CA2971430C - Lymphocytes b pour l'administration in vivo d'agents therapeutiques - Google Patents

Lymphocytes b pour l'administration in vivo d'agents therapeutiques

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Publication number
CA2971430C
CA2971430C CA2971430A CA2971430A CA2971430C CA 2971430 C CA2971430 C CA 2971430C CA 2971430 A CA2971430 A CA 2971430A CA 2971430 A CA2971430 A CA 2971430A CA 2971430 C CA2971430 C CA 2971430C
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CA
Canada
Prior art keywords
cells
cell
cd40l
cell population
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2971430A
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English (en)
Other versions
CA2971430A1 (fr
Inventor
Matthew Rein Scholz
Eric J. Herbig
Mei Xu
Rian DE LAAT
Original Assignee
Immusoft Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Immusoft Corp filed Critical Immusoft Corp
Priority claimed from PCT/US2015/066908 external-priority patent/WO2016100932A1/fr
Publication of CA2971430A1 publication Critical patent/CA2971430A1/fr
Application granted granted Critical
Publication of CA2971430C publication Critical patent/CA2971430C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne des lymphocytes B génétiquement modifiés, notamment des lymphocytes mémoires, différenciés en plasmoblastes ou en plasmocytes utiles pour l'expression in vivo à long terme d'un transgène, tel qu'un anticorps spécifique ou un autre composé thérapeutique protéique. L'invention concerne également des procédés de production desdites cellules et des méthodes de traitement.
CA2971430A 2014-12-19 2015-12-18 Lymphocytes b pour l'administration in vivo d'agents therapeutiques Active CA2971430C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094794P 2014-12-19 2014-12-19
US62/094,794 2014-12-19
US201562110063P 2015-01-30 2015-01-30
US62/110,063 2015-01-30
PCT/US2015/066908 WO2016100932A1 (fr) 2014-12-19 2015-12-18 Lymphocytes b pour l'administration in vivo d'agents thérapeutiques

Publications (2)

Publication Number Publication Date
CA2971430A1 CA2971430A1 (fr) 2016-06-23
CA2971430C true CA2971430C (fr) 2025-08-12

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