CA2913490C - Compositions et procedes d'identification, d'evaluation, de prevention et de traitement du cancer en utilisant des isoformes pd-l1 - Google Patents

Compositions et procedes d'identification, d'evaluation, de prevention et de traitement du cancer en utilisant des isoformes pd-l1

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Publication number
CA2913490C
CA2913490C CA2913490A CA2913490A CA2913490C CA 2913490 C CA2913490 C CA 2913490C CA 2913490 A CA2913490 A CA 2913490A CA 2913490 A CA2913490 A CA 2913490A CA 2913490 C CA2913490 C CA 2913490C
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Canada
Prior art keywords
level
biomarkers
expression
acid sequence
amino acid
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CA2913490A
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English (en)
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CA2913490A1 (fr
Inventor
Peter Hammerman
Matthew Meyerson
Chandra Pedamallu
Sam Freeman
Original Assignee
Dana Farber Cancer Institute Inc
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Priority claimed from PCT/US2014/040504 external-priority patent/WO2014197369A1/fr
Publication of CA2913490A1 publication Critical patent/CA2913490A1/fr
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Publication of CA2913490C publication Critical patent/CA2913490C/fr
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Abstract

La présente invention concerne des procédés d'identification, d'évaluation, de prévention et de traitement du cancer (<i />par exemple, les cancers de la tête, du cou et/ou du poumon chez les humains). Une variété de biomarqueurs d'isoforme PD-L1 sont fournis, les modifications du nombre de copies d'au moins un des biomarqueurs et/ou les modifications de la quantité, de la structure et/ou de l'activité d'un ou de plusieurs des biomarqueurs étant associées au statut du cancer et indiquant la possibilité de traitement et de prévention par modulation des niveaux de PD-1 et/ou de PD-L1.
CA2913490A 2013-06-06 2014-06-02 Compositions et procedes d'identification, d'evaluation, de prevention et de traitement du cancer en utilisant des isoformes pd-l1 Active CA2913490C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361831894P 2013-06-06 2013-06-06
US61/831,894 2013-06-06
PCT/US2014/040504 WO2014197369A1 (fr) 2013-06-06 2014-06-02 Compositions et procédés d'identification, d'évaluation, de prévention et de traitement du cancer en utilisant des isoformes pd-l1

Publications (2)

Publication Number Publication Date
CA2913490A1 CA2913490A1 (fr) 2014-12-11
CA2913490C true CA2913490C (fr) 2025-07-22

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