CA2920016C - Proteines d'hemagglutinine de la grippe et methodes d'utilisation associees - Google Patents

Proteines d'hemagglutinine de la grippe et methodes d'utilisation associees

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Publication number
CA2920016C
CA2920016C CA2920016A CA2920016A CA2920016C CA 2920016 C CA2920016 C CA 2920016C CA 2920016 A CA2920016 A CA 2920016A CA 2920016 A CA2920016 A CA 2920016A CA 2920016 C CA2920016 C CA 2920016C
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CA
Canada
Prior art keywords
influenza
amino acid
seq
protein
tyrosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2920016A
Other languages
English (en)
Other versions
CA2920016A1 (fr
Inventor
Christopher Patrick Marshall
Peter Joseph Alff
Claudio Bertuccioli
Mark Andrew Yondola
Original Assignee
Calder Biosciences Inc
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Publication date
Application filed by Calder Biosciences Inc filed Critical Calder Biosciences Inc
Priority claimed from PCT/US2014/049509 external-priority patent/WO2015020913A2/fr
Publication of CA2920016A1 publication Critical patent/CA2920016A1/fr
Application granted granted Critical
Publication of CA2920016C publication Critical patent/CA2920016C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne, selon certains modes de réalisation, des polypeptides, des protéines et des complexes de protéines d'hémagglutinine (« HA ») de la grippe qui comprennent un domaine queue qui est génétiquement modifié en vue de faciliter la maintenance de sa conformation trimérique native, y compris si le domaine tête de la protéine HA est retiré ou fait l'objet d'une disruption. Selon certains modes de réalisation, la présente invention concerne des compositions comprenant de tels polypeptides, protéines et complexes de protéines, et des méthodes d'utilisation de telles protéines et compositions, par exemple en tant qu'immunogènes de vaccin.
CA2920016A 2013-08-03 2014-08-02 Proteines d'hemagglutinine de la grippe et methodes d'utilisation associees Active CA2920016C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361861989P 2013-08-03 2013-08-03
US61/861,989 2013-08-03
PCT/US2014/049509 WO2015020913A2 (fr) 2013-08-03 2014-08-02 Protéines d'hémagglutinine de la grippe et méthodes associées

Publications (2)

Publication Number Publication Date
CA2920016A1 CA2920016A1 (fr) 2015-02-12
CA2920016C true CA2920016C (fr) 2026-01-13

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