CA2991297C - Dispositifs de perfusion in vitro vascularisee, procedes de fabrication, et applications de ceux-ci - Google Patents
Dispositifs de perfusion in vitro vascularisee, procedes de fabrication, et applications de ceux-ciInfo
- Publication number
- CA2991297C CA2991297C CA2991297A CA2991297A CA2991297C CA 2991297 C CA2991297 C CA 2991297C CA 2991297 A CA2991297 A CA 2991297A CA 2991297 A CA2991297 A CA 2991297A CA 2991297 C CA2991297 C CA 2991297C
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- CA
- Canada
- Prior art keywords
- cells
- perfusion
- network
- channels
- microcirculation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
L'invention concerne un modèle de micro-circulation in vitro adaptable authentique, qui est fourni en intégrant un réseau imprimé 3D de canaux de perfusion revêtus de cellules endothéliales, formé par l'intermédiaire de coulée sacrificielle dans une matrice de gel, avec un système micro-vasculaire adaptable d'origine affiné à partir de micro-vaisseaux d'origine ajoutés à la matrice de gel. Une adaptation vasculaire sensible présentée par la micro-circulation in vitro est physiologiquement pertinente. L'invention concerne des procédés de fabrication, des dispositifs, des modèles et des plates-formes d'investigation pour des applications pharmaceutiques, des études d'interaction de parenchyme de micro-vaisseau et de mécanisme vasculaire, et des stratégies de vascularisation pour des applications d'ingénierie tissulaire.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188803P | 2015-07-06 | 2015-07-06 | |
| US62/188,803 | 2015-07-06 | ||
| US201662279019P | 2016-01-15 | 2016-01-15 | |
| US62/279,019 | 2016-01-15 | ||
| PCT/US2016/041034 WO2017007786A1 (fr) | 2015-07-06 | 2016-07-06 | Dispositifs de perfusion in vitro vascularisée, procédés de fabrication, et applications de ceux-ci |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2991297A1 CA2991297A1 (fr) | 2017-01-12 |
| CA2991297C true CA2991297C (fr) | 2025-12-09 |
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