CA2971858C - Composes, compositions et procedes pour augmenter l'activite du cftr - Google Patents

Composes, compositions et procedes pour augmenter l'activite du cftr

Info

Publication number
CA2971858C
CA2971858C CA2971858A CA2971858A CA2971858C CA 2971858 C CA2971858 C CA 2971858C CA 2971858 A CA2971858 A CA 2971858A CA 2971858 A CA2971858 A CA 2971858A CA 2971858 C CA2971858 C CA 2971858C
Authority
CA
Canada
Prior art keywords
cftr
mmol
carboxamide
cyclobutyl
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2971858A
Other languages
English (en)
Other versions
CA2971858A1 (fr
Inventor
Cecilia M. Bastos
Benito Munoz
Bradley Tait
Original Assignee
Proteostasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteostasis Therapeutics Inc filed Critical Proteostasis Therapeutics Inc
Priority claimed from PCT/US2015/000212 external-priority patent/WO2016105485A2/fr
Publication of CA2971858A1 publication Critical patent/CA2971858A1/fr
Application granted granted Critical
Publication of CA2971858C publication Critical patent/CA2971858C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente divulgation concerne des composés qui peuvent augmenter l'activité du régulateur de la perméabilité transmembranaire de la fibrose kystique (CFTR) telle que mesurée dans des cellules épithéliales bronchiques humaines (hBE). Plus précisément, la présente divulgation concerne des composés de formule (III) :
CA2971858A 2014-12-23 2015-12-23 Composes, compositions et procedes pour augmenter l'activite du cftr Active CA2971858C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462096374P 2014-12-23 2014-12-23
US62/096,374 2014-12-23
US201562102244P 2015-01-12 2015-01-12
US62/102,244 2015-01-12
US201562196839P 2015-07-24 2015-07-24
US62/196,839 2015-07-24
US201562199661P 2015-07-31 2015-07-31
US62/199,661 2015-07-31
PCT/US2015/000212 WO2016105485A2 (fr) 2014-12-23 2015-12-23 Composés, compositions et procédés pour augmenter l'activité du cftr

Publications (2)

Publication Number Publication Date
CA2971858A1 CA2971858A1 (fr) 2016-06-30
CA2971858C true CA2971858C (fr) 2025-10-21

Family

ID=

Similar Documents

Publication Publication Date Title
US11098035B2 (en) Compounds, compositions, and methods for increasing CFTR activity
US11083709B2 (en) Compounds, compositions, and methods of increasing CFTR activity
US10738040B2 (en) Compounds, compositions, and methods for increasing CFTR activity
AU2021215136A1 (en) Compounds, compositions, and methods for increasing CFTR activity
CA3078230A1 (fr) Composes, compositions et methodes pour augmenter l'activite de cftr
CA2971850A1 (fr) Derives d'amides 5-phenyl- ou 5-heteroarylthiazol-2-carboxyliques servant au traitement, entre autres, de la fibrose cystique
AU2015229117A1 (en) Compounds, compositions, and methods for increasing CFTR activity
WO2016105468A1 (fr) Dérivés de 3-hétéroarylisoxazol-5-amide carboxylique utiles dans le traitement, entre autres, d'une fibrose kystique
AU2015229188A1 (en) Compounds, compositions, and methods for increasing CFTR activity
WO2016115090A1 (fr) Composés, compositions et méthodes pour augmenter l'activité du cftr
CA2971858C (fr) Composes, compositions et procedes pour augmenter l'activite du cftr