CA2904140C - Procedes de traitement d'affections pancreatiques et hepatiques par transplantation de cellules souches dans les parois de canaux biliaires - Google Patents

Procedes de traitement d'affections pancreatiques et hepatiques par transplantation de cellules souches dans les parois de canaux biliaires Download PDF

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Publication number
CA2904140C
CA2904140C CA2904140A CA2904140A CA2904140C CA 2904140 C CA2904140 C CA 2904140C CA 2904140 A CA2904140 A CA 2904140A CA 2904140 A CA2904140 A CA 2904140A CA 2904140 C CA2904140 C CA 2904140C
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Prior art keywords
cells
use according
pancreatic
suspension
stem
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CA2904140A
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English (en)
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CA2904140A1 (fr
Inventor
Lola Mcadams Reid
Yunfang Wang
David A. Gerber
Giacomo LANZONI
Luca Inverardi
Juan Dominguez-Bendala
Domenico Alvaro
Vincenzo Cardinale
Eugenio Gaudio
Guido Carpino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Roma La Sapienza
University of North Carolina at Chapel Hill
University of Miami
Original Assignee
Universita degli Studi di Roma La Sapienza
University of North Carolina at Chapel Hill
University of Miami
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Publication of CA2904140A1 publication Critical patent/CA2904140A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Neurology (AREA)

Abstract

La présente invention concerne un procédé de réparation d'un pancréas ou d'un foie malade ou dysfonctionnel. Le procédé met en uvre la préparation d'une suspension de cellules souches et/ou cellules progénitrices telles que des cellules souches d'arbre biliaire, des cellules souches hépatiques, des cellules souches pancréatiques ou leurs descendants, des cellules progénitrices compétentes, de tissu sain du patient ou de l'arbre biliaire d'un donneur non autologue et le greffage des cellules dans la paroi de canaux biliaires à proximité de l'organe à traiter. La greffe est constituée de cellules souches ou progénitrices qui sont mélangées avec des biomatériaux et, facultativement, avec des cytokines et/ou des cellules épithéliales-mésenchymateuses natives appropriées pour le stade de lignage de maturation des cellules à greffer. Les cellules sont spécifiquement introduites dans le canal commun hépato-pancréatique du sujet pour le traitement d'affections pancréatiques ou dans la paroi du canal biliaire à proximité du foie pour le traitement d'affections hépatiques et laissées à migrer vers le pancréas ou vers le foie et se développer et ensuite reconstruire une partie ou l'intégralité de l'organe malade ou dysfonctionnel.
CA2904140A 2013-03-13 2014-03-13 Procedes de traitement d'affections pancreatiques et hepatiques par transplantation de cellules souches dans les parois de canaux biliaires Active CA2904140C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361780644P 2013-03-13 2013-03-13
US61/780,644 2013-03-13
US14/207,191 2014-03-12
US14/207,191 US9533013B2 (en) 2013-03-13 2014-03-12 Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
PCT/US2014/026461 WO2014143632A1 (fr) 2013-03-13 2014-03-13 Procédés de traitement d'affections pancréatiques et hépatiques par transplantation de cellules souches dans les parois de canaux biliaires

Publications (2)

Publication Number Publication Date
CA2904140A1 CA2904140A1 (fr) 2014-09-18
CA2904140C true CA2904140C (fr) 2023-10-17

Family

ID=51537508

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2904140A Active CA2904140C (fr) 2013-03-13 2014-03-13 Procedes de traitement d'affections pancreatiques et hepatiques par transplantation de cellules souches dans les parois de canaux biliaires

Country Status (18)

Country Link
US (2) US9533013B2 (fr)
EP (2) EP3733219B1 (fr)
JP (1) JP2016513466A (fr)
KR (1) KR20150130434A (fr)
CN (1) CN105264065A (fr)
AU (1) AU2014228310A1 (fr)
BR (1) BR112015021453A8 (fr)
CA (1) CA2904140C (fr)
CL (1) CL2015002557A1 (fr)
CR (1) CR20150543A (fr)
ES (2) ES2968686T3 (fr)
HK (1) HK1218430A1 (fr)
IL (1) IL240934A0 (fr)
MX (1) MX2015012120A (fr)
PH (1) PH12015502034A1 (fr)
RU (2) RU2015143617A (fr)
SG (2) SG10201707522RA (fr)
WO (1) WO2014143632A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491931B (zh) * 2014-12-02 2017-04-12 清华大学深圳研究生院 含有皮脂腺的皮肤组织及其形成方法和用途
WO2016161192A1 (fr) 2015-04-03 2016-10-06 Propagenix Inc. Prolifération ex vivo de cellules épithéliales
WO2017044454A1 (fr) * 2015-09-11 2017-03-16 Propagenix Inc. Prolifération ex vivo de cellules épithéliales
EP3541923A4 (fr) * 2016-11-15 2020-06-17 Regrow Biosciences Pvt. Ltd. Procédé de préparation d'une suspension de cellules épithéliales buccales et son utilisation
EP3600350A4 (fr) * 2017-03-25 2021-01-27 University of Miami Échafaudage biologique comprenant des cellules thérapeutiques
CN111032090A (zh) * 2017-06-12 2020-04-17 北卡罗来纳大学教堂山分校 用于细胞植入的补片植入物组合物
GB201709704D0 (en) 2017-06-19 2017-08-02 Cambridge Entpr Ltd Methods of expanding cholangiocytes
CN112272698A (zh) * 2018-03-29 2021-01-26 北卡罗来纳大学教堂山分校 来自十二指肠布鲁纳氏腺的干/祖细胞及其分离和使用方法
IL324627A (en) * 2019-04-11 2026-01-01 Univ Pittsburgh Commonwealth Sys Higher Education A minimally invasive cell transplantation procedure to induce the development of organ formation in an animal body.
GB202102235D0 (en) * 2021-02-17 2021-03-31 Cambridge Entpr Ltd Cell transplantation
WO2025117683A1 (fr) * 2023-11-29 2025-06-05 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions et procédés de pancréatectomie chimique pour transplantation de pancréas

