CA2922013C - Inducteurs chimiques d'hemoglobine foetale - Google Patents

Inducteurs chimiques d'hemoglobine foetale Download PDF

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Publication number
CA2922013C
CA2922013C CA2922013A CA2922013A CA2922013C CA 2922013 C CA2922013 C CA 2922013C CA 2922013 A CA2922013 A CA 2922013A CA 2922013 A CA2922013 A CA 2922013A CA 2922013 C CA2922013 C CA 2922013C
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CA
Canada
Prior art keywords
hbf
thalassemia
blood
beta
globin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2922013A
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English (en)
Other versions
CA2922013A1 (fr
Inventor
Susan P. Perrine
Douglas V. Faller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phoenicia Biosciences Inc
Original Assignee
Phoenicia Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phoenicia Biosciences Inc filed Critical Phoenicia Biosciences Inc
Priority to CA3120111A priority Critical patent/CA3120111A1/fr
Publication of CA2922013A1 publication Critical patent/CA2922013A1/fr
Application granted granted Critical
Publication of CA2922013C publication Critical patent/CA2922013C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de manière générale des compositions contenant des composés chimiques et des compositions et des formulations pharmaceutiques des composés qui augmentent l'hémoglobine totale ou la protéine globine, telle que la globine embryonnaire ou ftale, ou la prolifération de cellules exprimant l'hémoglobine. Des composés préférés comprennent le bensérazide, un inhibiteur de l'histone désacétylase à base de benzamide, tel que l'entinostat ou un ou plusieurs parmi l'ambroxol, la desloratadine, le resvératrol ou le NSC-95397. Ces compositions peuvent être utilisées pour traiter ou prévenir les symptômes associés à des drépanocytoses, des thalassémies bêta et d'autres déficiences des cellules sanguines et troubles sanguins. L'invention concerne également des procédés d'administration de ces compositions à des sujets et d'utilisation comme aide médicale pour le traitement et la prévention d'anémies provoquées par des mutations du gène de la globine et d'autres troubles de des globules rouges.
CA2922013A 2013-08-20 2014-08-20 Inducteurs chimiques d'hemoglobine foetale Active CA2922013C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3120111A CA3120111A1 (fr) 2013-08-20 2014-08-20 Inducteurs chimiques d'hemoglobine foetale

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361867965P 2013-08-20 2013-08-20
US61/867,965 2013-08-20
PCT/US2014/051887 WO2015026939A1 (fr) 2013-08-20 2014-08-20 Inducteurs chimiques d'hémoglobine foetale

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3120111A Division CA3120111A1 (fr) 2013-08-20 2014-08-20 Inducteurs chimiques d'hemoglobine foetale

Publications (2)

Publication Number Publication Date
CA2922013A1 CA2922013A1 (fr) 2015-02-26
CA2922013C true CA2922013C (fr) 2021-06-08

Family

ID=52484128

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3120111A Pending CA3120111A1 (fr) 2013-08-20 2014-08-20 Inducteurs chimiques d'hemoglobine foetale
CA2922013A Active CA2922013C (fr) 2013-08-20 2014-08-20 Inducteurs chimiques d'hemoglobine foetale

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3120111A Pending CA3120111A1 (fr) 2013-08-20 2014-08-20 Inducteurs chimiques d'hemoglobine foetale

Country Status (2)

Country Link
CA (2) CA3120111A1 (fr)
WO (1) WO2015026939A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080075692A1 (en) * 2006-05-09 2008-03-27 Perrine Susan P Methods for treating blood disorders
US20110015168A1 (en) * 2007-01-19 2011-01-20 Mitchell Keegan Methods for increasing levels of human fetal hemoglobin

Also Published As

Publication number Publication date
WO2015026939A1 (fr) 2015-02-26
CA3120111A1 (fr) 2015-02-26
CA2922013A1 (fr) 2015-02-26

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