CA2995361C - Sels d'un inhibiteur de lsd1 - Google Patents

Sels d'un inhibiteur de lsd1

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Publication number
CA2995361C
CA2995361C CA2995361A CA2995361A CA2995361C CA 2995361 C CA2995361 C CA 2995361C CA 2995361 A CA2995361 A CA 2995361A CA 2995361 A CA2995361 A CA 2995361A CA 2995361 C CA2995361 C CA 2995361C
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CA
Canada
Prior art keywords
salt
theta
compound
degrees
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2995361A
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English (en)
Other versions
CA2995361A1 (fr
Inventor
Qun Li
Yongchun Pan
Wayne Han
Ganfeng Cao
William Frietze
Zhongjiang Jia
Vaqar Sharief
Jiacheng Zhou
Original Assignee
Incyte Holdings Corp
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Application filed by Incyte Holdings Corp filed Critical Incyte Holdings Corp
Priority claimed from PCT/US2016/046497 external-priority patent/WO2017027678A1/fr
Publication of CA2995361A1 publication Critical patent/CA2995361A1/fr
Application granted granted Critical
Publication of CA2995361C publication Critical patent/CA2995361C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Abstract

La présente invention concerne des sels tosylate d'acide cyclobutanecarboxylique 1-{[4-(méthoxyméthyl)-4-({[(1R,2S)-2- phénylcyclopropyl]amino}méthyl)pipéridin-1-yl]méthyl}, des procédés de préparation de ceux-ci, et des intermédiaires utiles dans la préparation de ceux-ci; lesquels sels selon l'invention sont utiles dans le traitement des maladies associées à LSD1 ou médiées par LSD1, telles que le cancer.
CA2995361A 2015-08-12 2016-08-11 Sels d'un inhibiteur de lsd1 Active CA2995361C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562204105P 2015-08-12 2015-08-12
US62/204,105 2015-08-12
US201662326246P 2016-04-22 2016-04-22
US62/326,246 2016-04-22
PCT/US2016/046497 WO2017027678A1 (fr) 2015-08-12 2016-08-11 Sels d'un inhibiteur de lsd1

Publications (2)

Publication Number Publication Date
CA2995361A1 CA2995361A1 (fr) 2017-02-16
CA2995361C true CA2995361C (fr) 2025-09-23

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