CA2969089A1 - Procede de preparation d'une composition de polymere-medicament - Google Patents

Procede de preparation d'une composition de polymere-medicament Download PDF

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Publication number
CA2969089A1
CA2969089A1 CA2969089A CA2969089A CA2969089A1 CA 2969089 A1 CA2969089 A1 CA 2969089A1 CA 2969089 A CA2969089 A CA 2969089A CA 2969089 A CA2969089 A CA 2969089A CA 2969089 A1 CA2969089 A1 CA 2969089A1
Authority
CA
Canada
Prior art keywords
drug
polymer
preparation
polymer composition
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2969089A
Other languages
English (en)
Inventor
Kirit Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2969089A1 publication Critical patent/CA2969089A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une composition améliorée de polymère-ingrédient pharmaceutique actif ou inactif et son procédé de préparation. En particulier, la présente invention concerne une composition améliorée de polymère-ingrédient pharmaceutique actif ou inactif et son procédé de préparation, le monomère encapsulant des particules d'ingrédient pharmaceutique actif ou inactif au niveau moléculaire et, à l'aide d'un procédé de polymérisation contrôlée, le monomère devenant ledit revêtement polymère sur ledit ingrédient pharmaceutique actif ou inactif qui facilite la mise en uvre de la présente invention en une seule étape.
CA2969089A 2014-11-30 2015-11-26 Procede de preparation d'une composition de polymere-medicament Abandoned CA2969089A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2457MU2014 2014-11-30
IN2457/MUM/2014 2014-11-30
PCT/IN2015/050177 WO2016084105A1 (fr) 2014-11-30 2015-11-26 Procédé de préparation d'une composition de polymère-médicament

Publications (1)

Publication Number Publication Date
CA2969089A1 true CA2969089A1 (fr) 2016-06-02

Family

ID=55442843

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2969089A Abandoned CA2969089A1 (fr) 2014-11-30 2015-11-26 Procede de preparation d'une composition de polymere-medicament

Country Status (8)

Country Link
US (1) US10668019B2 (fr)
EP (1) EP3223799B1 (fr)
CN (1) CN106999442A (fr)
AU (1) AU2015351913B2 (fr)
CA (1) CA2969089A1 (fr)
ES (1) ES2778082T3 (fr)
PL (1) PL3223799T3 (fr)
WO (1) WO2016084105A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114353444A (zh) * 2022-01-14 2022-04-15 成都市海通药业有限公司 一种降低奥硝唑注射液中杂质b的方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2967689T3 (es) 2018-04-06 2024-05-03 Capsugel Belgium Nv Proceso de secado por aspersión para partículas de baja relación de aspecto que comprenden poli[(metacrilato de metilo)-co-(ácido metacrílico)]

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286489A (en) 1985-08-26 1994-02-15 The Procter & Gamble Company Taste masking compositions
US5084278A (en) 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
US5149775A (en) 1991-01-25 1992-09-22 Eastman Kodak Company Method for purifying high molecular weight vinylpyridine/styrene polymers from solution
JP2000508339A (ja) 1996-10-01 2000-07-04 シーマ・ラブス・インコーポレイテッド 味隠蔽マイクロカプセル組成物及び製造方法
US20050084540A1 (en) 2003-10-17 2005-04-21 Indranil Nandi Taste masking antibiotic composition
CN1878540B (zh) * 2003-12-15 2012-02-29 科学与工业研究委员会 含pH敏感性聚合物的掩味的药物组合物
WO2005056619A1 (fr) 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research Polymère sensible au ph et son procédé de fabrication
AU2003288706B2 (en) 2003-12-15 2007-08-23 Council Of Scientific And Industrial Research pH sensitive polymer and process for preparation thereof
EP1813268A1 (fr) * 2006-06-15 2007-08-01 DSMIP Assets B.V. Méthode pour la préparation des matrices polymeriques par radiation comprenant des agents actifs sensitifs
US20120076858A1 (en) 2009-06-04 2012-03-29 Basf Se Orally Disintegrating Dosage Forms Containing Taste-Masked Active Ingredients
EP2509631A4 (fr) 2009-12-10 2014-04-02 Monosol Rx Llc Composés sensibles au ph destinés à masquer le goût de bandelettes orales sous forme de film mince
BR112013033466A8 (pt) * 2011-06-27 2018-03-06 Cristal Delivery B V uso de um sistema de liberação controlada e sistema de liberação controlada
US20140056981A1 (en) 2012-08-21 2014-02-27 Centro De Investigacion En Quimica Aplicada Method for producing drug-loaded polymeric nanoparticles by polymerization in presence of drugs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114353444A (zh) * 2022-01-14 2022-04-15 成都市海通药业有限公司 一种降低奥硝唑注射液中杂质b的方法
CN114353444B (zh) * 2022-01-14 2023-01-03 成都市海通药业有限公司 一种降低奥硝唑注射液中杂质b的方法

Also Published As

Publication number Publication date
EP3223799A1 (fr) 2017-10-04
ES2778082T3 (es) 2020-08-07
PL3223799T3 (pl) 2020-06-15
AU2015351913A1 (en) 2017-03-09
US10668019B2 (en) 2020-06-02
US20170304205A1 (en) 2017-10-26
CN106999442A (zh) 2017-08-01
WO2016084105A1 (fr) 2016-06-02
AU2015351913B2 (en) 2021-07-15
EP3223799B1 (fr) 2019-12-18

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20201126

FZDE Discontinued

Effective date: 20230526