CA2955441C - Conjugues de dextrane pour cibler les macrophages et d'autres cellules exprimant cd296 - Google Patents

Conjugues de dextrane pour cibler les macrophages et d'autres cellules exprimant cd296 Download PDF

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Publication number
CA2955441C
CA2955441C CA2955441A CA2955441A CA2955441C CA 2955441 C CA2955441 C CA 2955441C CA 2955441 A CA2955441 A CA 2955441A CA 2955441 A CA2955441 A CA 2955441A CA 2955441 C CA2955441 C CA 2955441C
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Canada
Prior art keywords
compound
cancer
disclosed
independently
therapeutic agent
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Active
Application number
CA2955441A
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English (en)
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CA2955441A1 (fr
Inventor
Larry Schlesinger
Eric BACHELDER
Fred COPE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardinal Health 414 LLC
Ohio State Innovation Foundation
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Cardinal Health 414 LLC
Ohio State Innovation Foundation
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Publication of CA2955441A1 publication Critical patent/CA2955441A1/fr
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Publication of CA2955441C publication Critical patent/CA2955441C/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des composés et des compositions pour cibler les macrophages et autres cellules à expression élevée de CD206.
CA2955441A 2014-07-17 2015-07-17 Conjugues de dextrane pour cibler les macrophages et d'autres cellules exprimant cd296 Active CA2955441C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462025991P 2014-07-17 2014-07-17
US62/025,991 2014-07-17
US201462027220P 2014-07-21 2014-07-21
US201462027193P 2014-07-21 2014-07-21
US62/027,193 2014-07-21
US62/027,220 2014-07-21
US201462027733P 2014-07-22 2014-07-22
US62/027,733 2014-07-22
PCT/US2015/041019 WO2016011419A1 (fr) 2014-07-17 2015-07-17 Compositions pour le ciblage de macrophages et autres cellules à expression élevée de cd206 et méthodes de traitement et de diagnostic

Publications (2)

Publication Number Publication Date
CA2955441A1 CA2955441A1 (fr) 2016-01-21
CA2955441C true CA2955441C (fr) 2023-03-14

Family

ID=55079110

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2955441A Active CA2955441C (fr) 2014-07-17 2015-07-17 Conjugues de dextrane pour cibler les macrophages et d'autres cellules exprimant cd296

Country Status (3)

Country Link
EP (1) EP3169336A4 (fr)
CA (1) CA2955441C (fr)
WO (1) WO2016011419A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100196272A1 (en) 2009-01-30 2010-08-05 Neoprobe Corporation Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
CA2955438C (fr) * 2014-07-17 2024-07-02 Ohio State Innovation Foundation Conjugues de dextrane pour cibler les macrophages et d'autres cellules exprimant le recepteur de lectine de type c liant le d-manbose
US10806803B2 (en) 2014-07-17 2020-10-20 Ohio State Innovation Foundation Compositions for targeting macrophages and other CD206 high expressing cells and methods of treating and diagnosis
WO2018067751A1 (fr) * 2016-10-04 2018-04-12 Navidea Biopharmaceuticals, Inc. Compositions et méthodes de diagnostic et de traitement de troubles liés aux macrophages au moyen d'un support macromoléculaire à base de glucides
MX2019004029A (es) 2016-10-07 2019-09-27 Navidea Biopharmaceuticals Inc Compuestos y metodos para diagnosis y tratamiento de infecciones virales.
EP3522899A4 (fr) * 2016-10-07 2020-05-06 Navidea Biopharmaceuticals, Inc. Composés et compositions pour le traitement de la leishmaniose et méthodes de diagnostic et de traitement les utilisant
WO2019018815A1 (fr) * 2017-07-21 2019-01-24 Navidea Biopharmaceuticals, Inc. Utilisation de 99mtc-tilmanocept et de constructions moléculaires associées pour l'identification et le diagnostic de tumeurs malignes, et pour le suivi d'interventions thérapeutiques antitumorales
EP3844500A4 (fr) 2018-08-27 2022-05-11 NantBio, Inc. Compositions de rp182 et procédés
BR112021019187A2 (pt) * 2019-03-27 2021-12-21 Navidea Biopharmaceuticals Inc Método para repolarização de um macrófago associado a tumor de m2 a m1, e, composto para repolarização de um macrófago associado a tumor de m2 a m1
US20210145989A1 (en) * 2019-09-30 2021-05-20 Navidea Biopharmaceuticals, Inc. Compositions and related methods for blocking off-target localization of mannosylated dextrans and other cd206 ligands
EP4076540A4 (fr) 2020-07-08 2024-02-21 Navidea Biopharmaceuticals, Inc. Synthèse de dextranes mannosylés de poids moléculaire définis de manière uniforme et de leurs dérivés
EP4472643A1 (fr) 2022-02-04 2024-12-11 Navidea Biopharmaceuticals, Inc. Modification de la charge nette sur des dextranes mannosylés pour maximiser l'absorption tissulaire cible et le blocage compétitif cible
JP2025517414A (ja) 2022-05-20 2025-06-05 ナビディア、バイオファーマスーティカルズ、インコーポレイテッド 分解性リンカーを介して新規ビスホスホネート薬物ペイロードを担持するｃｄ２０６標的化薬物送達ビヒクル
WO2024076988A2 (fr) 2022-10-03 2024-04-11 Navidea Biopharmaceuticals, Inc. Liaisons amide de fractions de sucre à des liaisons à terminaison amine fixées à des polymères glucidiques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1069820A (en) * 1965-12-21 1967-05-24 Akad Wissenschaften Ddr Tuberculostatic compounds
EP1178838B1 (fr) * 1999-05-14 2004-09-29 The Regents of the University of California Support macromoleculaire sur base de dextran pour l'administration d'un agent diagnostique ou therapeutique
WO2012169973A1 (fr) * 2011-06-09 2012-12-13 Agency For Science, Technology And Research Nanoparticule à cœur-écorce
CA2955438C (fr) * 2014-07-17 2024-07-02 Ohio State Innovation Foundation Conjugues de dextrane pour cibler les macrophages et d'autres cellules exprimant le recepteur de lectine de type c liant le d-manbose

Also Published As

Publication number Publication date
EP3169336A4 (fr) 2018-04-04
WO2016011419A1 (fr) 2016-01-21
CA2955441A1 (fr) 2016-01-21
EP3169336A1 (fr) 2017-05-24

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Effective date: 20200714