CA2950687A1 - Produits de medicament administre par voie nasale et methodes d'utilisation associees - Google Patents

Produits de medicament administre par voie nasale et methodes d'utilisation associees Download PDF

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Publication number
CA2950687A1
CA2950687A1 CA2950687A CA2950687A CA2950687A1 CA 2950687 A1 CA2950687 A1 CA 2950687A1 CA 2950687 A CA2950687 A CA 2950687A CA 2950687 A CA2950687 A CA 2950687A CA 2950687 A1 CA2950687 A1 CA 2950687A1
Authority
CA
Canada
Prior art keywords
patient
naloxone
opioid
formulation
naloxone hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2950687A
Other languages
English (en)
Other versions
CA2950687C (fr
Inventor
Fintan Keegan
Robert Gerard Bell
Roger CRYSTAL
Michael Brenner Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emergent Biosolutions Ireland Ltd
Opiant Pharmaceuticals Inc
Original Assignee
Adapt Pharma Ltd
Opiant Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adapt Pharma Ltd, Opiant Pharmaceuticals Inc filed Critical Adapt Pharma Ltd
Publication of CA2950687A1 publication Critical patent/CA2950687A1/fr
Application granted granted Critical
Publication of CA2950687C publication Critical patent/CA2950687C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2950687A 2015-09-17 2016-09-16 Produits de medicament administre par voie nasale et methodes d'utilisation associees Active CA2950687C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562219955P 2015-09-17 2015-09-17
US62/219,955 2015-09-17
US201662274536P 2016-01-04 2016-01-04
US62/274,536 2016-01-04
PCT/US2016/052280 WO2017049181A1 (fr) 2015-09-17 2016-09-16 Produits médicamenteux d'administration par voie nasale et leurs méthodes d'utilisation

Publications (2)

Publication Number Publication Date
CA2950687A1 true CA2950687A1 (fr) 2017-03-17
CA2950687C CA2950687C (fr) 2023-02-28

Family

ID=58289745

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2950687A Active CA2950687C (fr) 2015-09-17 2016-09-16 Produits de medicament administre par voie nasale et methodes d'utilisation associees

Country Status (4)

Country Link
EP (1) EP3349756A4 (fr)
CA (1) CA2950687C (fr)
MX (1) MX2018003349A (fr)
WO (1) WO2017049181A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180193332A1 (en) * 2017-10-09 2018-07-12 Adapt Pharma Operations Limited Low-temperature stable opioid antagonist solutions
CA3166250A1 (fr) 2020-02-05 2021-08-12 Gregory G. Plucinski Produits medicamenteux destines a etre administres par voie intranasale et utilisations associees

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004054511A2 (fr) * 2002-12-13 2004-07-01 The Regents Of The University Of California Traitement de la douleur avec des combinaisons de nalbuphine et d'autres agonistes de recepteurs kappa-opioides et antagonistes de recepteurs opioides
CN1575795A (zh) * 2003-06-25 2005-02-09 中国人民解放军军事医学科学院毒物药物研究所 盐酸纳洛酮鼻腔喷雾剂
MY194947A (en) * 2011-05-13 2022-12-27 Euro Celtique Sa Intranasal pharmaceutical dosage forms comprising naloxone
CA2875384A1 (fr) * 2013-12-20 2015-06-20 AntiOP, Inc. Compositions de naxlone intranasales et procedes de fabrication et d'utilisation de celles-ci
MX365383B (es) * 2014-03-14 2019-05-31 Opiant Pharmaceuticals Inc Medicamentos de administracion nasal y metodos para su uso.

Also Published As

Publication number Publication date
EP3349756A4 (fr) 2019-05-15
EP3349756A1 (fr) 2018-07-25
WO2017049181A1 (fr) 2017-03-23
MX2018003349A (es) 2018-11-12
CA2950687C (fr) 2023-02-28

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