CA2999209C - Traitement de maladies ou de troubles associes a l'age et endommageant l'adn - Google Patents

Traitement de maladies ou de troubles associes a l'age et endommageant l'adn

Info

Publication number
CA2999209C
CA2999209C CA2999209A CA2999209A CA2999209C CA 2999209 C CA2999209 C CA 2999209C CA 2999209 A CA2999209 A CA 2999209A CA 2999209 A CA2999209 A CA 2999209A CA 2999209 C CA2999209 C CA 2999209C
Authority
CA
Canada
Prior art keywords
neurons
homeoprotein
mice
dna
engrailed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2999209A
Other languages
English (en)
Other versions
CA2999209A1 (fr
Inventor
Alain Prochiantz
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Sorbonne Universite
College de France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut National de la Sante et de la Recherche Medicale INSERM, Sorbonne Universite, College de France filed Critical Centre National de la Recherche Scientifique CNRS
Priority claimed from PCT/EP2016/072675 external-priority patent/WO2017071889A1/fr
Publication of CA2999209A1 publication Critical patent/CA2999209A1/fr
Application granted granted Critical
Publication of CA2999209C publication Critical patent/CA2999209C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne l'utilisation d'une homéoprotéine ou un vecteur recombinant codant pour ladite protéine pour traiter ou prévenir un dommage à l'ADN, et/ou le vieillissement cellulaire. L'invention concerne en particulier l'utilisation de l'homéoprotéine engrailed pour le traitement de la maladie de Parkinson.
CA2999209A 2015-09-23 2016-09-23 Traitement de maladies ou de troubles associes a l'age et endommageant l'adn Active CA2999209C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15306482.9 2015-09-23
EP15306482 2015-09-23
PCT/EP2016/072675 WO2017071889A1 (fr) 2015-09-23 2016-09-23 Traitement de maladies ou de troubles associés à l'âge et endommageant l'adn

Publications (2)

Publication Number Publication Date
CA2999209A1 CA2999209A1 (fr) 2017-05-04
CA2999209C true CA2999209C (fr) 2026-01-27

Family

ID=

Similar Documents

Publication Publication Date Title
Bertrand et al. Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats
Iwasaki et al. Regulation of cellular senescence in type 2 diabetes mellitus: from mechanisms to clinical applications
Elsherbiny et al. ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy
Wang et al. Emerging molecular therapeutic targets for spinal cord injury
Xiaohong et al. CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress
EP3517133B1 (fr) Composition pharmaceutique contenant un inhibiteur de mtor pour le traitement de la dégénérescence maculaire
Lin et al. Neuregulin-1, a microvascular endothelial-derived protein, protects against myocardial ischemia-reperfusion injury
Zhang et al. miR-21-5p protects hippocampal neurons of epileptic rats via inhibiting STAT3 expression.
Pan et al. MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy
Yu et al. Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow
ES2464731T3 (es) Compuestos y procedimientos para reducir el reclutamiento y/o migración de células polimorfonucleares
US9587002B2 (en) Sequence of nucleotides and peptides GSE 24.2 of dyskerin, which can induce telomerase activity, method for obtaining same, therapeutic compositions and applications thereof
Sun et al. Photoreceptor protection against light damage by AAV-mediated overexpression of heme oxygenase-1
Dong et al. Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity
US20130197069A1 (en) Methods for treating stress induced emotional disorders
US20210379144A1 (en) Homeoproteins for use in the treatment of neurodegenerative disorders
Zhang et al. Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats
Francavilla et al. Transient GFER knockdown in vivo impairs liver regeneration after partial hepatectomy
KR20100005120A (ko) 클러스터린을 이용한 체중 조절 장애 관련 질환의 진단, 예방 또는 치료 방법
KR20220007085A (ko) 식도 협착 억제제
KR102118116B1 (ko) Foxp3 또는 이를 코딩하는 유전자를 포함하는 나노입자 및 이의 용도
US20150274815A1 (en) Treatment of central nervous system (cns) injury
Chen et al. Targeting neuronal HK2 alleviates glutamate neurotoxicity and MCAO-induced ischemic brain injury
Hadji et al. Autosomal and X-Linked Degenerative Ataxias: From Genetics to Promising Therapeutics
Szumny et al. Glaucoma-new possibilities, new research