CA3009169C - Procedes de synthese pour la preparation de di(4-methylbenzenesulfonate) de 2-amino-3-methylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1-a]isoquinolein-2-yl
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Procedes de synthese pour la preparation de di(4-methylbenzenesulfonate) de 2-amino-3-methylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1-a]isoquinolein-2-yl
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CA3009169C
CA3009169CCA3009169ACA3009169ACA3009169CCA 3009169 CCA3009169 CCA 3009169CCA 3009169 ACA3009169 ACA 3009169ACA 3009169 ACA3009169 ACA 3009169ACA 3009169 CCA3009169 CCA 3009169C
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Prior art keywords
dimethoxy
pyrido
isoquinolin
hexahydro
isobutyl
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Application filed by Neurocrine Biosciences IncfiledCriticalNeurocrine Biosciences Inc
Priority claimed from PCT/US2016/068277external-prioritypatent/WO2017112857A1/fr
Publication of CA3009169A1publicationCriticalpatent/CA3009169A1/fr
Application grantedgrantedCritical
Publication of CA3009169CpublicationCriticalpatent/CA3009169C/fr
Des procédés sont décrits pour la préparation de (S)-(2R,3R,11bR)-3-isobutyle-9,10-diméthoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-yl 2-amino-3-méthylbutanoate-di(4-méthylbenzènesulfonate) ou un solvate, un hydrate ou une polymorphie connexes utiles dans le traitement des troubles des mouvements hyperkinétiques. (voir les processus ci-haut)
CA3009169A2015-12-232016-12-22Procedes de synthese pour la preparation de di(4-methylbenzenesulfonate) de 2-amino-3-methylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1-a]isoquinolein-2-yl
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Procédés de synthèse pour la préparation de di(4-méthylbenzènesulfonate) de 2-amino-3-méthylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-diméthoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1,-a]isoquinoléin-2-yl
Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate)
Procedes de synthese pour la preparation de di(4-methylbenzenesulfonate) de 2-amino-3-methylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1-a]isoquinolein-2-yl
SYNTHETIC METHOD FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE)
SYNTHETIC METHOD FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE)