saumitra Bagchi

Murali K. VUPPALA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

McNeil PPC Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-28

Filing date

2015-03-27

Publication date

2015-09-28

2014-03-28 Priority claimed from US14/228,957 external-priority patent/US20140213653A1/en

2015-03-27 Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc

2015-09-28 Publication of CA2886478A1 publication Critical patent/CA2886478A1/fr

Status Abandoned legal-status Critical Current

Links

239000002245 particle Substances 0.000 title claims abstract description 74
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title description 5
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239000007891 compressed tablet Substances 0.000 claims abstract description 15
238000004519 manufacturing process Methods 0.000 claims abstract description 15
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 86
229960001680 ibuprofen Drugs 0.000 claims description 82
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical group CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims description 32
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239000000203 mixture Substances 0.000 claims description 29
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MITFXPHMIHQXPI-UHFFFAOYSA-N Oraflex Chemical compound N=1C2=CC(C(C(O)=O)C)=CC=C2OC=1C1=CC=C(Cl)C=C1 MITFXPHMIHQXPI-UHFFFAOYSA-N 0.000 claims description 4
DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 4
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RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 claims description 2
RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 claims description 2
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239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

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Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

CA2886478A 2014-03-28 2015-03-27 Particules derivees d'acide propionique compressibles directement Abandoned CA2886478A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14/228,957 US20140213653A1 (en)	2012-09-18	2014-03-28	Directly compressible proprionic acid derivative particles
US14/228,957		2014-03-28

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Publication Number	Publication Date
CA2886478A1 true CA2886478A1 (fr)	2015-09-28

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CA2886478A Abandoned CA2886478A1 (fr)	2014-03-28	2015-03-27	Particules derivees d'acide propionique compressibles directement

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CN (1)	CN105168155A (fr)
AU (1)	AU2015201584A1 (fr)
BR (1)	BR102015007013A2 (fr)
CA (1)	CA2886478A1 (fr)
RU (1)	RU2015110511A (fr)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5405617A (en) *	1991-11-07	1995-04-11	Mcneil-Ppc, Inc.	Aliphatic or fatty acid esters as a solventless carrier for pharmaceuticals
US20030232097A1 (en) *	2002-06-17	2003-12-18	Strides Inc.	Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen
US7423004B2 (en) *	2003-01-31	2008-09-09	Smithkline Beecham Corporation	Solid dispersion compositions
CA2884119A1 (fr) *	2012-09-18	2014-03-27	Mcneil-Ppc, Inc.	Particules de derives d'acide propionique a point de fusion bas, destinees a etre utilisees dans des formes galeniques orales

2015
- 2015-03-24 RU RU2015110511A patent/RU2015110511A/ru not_active Application Discontinuation
- 2015-03-27 AU AU2015201584A patent/AU2015201584A1/en not_active Abandoned
- 2015-03-27 CN CN201510140784.2A patent/CN105168155A/zh active Pending
- 2015-03-27 CA CA2886478A patent/CA2886478A1/fr not_active Abandoned
- 2015-03-30 BR BR102015007013A patent/BR102015007013A2/pt not_active Application Discontinuation

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BR102015007013A2 (pt)	2015-12-15
AU2015201584A1 (en)	2015-10-15
RU2015110511A (ru)	2016-10-20

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JP5452236B2 (ja)	2014-03-26	ロウ様物質を用いた徐放性組成物
RU2222323C2 (ru)	2004-01-27	Композиция для орального введения, способ снижения обжигающего послевкусия композиций пропионовой кислоты
US20110135723A1 (en)	2011-06-09	Pharmaceutical compositions containing pregabalin
MX2011007399A (es)	2011-11-18	Suspension farmaceutica de liberacion doble.
AU2009289464A1 (en)	2010-03-11	Chewable sustained release formulations
CA2456604C (fr)	2011-02-08	Composition pharmaceutique comprenant du lumiracoxib
WO2009084041A2 (fr)	2009-07-09	Compositions pharmaceutiques de dexibuprofène
AU2013318356A1 (en)	2015-03-19	Low melting propionic acid derivative particles for use in oral dosage forms
US20140213653A1 (en)	2014-07-31	Directly compressible proprionic acid derivative particles
JP2007055924A (ja)	2007-03-08	イブプロフェン及び塩酸アンブロキソール含有固形製剤
AU2018202909A1 (en)	2018-05-17	Sustained release oral dosage forms comprising low melting propionic acid derivative particles
KR101680925B1 (ko)	2016-11-29	불쾌미 마스킹 입자 및 이것을 함유하는 경구제제
CA2886478A1 (fr)	2015-09-28	Particules derivees d'acide propionique compressibles directement
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US20140256810A1 (en)	2014-09-11	Low melting propionic acid derivative particles for use in oral dosage forms
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WO2019030773A1 (fr)	2019-02-14	Compositions de diclofénac à faible dose
GB2340038A (en)	2000-02-16	NSAID composition