CA3018520C - Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations - Google Patents

Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations Download PDF

Info

Publication number
CA3018520C
CA3018520C CA3018520A CA3018520A CA3018520C CA 3018520 C CA3018520 C CA 3018520C CA 3018520 A CA3018520 A CA 3018520A CA 3018520 A CA3018520 A CA 3018520A CA 3018520 C CA3018520 C CA 3018520C
Authority
CA
Canada
Prior art keywords
prostate cancer
sequence
erg
erg8
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3018520A
Other languages
English (en)
Other versions
CA3018520A1 (fr
Inventor
Albert Dobi
Gyorgy Petrovics
Taduru Sreenath
Shiv Srivastava
Chen Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Original Assignee
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henry M Jackson Foundation for Advancedment of Military Medicine Inc filed Critical Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Publication of CA3018520A1 publication Critical patent/CA3018520A1/fr
Application granted granted Critical
Publication of CA3018520C publication Critical patent/CA3018520C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Il est décrit des modifications de lexpression du gène ERG. Il est également décrit des isoformes et un promoteur du gène ERG qui contribuent au cancer de la prostate ou y sont associés. Finalement, il est décrit des compositions et des méthodes thérapeutiques de détection, de diagnostic, de pronostic et de traitement du cancer de la prostate, lesquelles compositions et méthodes thérapeutiques comprennent des biomarqueurs servant à détecter lexpression dau moins deux gènes parmi les suivants : PSA/KLK3; PMEPA1; NKX3.1; ODC1; AMD1; ERG.
CA3018520A 2006-10-10 2007-10-09 Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations Active CA3018520C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85025406P 2006-10-10 2006-10-10
US60/850,254 2006-10-10
US92950507P 2007-06-29 2007-06-29
US60/929,505 2007-06-29
CA2664630A CA2664630C (fr) 2006-10-10 2007-10-09 Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2664630A Division CA2664630C (fr) 2006-10-10 2007-10-09 Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations

Publications (2)

Publication Number Publication Date
CA3018520A1 CA3018520A1 (fr) 2008-05-29
CA3018520C true CA3018520C (fr) 2022-05-17

Family

ID=39430412

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3018520A Active CA3018520C (fr) 2006-10-10 2007-10-09 Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations
CA2664630A Active CA2664630C (fr) 2006-10-10 2007-10-09 Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2664630A Active CA2664630C (fr) 2006-10-10 2007-10-09 Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations

Country Status (6)

