CA3005029C - Modulateurs du recepteur active par protease de type 2 - Google Patents

Modulateurs du recepteur active par protease de type 2

Info

Publication number
CA3005029C
CA3005029C CA3005029A CA3005029A CA3005029C CA 3005029 C CA3005029 C CA 3005029C CA 3005029 A CA3005029 A CA 3005029A CA 3005029 A CA3005029 A CA 3005029A CA 3005029 C CA3005029 C CA 3005029C
Authority
CA
Canada
Prior art keywords
peptide
amino acid
certain embodiments
sequence
par2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3005029A
Other languages
English (en)
Other versions
CA3005029A1 (fr
Inventor
Richard Looby
Original Assignee
Oasis Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oasis Pharmaceuticals LLC filed Critical Oasis Pharmaceuticals LLC
Priority claimed from PCT/US2016/061489 external-priority patent/WO2017083618A1/fr
Publication of CA3005029A1 publication Critical patent/CA3005029A1/fr
Application granted granted Critical
Publication of CA3005029C publication Critical patent/CA3005029C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne des peptides qui comprennent un fragment muté d'un récepteur activé par protéase de type 2 (PAR2) de type sauvage. Ces peptides comprennent une fraction hydrophobe qui peut pénétrer la membrane cellulaire et agir en tant qu'antagoniste de PAR2. L'invention concerne également des compositions et des cellules comprenant lesdits peptides et des méthodes d'utilisation de ces peptides.
CA3005029A 2015-11-13 2016-11-11 Modulateurs du recepteur active par protease de type 2 Active CA3005029C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562255334P 2015-11-13 2015-11-13
US62/255,334 2015-11-13
PCT/US2016/061489 WO2017083618A1 (fr) 2015-11-13 2016-11-11 Modulateurs du récepteur activé par protéase de type 2

Publications (2)

Publication Number Publication Date
CA3005029A1 CA3005029A1 (fr) 2017-05-18
CA3005029C true CA3005029C (fr) 2025-09-23

Family

ID=

Similar Documents

Publication Publication Date Title
US11732027B2 (en) Protease-activated receptor-2 modulators
KR102068370B1 (ko) 심부전의 치료를 위한 합성 아펠린 모방체
TWI750725B (zh) 新穎脂肪酸及其於共軛至生物分子之用途
DK1948219T3 (en) VEGF analogs and methods for using
JP6501775B2 (ja) 心不全治療用の環状ポリペプチド
JP6505692B2 (ja) 心不全治療のためのジスルフィド環状ポリペプチド
US10913781B2 (en) Pepducin design and use
AU2019218786A1 (en) Cell-permeable stapled peptide modules for cellular delivery
US11572399B2 (en) Long-acting GIP peptide analogues
JP2009508885A (ja) 治療的介入のためのｙ４選択性レセプターアゴニスト
TW201425339A (zh) 用於治療心臟衰竭之合成線狀愛帕琳（ａｐｅｌｉｎ）模擬物
CN100425282C (zh) 用于治疗性干预的y2/y4选择性受体激动剂
CA3005029C (fr) Modulateurs du recepteur active par protease de type 2
JP2023508256A (ja) 血管新生および血管機能を阻害するオリゴペプチド