CA2943328C - Methode de preparation d'immunoglobulines - Google Patents

Methode de preparation d'immunoglobulines Download PDF

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Publication number
CA2943328C
CA2943328C CA2943328A CA2943328A CA2943328C CA 2943328 C CA2943328 C CA 2943328C CA 2943328 A CA2943328 A CA 2943328A CA 2943328 A CA2943328 A CA 2943328A CA 2943328 C CA2943328 C CA 2943328C
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Canada
Prior art keywords
solution
immunoglobulins
concentration
caprylate
peg
Prior art date
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Active
Application number
CA2943328A
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English (en)
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CA2943328A1 (fr
Inventor
Pere Ristol Debart
Salvador Grancha Gamon
Juan Ignacio Jorquera Nieto
Maria Mercedes Faro Tomas
Nuria Jorba Grifols
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Instituto Grifols SA
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Instituto Grifols SA
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Publication date
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Priority to CA2943328A priority Critical patent/CA2943328C/fr
Publication of CA2943328A1 publication Critical patent/CA2943328A1/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne une méthode de préparation dune solution dimmunoglobulines fondée sur une solution initiale dimmunoglobulines dont la pureté est plus grande ou égale à 96 % en présence dun polyéther ou dun polymère de glycol. Elle comprend les étapes suivantes : a) ajouter de lacide caprylique ou des sels connexes à la solution initiale; b) ajuster le pH de la solution obtenue en a); c) incuber la solution obtenue en b) selon une durée et une température nécessaires pour inactiver les virus enveloppés; d) réaliser une étape dultrafiltration/de diafiltration sur la solution obtenue en c).
CA2943328A 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines Active CA2943328C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2943328A CA2943328C (fr) 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2943328A CA2943328C (fr) 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines

Publications (2)

Publication Number Publication Date
CA2943328A1 CA2943328A1 (fr) 2018-03-26
CA2943328C true CA2943328C (fr) 2021-08-03

Family

ID=61759260

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2943328A Active CA2943328C (fr) 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines

Country Status (1)

Country Link
CA (1) CA2943328C (fr)

Also Published As

Publication number Publication date
CA2943328A1 (fr) 2018-03-26

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