CA2939916A1 - Compositions and methods for pain relief without numbness - Google Patents

Compositions and methods for pain relief without numbness Download PDF

Info

Publication number
CA2939916A1
CA2939916A1 CA2939916A CA2939916A CA2939916A1 CA 2939916 A1 CA2939916 A1 CA 2939916A1 CA 2939916 A CA2939916 A CA 2939916A CA 2939916 A CA2939916 A CA 2939916A CA 2939916 A1 CA2939916 A1 CA 2939916A1
Authority
CA
Canada
Prior art keywords
surgery
composition
anesthetic
local
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2939916A
Other languages
English (en)
French (fr)
Inventor
Glenn Abrahmsohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2939916A1 publication Critical patent/CA2939916A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2939916A 2014-02-18 2015-02-18 Compositions and methods for pain relief without numbness Abandoned CA2939916A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461941307P 2014-02-18 2014-02-18
US61/941,307 2014-02-18
PCT/US2015/016379 WO2015126942A1 (en) 2014-02-18 2015-02-18 Compositions and methods for pain relief without numbness

Publications (1)

Publication Number Publication Date
CA2939916A1 true CA2939916A1 (en) 2015-08-27

Family

ID=53878913

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2939916A Abandoned CA2939916A1 (en) 2014-02-18 2015-02-18 Compositions and methods for pain relief without numbness

Country Status (7)

Country Link
US (1) US20170224726A1 (2)
EP (1) EP3107551B1 (2)
JP (2) JP2017508004A (2)
CA (1) CA2939916A1 (2)
ES (1) ES2841143T3 (2)
PL (1) PL3107551T3 (2)
WO (1) WO2015126942A1 (2)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117847B2 (en) * 2015-12-04 2018-11-06 Ventis Pharma Extended duration local anesthetic formulation
RU2651709C2 (ru) * 2016-09-20 2018-04-23 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПбГПМУ Минздрава России) Способ обезболивания при биопсии кожи
RU2629204C1 (ru) * 2016-09-29 2017-08-25 Общество С Ограниченной Ответственностью "Научно-Технологическая Фармацевтическая Фирма "Полисан" Способ получения стабилизированной фармацевтической композиции в виде водного раствора
PL447737A1 (pl) * 2024-02-15 2025-08-18 Janczewski Karol Med Balance Integra - miejscowa kompozycja przeciwbólowa do operacji w bezkrwawym polu operacyjnym.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4213841A (en) * 1978-04-04 1980-07-22 J & M Instruments Corp. pH Measuring instrument kit
US4550022A (en) * 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
US5385738A (en) 1983-10-14 1995-01-31 Sumitomo Pharmaceuticals Company, Ltd. Sustained-release injection
US5209724A (en) 1988-04-11 1993-05-11 Dhaliwal Avtar S Composite anesthetic article and method of use
US5192527A (en) 1991-07-01 1993-03-09 Abrahmsohn Glenn M Method of reversing local anesthesia and reagent system therefor
US6350781B1 (en) 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
NZ311474A (en) 1995-06-09 1997-09-22 Euro Celtique Sa Formulations for providing prolonged local anesthesia
WO1999049849A1 (en) 1998-03-31 1999-10-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal bupivacaine compositions and methods of preparation
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CA2928387A1 (en) 2004-05-03 2005-11-17 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
CN101754766A (zh) * 2007-05-22 2010-06-23 格伦·亚伯拉罕苏恩 疼痛控制的方法
US8828452B2 (en) * 2007-05-22 2014-09-09 Glenn Abrahmsohn Method for pain control
US9198953B2 (en) * 2009-08-14 2015-12-01 Eu Sol Biotech Co., Ltd. Method for repairing neurodegeneration
SG11201505907PA (en) * 2013-02-18 2015-08-28 Glenn Abrahmsohn Compositions and methods for pain relief without numbness

Also Published As

Publication number Publication date
US20170224726A1 (en) 2017-08-10
ES2841143T3 (es) 2021-07-07
JP2017508004A (ja) 2017-03-23
EP3107551B1 (en) 2020-10-28
WO2015126942A1 (en) 2015-08-27
JP2020055840A (ja) 2020-04-09
EP3107551A1 (en) 2016-12-28
EP3107551A4 (en) 2017-10-18
PL3107551T3 (pl) 2021-05-04

Similar Documents

Publication Publication Date Title
US11116789B2 (en) Compositions and methods for pain relief without numbness
JP2010531298A (ja) 疼痛を治療するための局所用組成物
ES2836184T3 (es) Formulaciones tópicas de co-enzima Q10 y tratamiento de heridas
JP2020055840A (ja) 麻痺を伴わない疼痛緩和のための組成物および方法
Ghali et al. Effects of lidocaine and epinephrine on cutaneous blood flow
US8828452B2 (en) Method for pain control
US20080292731A1 (en) Method for pain control
Ghai et al. Addition of midazolam to continuous postoperative epidural bupivacaine infusion reduces requirement for rescue analgesia in children undergoing upper abdominal and flank surgery
HK1219229B (en) Compositions and methods for pain relief without numbness
US20100190860A1 (en) Methods for selectively enhancing antinociceptive potency of local anesthetics
Mohamad et al. Neostigmine and ketorolac as adjuvants to local anesthetic through peribulbar block in patients undergoing vitrectomy surgeries: A randomized controlled trial
Serour et al. Alkalinizing local anesthetic does not decrease pain during injection for dorsal penile nerve block
Akinyemi et al. Evaluation of the perioperative analgesic effects of caudal block for herniotomy in children at the University College Hospital Ibadan, Nigeria.
Lockhart (834): Topical sterile lidocaine patch to reduce postoperative pain and decrease need for oral analgesics after inguinal herniorrhaphy
Reis Jr Intravenous regional anesthesia first century (1908-2008): Beggining, development, and current status
CN104487051B (zh) 用于脊椎施用的可注射过饱和对乙酰氨基酚溶液
UA122476C2 (uk) М'яка лікарська форма для місцевого лікування поверхневих інфантильних гемангіом
Amith et al. A Comparative Study Between Epidural Isobaric Levobupivacaine 0.5% and Isobaric Ropivacaine 0.75% in Lower Abdominal and Lower Limb Surgeries
Locketz et al. (833): Broken heart syndrome following acute withdrawal of opioid therapy in the perioperative setting
Sutters et al. (832): The effectiveness of a scheduled oral analgesic dosing regimen for the management of postoperative pain in preschool children following tonsillectomy
Hatfield et al. (835): The analgesic properties of oral sucrose: Efficacy and duration during routine immunizations at 2 and 4 months of age
BRPI0200827B1 (pt) Association of triancinolone 40mg acetate with 0.5% silver nitrate in the treatment of hemangioms and lymphemangiomas by intralesional infiltration in children

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210831