CA2906685A1 - Methods and materials for providing teeth with a white appearance - Google Patents

Methods and materials for providing teeth with a white appearance Download PDF

Info

Publication number: CA2906685A1
Authority: CA; Canada
Prior art keywords: polypeptide; teeth; composition; adhesive; particle
Prior art date: 2013-03-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2906685A

Other languages

English (en)

French (fr)

Inventor

Richard Simon Brody

Thomas Joel Zupancic

Nicole Hoefer

Uday B. Sandbhor

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SAFEWHITE Inc

Original Assignee

SAFEWHITE Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-14

Filing date

2014-03-14

Publication date

2014-09-25

2014-03-14 Application filed by SAFEWHITE Inc filed Critical SAFEWHITE Inc

2014-09-25 Publication of CA2906685A1 publication Critical patent/CA2906685A1/en

Status Abandoned legal-status Critical Current

Links

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Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Cosmetics (AREA)
Dental Preparations (AREA)
Peptides Or Proteins (AREA)
Luminescent Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

CA2906685A 2013-03-14 2014-03-14 Methods and materials for providing teeth with a white appearance Abandoned CA2906685A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201361785966P	2013-03-14	2013-03-14
US61/785,966		2013-03-14
US201361903671P	2013-11-13	2013-11-13
US61/903,671		2013-11-13
PCT/US2014/028233 WO2014152918A1 (en)	2013-03-14	2014-03-14	Methods and materials for providing teeth with a white appearance

Publications (1)

Publication Number	Publication Date
CA2906685A1 true CA2906685A1 (en)	2014-09-25

Family

ID=51581354

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2906685A Abandoned CA2906685A1 (en)	2013-03-14	2014-03-14	Methods and materials for providing teeth with a white appearance

Country Status (7)

Country	Link
US (1)	US20160030323A1 (2)
EP (1)	EP2969023A4 (2)
JP (1)	JP2016519077A (2)
AU (1)	AU2014236492A1 (2)
BR (1)	BR112015022442A2 (2)
CA (1)	CA2906685A1 (2)
WO (1)	WO2014152918A1 (2)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX354968B (es)	2013-12-20	2018-03-27	Colgate Palmolive Co	Producto para el cuidado oral con blanqueador dental con particulas de silice de nucleo cubierto.
MX367806B (es)	2013-12-20	2019-09-06	Colgate Palmolive Co	Partículas de sílice de núcleo-cubierta y uso para reducción del mal olor.
CN108700507B (zh)	2015-12-18	2022-05-27	拜奥法尔防护有限责任公司	固体荧光标准品
MX388207B (es) *	2016-12-21	2025-03-19	Colgate Palmolive Co	Composiciones dentífricas blanqueadoras con partículas de sílice de núcleo-cubierta de zinc.
US10667994B2 (en) *	2018-03-09	2020-06-02	The Regents Of The University Of California	Bioactive dental restorative material with remineralization properties
CN114599311B (zh) *	2019-10-22	2025-02-21	皇家飞利浦有限公司	牙齿美白系统
JPWO2023058512A1 (2) *	2021-10-07	2023-04-13

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6323670A (ja) *	1986-04-25	1988-01-30	バイオ−ポリマ−ズ　インコ−ポレ−テツド	接着・被覆組成物とその使用方法
US7858679B2 (en) *	2001-07-20	2010-12-28	Northwestern University	Polymeric compositions and related methods of use
US7947806B2 (en) *	2005-04-08	2011-05-24	Postech Foundation	Mussel bioadhesive
US9072672B2 (en) *	2005-06-28	2015-07-07	Colgate-Palmolive Company	Compositions and methods for altering the color of teeth
EP1808187A1 (en) *	2006-01-11	2007-07-18	Straumann Holding AG	Cell selective implant surface with controlled release of bioactive agents
US7622533B2 (en) *	2006-08-04	2009-11-24	Nerites Corporation	Biomimetic compounds and synthetic methods therefor
WO2011025158A2 (ko) *	2009-08-25	2011-03-03	포항공과대학교 산학협력단	홍합 접착 단백질 또는 이의 변이체에 음이온성 고분자가 포함된 코아세르베이트
US8765168B2 (en) *	2009-11-06	2014-07-01	The Regents Of The University Of Michigan	Compositions of a fluorapatite and methods of use
AU2011293349B2 (en) *	2010-08-24	2014-04-03	Safewhite, Inc.	Methods and materials for providing teeth with a white appearance
US20120202748A1 (en) *	2011-02-07	2012-08-09	Postech Academy-Industry Foundation	Recombinant mussel adhesive protein fp-131

2014
- 2014-03-14 CA CA2906685A patent/CA2906685A1/en not_active Abandoned
- 2014-03-14 EP EP14768008.6A patent/EP2969023A4/en not_active Withdrawn
- 2014-03-14 US US14/776,524 patent/US20160030323A1/en not_active Abandoned
- 2014-03-14 BR BR112015022442A patent/BR112015022442A2/pt not_active IP Right Cessation
- 2014-03-14 AU AU2014236492A patent/AU2014236492A1/en not_active Abandoned
- 2014-03-14 JP JP2016502742A patent/JP2016519077A/ja not_active Withdrawn
- 2014-03-14 WO PCT/US2014/028233 patent/WO2014152918A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO2014152918A1 (en)	2014-09-25
BR112015022442A2 (pt)	2017-10-24
AU2014236492A1 (en)	2015-10-01
EP2969023A4 (en)	2016-08-24
JP2016519077A (ja)	2016-06-30
EP2969023A1 (en)	2016-01-20
US20160030323A1 (en)	2016-02-04

Legal Events

Date	Code	Title	Description
2017-09-05	FZDE	Discontinued	Effective date: 20170718

Publication	Publication Date	Title
US20160030323A1 (en)	2016-02-04	Methods and materials for providing teeth with a white appearance
US8784783B2 (en)	2014-07-22	Methods and materials for providing teeth with a white appearance
JP6649251B2 (ja)	2020-02-19	歯を白くするためのデンタルケア製品
US20170296450A1 (en)	2017-10-19	Methods and materials for delivering agents to hair, skin, or nails
US12569417B2 (en)	2026-03-10	Compositions and methods for promoting mineralization
US20140271500A1 (en)	2014-09-18	Methods and materials for providing teeth with a white appearance
US20200368136A1 (en)	2020-11-26	Polyelectrolyte dental adhesives for whitening teeth and teeth components
JP2022548797A (ja)	2022-11-21	第一スズイオン源、中性アミノ酸、及びポリホスフェートを含む口腔ケア組成物
Xu	2015	New approaches to tooth whitening based on changing the optical properties with calcium phosphate containing suspensions
EA048783B1 (ru)	2025-01-14	Композиция и способ для стимулирования минерализации