CA2984444C - Procede de preparation d'un agent anticancereux 1-((4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinoline-7-yloxy)methyl) cyclopropanamine, sa forme cristalline et ses sels - Google Patents

Procede de preparation d'un agent anticancereux 1-((4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinoline-7-yloxy)methyl) cyclopropanamine, sa forme cristalline et ses sels

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Publication number
CA2984444C
CA2984444C CA2984444A CA2984444A CA2984444C CA 2984444 C CA2984444 C CA 2984444C CA 2984444 A CA2984444 A CA 2984444A CA 2984444 A CA2984444 A CA 2984444A CA 2984444 C CA2984444 C CA 2984444C
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CA
Canada
Prior art keywords
yloxy
methyl
cyclopropanamine
fluoro
indol
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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CA2984444A
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English (en)
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CA2984444A1 (fr
Inventor
Guoqing Paul Chen
Changren Yan
Original Assignee
Advenchen Pharmaceuticals LLC
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Priority claimed from US15/143,630 external-priority patent/US9751859B2/en
Application filed by Advenchen Pharmaceuticals LLC filed Critical Advenchen Pharmaceuticals LLC
Publication of CA2984444A1 publication Critical patent/CA2984444A1/fr
Application granted granted Critical
Publication of CA2984444C publication Critical patent/CA2984444C/fr
Active legal-status Critical Current
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Abstract

La présente invention concerne un nouveau procédé de synthèse de 1-((4-(4-fluoro-2-méthyl-1H-indol-5-yloxy)-6-méthoxyquinoline-7-yloxy)méthyl)cyclopropanamine (AL3818). Une forme cristalline stable d'AL3818 a été préparée. Des sels et leurs formes cristallines d'AL3818 ont également été préparés. Des activités anticancéreuses et optométriques d'AL3818 et ses sels ont été également testées. Ce nouveau procédé a été décrit dans le schéma I.
CA2984444A 2015-05-04 2016-05-03 Procede de preparation d'un agent anticancereux 1-((4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-6-methoxyquinoline-7-yloxy)methyl) cyclopropanamine, sa forme cristalline et ses sels Active CA2984444C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562156734P 2015-05-04 2015-05-04
US62/156,734 2015-05-04
US201562205272P 2015-08-14 2015-08-14
US62/205,272 2015-08-14
US15/143,630 US9751859B2 (en) 2015-05-04 2016-05-02 Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
US15/143,630 2016-05-02
PCT/US2016/030483 WO2016179123A1 (fr) 2015-05-04 2016-05-03 Procédé de préparation d'un agent anticancéreux 1-((4-(4-fluoro-2-méthyl-1h-indol-5-yloxy)-6-méthoxyquinoline-7-yloxy)méthyl) cyclopropanamine, sa forme cristalline et ses sels

Publications (2)

Publication Number Publication Date
CA2984444A1 CA2984444A1 (fr) 2016-11-10
CA2984444C true CA2984444C (fr) 2025-09-09

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