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
JP2002171865A (ja) * 2000-12-05 2002-06-18 Kansai Tlo Kk 内臓疾患実験動物モデル、その作製方法及びそれを用いた薬物の評価方法
US20020155096A1 (en) * 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US6805860B1 (en) * 2001-09-30 2004-10-19 Eckhard Alt Method of transluminal application of myogenic cells for repair or replacement of heart tissue
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
CA2553303C (fr) * 2004-01-14 2014-06-10 Novahep Ab Cellules progenitrices hepatiques humaines et procedes d'utilisation correspondants
AU2006315163A1 (en) 2005-11-16 2007-05-24 University Of North Carolina At Chapel Hill Extracellular matrix components for expansion or differentiation of hepatic progenitors
EP2019859A4 (fr) * 2006-04-25 2009-11-25 Univ Louisiana State Cellules souches adultes adipeuses dérivées utilisées dans la regénération hépatique
ES2664375T3 (es) 2006-05-26 2018-04-19 The University Of North Carolina At Chapel Hill Precursores de células estrelladas hepáticas y métodos para aislarlos
WO2008101215A1 (fr) * 2007-02-16 2008-08-21 Varian Medical Systems Technologies, Inc. Schéma préparatoire pour prise de greffe, croissance et différentiation de cellules non hématopoïétiques in vivo
WO2008109659A2 (fr) 2007-03-06 2008-09-12 University Of North Carolina At Chapel Hill Complexe d'hyaluronanes, autres composants de matrice, hormones et facteurs de croissance pour maintenance, expansion et/ou différenciation de cellules
CA2727535A1 (fr) 2007-06-15 2008-12-24 University Of North Carolina At Chapel Hill Signaux paracrines provenant de cellules nourricieres mesenchymateuses et regulation de l'expansion et de la differenciation de cellules souches utilisant ces signaux
US9125891B2 (en) * 2008-03-07 2015-09-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Lymph nodes as a site for regeneration
US20120189702A1 (en) * 2009-08-06 2012-07-26 Albert Einstein College Of Medicine Of Yeshiva University Cell therapy for treatment of liver failure
EP2471542B1 (fr) * 2009-08-28 2016-04-27 Osaka Air Machine Service, Ltd. Agent thérapeutique pour maladies hépatiques
CN105456292B (zh) 2009-10-30 2019-03-26 北卡罗来纳大学教堂山分校 来自肝外胆管树的专能干细胞及其分离方法
EP2506913B8 (fr) * 2009-12-02 2020-11-18 RenovoRX, Inc. Dispositifs et ensembles de délivrance de produits thérapeutiques à un pancréas
AU2011247984B2 (en) 2010-05-07 2015-04-30 University Of North Carolina At Chapel Hill Method of engrafting cells from solid tissues
PL2588027T3 (pl) 2010-07-02 2017-09-29 The University Of North Carolina At Chapel Hill Rusztowania biomacierzowe do rozpraszania na skalę przemysłową
US20150265656A1 (en) * 2012-10-12 2015-09-24 The Johns Hopkins University Human endocrine progenitors from adult pancreatic tissue

Also Published As

Publication number Publication date
CR20150543A (es) 2016-02-24
AU2014228310A1 (en) 2015-10-08
JP2016513466A (ja) 2016-05-16
US20140301985A1 (en) 2014-10-09
CA2904140A1 (fr) 2014-09-18
US20160058798A1 (en) 2016-03-03
BR112015021453A2 (pt) 2017-07-18
US9750770B2 (en) 2017-09-05
US9533013B2 (en) 2017-01-03
SG10201707522RA (en) 2017-10-30
EP3733219A1 (fr) 2020-11-04
ES2968686T3 (es) 2024-05-13
EP3733219B1 (fr) 2023-11-01
PH12015502034A1 (en) 2016-01-18
RU2015143617A3 (fr) 2018-03-22
RU2015143617A (ru) 2017-04-20
SG11201507285WA (en) 2015-10-29
BR112015021453A8 (pt) 2021-07-06
EP2970879A1 (fr) 2016-01-20
EP2970879A4 (fr) 2016-12-28
CN105264065A (zh) 2016-01-20
RU2018122958A (ru) 2019-03-06
EP2970879B1 (fr) 2020-11-04
ES2848075T3 (es) 2021-08-05
IL240934A0 (en) 2015-11-30
KR20150130434A (ko) 2015-11-23
WO2014143632A1 (fr) 2014-09-18
CL2015002557A1 (es) 2016-08-26
MX2015012120A (es) 2016-05-18
HK1218430A1 (zh) 2017-02-17

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