CA3015138C - Conjugues d'amanitine - Google Patents

Conjugues d'amanitine

Info

Publication number
CA3015138C
CA3015138C CA3015138A CA3015138A CA3015138C CA 3015138 C CA3015138 C CA 3015138C CA 3015138 A CA3015138 A CA 3015138A CA 3015138 A CA3015138 A CA 3015138A CA 3015138 C CA3015138 C CA 3015138C
Authority
CA
Canada
Prior art keywords
linker
hdp
target
amatoxin
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3015138A
Other languages
English (en)
Other versions
CA3015138A1 (fr
Inventor
Christian Lutz
Jan Anderl
Christoph Muller
Werner Simon
Susanne Werner-Simon
Torsten HECHLER
Michael Kulke
Original Assignee
Heidelberg Pharma Research GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP16000511.2A external-priority patent/EP3222292A1/fr
Application filed by Heidelberg Pharma Research GmbH filed Critical Heidelberg Pharma Research GmbH
Publication of CA3015138A1 publication Critical patent/CA3015138A1/fr
Application granted granted Critical
Publication of CA3015138C publication Critical patent/CA3015138C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

L'invention concerne un conjugué comprenant (a) une amatoxine comprenant (i) un acide aminé 4 en position 6'-désoxy ; et (ii) un acide aminé 8 en position S-désoxy ; (b) une fraction de liaison à une cible ; et c) éventuellement une séquence de liaison liant ladite amatoxine et ladite fraction de liaison à une cible. L'invention concerne en outre une composition pharmaceutique contenant un tel conjugué.
CA3015138A 2016-03-03 2017-03-02 Conjugues d'amanitine Active CA3015138C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16000511.2 2016-03-03
EP16000511.2A EP3222292A1 (fr) 2016-03-03 2016-03-03 Conjugués d'amanitine
PCT/EP2017/054911 WO2017149077A1 (fr) 2016-03-03 2017-03-02 Conjugués d'amanitine

Publications (2)

Publication Number Publication Date
CA3015138A1 CA3015138A1 (fr) 2017-09-08
CA3015138C true CA3015138C (fr) 2025-08-12

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