CA2964168C - Inhibition therapeutique de la lactate-deshydrogenase et agents associes - Google Patents

Inhibition therapeutique de la lactate-deshydrogenase et agents associes

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Publication number
CA2964168C
CA2964168C CA2964168A CA2964168A CA2964168C CA 2964168 C CA2964168 C CA 2964168C CA 2964168 A CA2964168 A CA 2964168A CA 2964168 A CA2964168 A CA 2964168A CA 2964168 C CA2964168 C CA 2964168C
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CA
Canada
Prior art keywords
dsna
xxxxxxxxxxxxxxxxxxxxxxxdd
strand
xxxxxxxxxxxxxxxxxxxxxxxxxxx
nucleotides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2964168A
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English (en)
Other versions
CA2964168A1 (fr
Inventor
Bob D. Brown
Henryk T. Dudek
Cheng Lai
Original Assignee
Novo Nordisk Health Care AG
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Application filed by Novo Nordisk Health Care AG filed Critical Novo Nordisk Health Care AG
Priority claimed from PCT/US2015/054959 external-priority patent/WO2016057932A1/fr
Publication of CA2964168A1 publication Critical patent/CA2964168A1/fr
Application granted granted Critical
Publication of CA2964168C publication Critical patent/CA2964168C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne des composés, des compositions et des méthodes utilisés pour réduire les taux de protéines et d'ARN cibles de la lactate déshydrogénase au moyen de l'utilisation d'ARN bicaténaires, par exemple, d'agents de type ARNsi de substrat pour Dicer (ARNsiD).
CA2964168A 2014-10-10 2015-10-09 Inhibition therapeutique de la lactate-deshydrogenase et agents associes Active CA2964168C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462062424P 2014-10-10 2014-10-10
US62/062,424 2014-10-10
US201562199056P 2015-07-30 2015-07-30
US62/199,056 2015-07-30
PCT/US2015/054959 WO2016057932A1 (fr) 2014-10-10 2015-10-09 Inhibition thérapeutique de la lactate-déshydrogénase et agents associés

Publications (2)

Publication Number Publication Date
CA2964168A1 CA2964168A1 (fr) 2016-04-14
CA2964168C true CA2964168C (fr) 2025-08-12

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