CA2973484C - Furoquinolinediones servant d'inhibiteurs de tdp2 - Google Patents

Furoquinolinediones servant d'inhibiteurs de tdp2

Info

Publication number
CA2973484C
CA2973484C CA2973484A CA2973484A CA2973484C CA 2973484 C CA2973484 C CA 2973484C CA 2973484 A CA2973484 A CA 2973484A CA 2973484 A CA2973484 A CA 2973484A CA 2973484 C CA2973484 C CA 2973484C
Authority
CA
Canada
Prior art keywords
compound
c6alkyl
salt
halogen
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2973484A
Other languages
English (en)
Other versions
CA2973484A1 (fr
Inventor
Christophe Marchand
Yves Pommier
Linkun An
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
United States, AS REPRESENTED BY SECRETARY DEPARTMEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States, AS REPRESENTED BY SECRETARY DEPARTMEN filed Critical United States, AS REPRESENTED BY SECRETARY DEPARTMEN
Priority claimed from PCT/US2016/012672 external-priority patent/WO2016112304A1/fr
Publication of CA2973484A1 publication Critical patent/CA2973484A1/fr
Application granted granted Critical
Publication of CA2973484C publication Critical patent/CA2973484C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne des composés de formule I et les sels pharmaceutiquement acceptables de ceux-ci. Formule I. Les variables X1, X2 et R1-4 sont décrites dans cette invention. Lesdits composés sont utiles dans le traitement du cancer et de maladies prolifératives apparentées. L'invention concerne également des compositions pharmaceutiques contenant des composés de formule I et des procédés de traitement consistant à administrer des composés de formule I.
CA2973484A 2015-01-08 2016-01-08 Furoquinolinediones servant d'inhibiteurs de tdp2 Active CA2973484C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562100968P 2015-01-08 2015-01-08
US62/100,968 2015-01-08
PCT/US2016/012672 WO2016112304A1 (fr) 2015-01-08 2016-01-08 Furoquinolinediones servant d'inhibiteurs de tdp2

Publications (2)

Publication Number Publication Date
CA2973484A1 CA2973484A1 (fr) 2016-07-14
CA2973484C true CA2973484C (fr) 2025-12-09

Family

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