CA2995210C - Conjugues chelates a base de manganese pour l'imagerie par resonance magnetique moleculaire - Google Patents

Conjugues chelates a base de manganese pour l'imagerie par resonance magnetique moleculaire

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Publication number
CA2995210C
CA2995210C CA2995210A CA2995210A CA2995210C CA 2995210 C CA2995210 C CA 2995210C CA 2995210 A CA2995210 A CA 2995210A CA 2995210 A CA2995210 A CA 2995210A CA 2995210 C CA2995210 C CA 2995210C
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Prior art keywords
iii
alkyl
compound
independently selected
tbm
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CA2995210A
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CA2995210A1 (fr
Inventor
Eric M. Gale
Peter Caravan
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General Hospital Corp
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Priority claimed from PCT/US2016/046874 external-priority patent/WO2017027834A1/fr
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Abstract

La présente invention concerne des exemples de ligands de chélation métallique qui ont une affinité élevée pour le manganèse. Les complexes de métal résultants peuvent être utilisés en tant qu'agents de contraste pour IRM, et peuvent être fonctionnalisés avec des fractions qui se lient à eux ou provoquent un changement dans la relaxivité en présence de cibles biochimiques.
CA2995210A 2015-08-13 2016-08-12 Conjugues chelates a base de manganese pour l'imagerie par resonance magnetique moleculaire Active CA2995210C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562204519P 2015-08-13 2015-08-13
US62/204,519 2015-08-13
US201662356732P 2016-06-30 2016-06-30
US62/356,732 2016-06-30
PCT/US2016/046874 WO2017027834A1 (fr) 2015-08-13 2016-08-12 Conjugués chélatés à base de manganèse pour l'imagerie par résonance magnétique moléculaire

Publications (2)

Publication Number Publication Date
CA2995210A1 CA2995210A1 (fr) 2017-02-16
CA2995210C true CA2995210C (fr) 2024-09-10

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