CA2988523C - Composes agoniste d'ep4-bisphosphonate a liaison amide et leurs utilisations - Google Patents

Composes agoniste d'ep4-bisphosphonate a liaison amide et leurs utilisations

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Publication number
CA2988523C
CA2988523C CA2988523A CA2988523A CA2988523C CA 2988523 C CA2988523 C CA 2988523C CA 2988523 A CA2988523 A CA 2988523A CA 2988523 A CA2988523 A CA 2988523A CA 2988523 C CA2988523 C CA 2988523C
Authority
CA
Canada
Prior art keywords
compound
bone
agonist
conjugate
bisphosphonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2988523A
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English (en)
Other versions
CA2988523A1 (fr
Inventor
Marion THEVENIN
Gang Chen
Robert N. Young
Original Assignee
Simon Fraser University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Simon Fraser University filed Critical Simon Fraser University
Priority claimed from PCT/IB2016/053482 external-priority patent/WO2016199111A1/fr
Publication of CA2988523A1 publication Critical patent/CA2988523A1/fr
Application granted granted Critical
Publication of CA2988523C publication Critical patent/CA2988523C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne des conjugués agoniste de EP4-bisphosphonate ou composés associés et leurs utilisations. Lesdits conjugués ou composés associés peuvent être utilisés pour permettre la délivrance d'un agonise d'EP4 ou composé associé vers un site d'action souhaité, tel qu'un os. Des fractions de bisphosphonate, liées aux agonistes d'EP4 via des lieurs amide, ont été impliquées dans l'inhibition de la résorption osseuse et dans le ciblage des tissus osseux.
CA2988523A 2015-06-12 2016-06-13 Composes agoniste d'ep4-bisphosphonate a liaison amide et leurs utilisations Active CA2988523C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562175118P 2015-06-12 2015-06-12
US62/175,118 2015-06-12
PCT/IB2016/053482 WO2016199111A1 (fr) 2015-06-12 2016-06-13 Composés agoniste d'ep4-bisphosphonate à liaison amide et leurs utilisations

Publications (2)

Publication Number Publication Date
CA2988523A1 CA2988523A1 (fr) 2016-12-15
CA2988523C true CA2988523C (fr) 2025-07-22

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