CA2963582C - Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal - Google Patents

Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal Download PDF

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Publication number
CA2963582C
CA2963582C CA2963582A CA2963582A CA2963582C CA 2963582 C CA2963582 C CA 2963582C CA 2963582 A CA2963582 A CA 2963582A CA 2963582 A CA2963582 A CA 2963582A CA 2963582 C CA2963582 C CA 2963582C
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CA
Canada
Prior art keywords
polymer
units
methacrylates
polyoxyethylene
methacrylamides
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CA2963582A
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English (en)
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CA2963582A1 (fr
Inventor
Zdenka Sedlakova
Lenka POLAKOVA
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Institute of Macromolecular Chemistry CAS
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Institute of Macromolecular Chemistry CAS
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Publication of CA2963582A1 publication Critical patent/CA2963582A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une préparation pour une utilisation par voie orale pour prévenir et traiter des affections inflammatoires du tractus gastro-intestinal, ladite préparation contenant un polymère hydrophile, biocompatible et muco-adhérent contenant : - au moins un type d'unités structurelles A choisies dans un groupe comportant des unités dérivées d'acides acrylique et méthacrylique et leurs sels, de méthacrylates et d'acrylates d'hydroxyalkyle, de méthacrylamides et d'acrylamides d'hydroxyalkyle, de méthacrylates et d'acrylates de N,N-dialkylaminoalkyle, de méthacrylamides et d'acrylamides de N,N-dialkylaminoalkyle, de N-vinyle-2-pyrrolidone et des mélanges de ceux-ci ; - au moins un type d'unités structurelles B choisies dans un groupe comprenant des unités dérivées de méthacrylates et d'acrylates (polyoxyéthylène) à terminaison hydroxy, de méthacrylates et d'acrylates (polyoxyéthylène) à terminaison alkyloxy, de méthacrylamides et d'acrylamides (polyoxyéthylène) à terminaison hydroxy, de méthacrylamides et d'acrylamides (polyoxyéthylène) à terminaison alkyloxy et des mélanges de ceux-ci ; - au moins un type d'unités structurelles C dérivées d'amines à encombrement stérique.
CA2963582A 2014-11-28 2015-11-20 Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal Active CA2963582C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZPV2014-825 2014-11-28
CZ2014-825A CZ305391B6 (cs) 2014-11-28 2014-11-28 Přípravek pro orální použití
PCT/CZ2015/050011 WO2016082808A1 (fr) 2014-11-28 2015-11-20 Préparation orale

Publications (2)

Publication Number Publication Date
CA2963582A1 CA2963582A1 (fr) 2016-06-02
CA2963582C true CA2963582C (fr) 2017-12-05

Family

ID=54054181

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2963582A Active CA2963582C (fr) 2014-11-28 2015-11-20 Preparation orale renfermant un polymere mucoadhesif, hydrophile, biocompatible destinee a la prevention et au traitement d'etats inflammatoires du tractus gastro-intestinal

Country Status (3)

Country Link
CA (1) CA2963582C (fr)
CZ (1) CZ305391B6 (fr)
WO (1) WO2016082808A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2018359A3 (cs) * 2018-07-17 2019-11-20 Ústav makromolekulární chemie AV ČR, v. v. i. Tekutý krycí přípravek pro ošetření ran

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ293419B6 (cs) * 1997-12-03 2004-04-14 Ústav Makromolekulární Chemie Av Čr Přípravek k prevenci a hojení zánětlivých onemocnění
CA2723118C (fr) * 2008-05-02 2016-05-17 University Of Tsukuba Compose radicalaire de nitroxyde cyclique polymerise et utilisation associee
CZ2008490A3 (cs) * 2008-08-15 2010-02-24 Labský@Jirí Synergický vliv benzofenonu a stericky stínených aminu pri lécení povrchových poranení
JP5850518B2 (ja) * 2010-11-22 2016-02-03 国立大学法人 筑波大学 高分子化環状ニトロキシドラジカル化合物の潰瘍性消化管の炎症の処置剤
JP2013173689A (ja) * 2012-02-24 2013-09-05 Univ Of Tsukuba 高分子化ニトロキシドラジカル化合物と非ステロイド性抗炎症薬の複合体

Also Published As

Publication number Publication date
WO2016082808A1 (fr) 2016-06-02
CZ2014825A3 (cs) 2015-08-26
CA2963582A1 (fr) 2016-06-02
CZ305391B6 (cs) 2015-08-26

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