Country Link
US (4) US8541169B2 (fr)
EP (3) EP2074225B1 (fr)
JP (3) JP5470041B2 (fr)
AU (1) AU2007324128B2 (fr)
CA (2) CA3018520C (fr)
WO (1) WO2008063769A2 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69739909D1 (de) * 1996-03-26 2010-07-29 Michael S Kopreski Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
US8043835B1 (en) 1996-03-26 2011-10-25 Oncomedx, Inc. Methods for detecting and monitoring cancer using extracellular RNA
US20080261292A1 (en) * 1998-09-22 2008-10-23 Oncomedx, Inc. Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions
US20100159464A1 (en) * 2001-11-05 2010-06-24 Oncomedx, Inc. Method for Detection of DNA Methyltransferase RNA in Plasma and Serum
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US11105808B2 (en) 2004-11-12 2021-08-31 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
CA2814598A1 (fr) 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Fusion geniques recurrentes dans le cancer de la prostate
WO2007081385A2 (fr) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation dans la formation et le contrôle de nanoréacteurs
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2530167A1 (fr) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Dispositifs microfluidiques
EP2077912B1 (fr) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
CA3018520C (fr) 2006-10-10 2022-05-17 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations
JP2010508855A (ja) * 2006-11-08 2010-03-25 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌マーカーとしてのｓｐｉｎｋ１およびその使用
WO2008097559A2 (fr) 2007-02-06 2008-08-14 Brandeis University Manipulation de fluides et de réactions dans des systèmes microfluidiques
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
CA2692793C (fr) 2007-07-06 2014-05-20 The Regents Of The University Of Michigan Rearrangements de genes mipol1 -etv1
US20090136942A1 (en) * 2007-09-18 2009-05-28 Oncomedx, Inc. Analysis of Extracellular RNA
US8191002B2 (en) 2007-10-15 2012-05-29 International Business Machines Corporation Summarizing portlet usage in a portal page
CA2719172C (fr) * 2008-04-10 2020-08-25 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Alterations dans l'expression du gene erg specifiques du cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations
AU2009253675A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
EP4047367A1 (fr) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Procedé de détection d'analytes cibles au moyens des bibliothèques de gouttelettes
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010111231A1 (fr) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation de gouttelettes microfluidiques
BRPI1007620A2 (pt) 2009-05-12 2016-02-23 Koninkl Philips Electronics Nv fosfodoestera 9a,composição metodo,metodo de aquisição de dados e imunoesnsaio para diagnostico, detecção, monitoramento ou prognostico do cancer de proposta, ou para diagnostico,detecção monitoramento ou prognostico da progressao do cancer de prostata.
ES2700877T3 (es) 2009-05-12 2019-02-19 Koninklijke Philips Nv Fosfodiesterasa 4D7 como marcador de cáncer de próstata
EP2435584B1 (fr) 2009-05-26 2016-07-13 Quest Diagnostics Investments Incorporated Procédés de détection de dérèglements de gènes
EP2478120B1 (fr) 2009-09-17 2015-09-02 The Regents Of The University Of Michigan Fusions de gène récurrentes dans le cancer de la prostate
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US8546552B2 (en) 2009-12-23 2013-10-01 Quest Diagnostics Investments Incorporated TMPRSS2 for the diagnosis of prostate disease
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (fr) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Analyse numérique d'analyte
US20130143948A1 (en) * 2010-08-20 2013-06-06 Cedars-Sinai Medical Center Mst1 as a prognostic biomarker and therapeutic target in human cancer
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
EP3412778A1 (fr) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Procédés permettant de former des gouttelettes mélangées
WO2012112804A1 (fr) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions et méthodes de marquage moléculaire
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (fr) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Quantification d'enzyme
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US20140303034A1 (en) * 2011-12-09 2014-10-09 British Columbia Cancer Agency Branch Predicting prognosis in classic hodgkin lymphoma
WO2013120089A1 (fr) 2012-02-10 2013-08-15 Raindance Technologies, Inc. Dosage de type criblage diagnostique moléculaire
EP2844768B1 (fr) 2012-04-30 2019-03-13 Raindance Technologies, Inc. Analyse d'analyte numérique
EP2885640B1 (fr) 2012-08-16 2018-07-18 Genomedx Biosciences, Inc. Prognostic du cancer de la prostate au moyen de biomarqueurs
JP6044935B2 (ja) 2013-03-11 2016-12-14 学校法人日本大学 新規ｐｉポリアミド
WO2014172288A2 (fr) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Analyse d'analyte numérique
EP3046577A4 (fr) * 2013-09-20 2017-04-05 Landegren, Nils Nouvel auto-antigène
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (fr) 2013-12-31 2015-07-09 Raindance Technologies, Inc. Système et procédé de détection d'une espèce d'arn
WO2015138722A1 (fr) * 2014-03-12 2015-09-17 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Nouveaux inhibiteurs de cancers positifs vis-à-vis de l'oncogène erg
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US20190204322A1 (en) * 2015-09-09 2019-07-04 Genomedx Biosciences, Inc. Molecular subtyping, prognosis and treatment of prostate cancer
WO2017061128A1 (fr) 2015-10-08 2017-04-13 凸版印刷株式会社 Procédé et trousse de concentration de molécules d'acide nucléique double brin cibles utilisant du polyamide pyrrole-imidazole
EP3504348B1 (fr) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Utilisation de signatures génomiques en vue d'une prédiction de la réactivité de patients atteints d'un cancer de la prostate à une radiothérapie postopératoire
WO2018132916A1 (fr) 2017-01-20 2018-07-26 Genomedx Biosciences, Inc. Sous-typage moléculaire, pronostic et traitement du cancer de la vessie
CA3055925A1 (fr) 2017-03-09 2018-09-13 Decipher Biosciences, Inc. Sous-typage du cancer de la prostate pour predire la reponse a une therapie hormonale
AU2018266733A1 (en) 2017-05-12 2020-01-16 Veracyte, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
WO2019028285A2 (fr) 2017-08-04 2019-02-07 Genomedx, Inc. Utilisation d'une expression génique spécifique des cellules immunitaires pour le pronostic du cancer de la prostate et la prédiction de la sensibilité à la radiothérapie
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
CA2092323A1 (fr) 1990-10-01 1992-04-02 George Y. Wu Ciblage de virus et de cellules pour internalisation selective par les cellules
CA2103064A1 (fr) 1991-05-14 1992-11-15 George Y. Wu Administration ciblee de genes codant pour des proteines immunogenes
DK0587738T3 (da) 1991-06-05 2000-12-18 Univ Connecticut Destineret levering af gener, som koder for sekretionsproteiner
AU3434393A (en) 1992-01-17 1993-08-03 Regents Of The University Of Michigan, The Targeted virus
EP0633943A4 (fr) 1992-04-03 1997-05-02 Alexander T Young Therapie genique utilisant des vecteurs viraux cibles.
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US8048629B2 (en) * 1996-03-15 2011-11-01 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
US6054316A (en) 1999-06-25 2000-04-25 Isis Pharmaceuticals Inc. Antisense inhibition of ETs-2 expression
WO2001029262A2 (fr) 1999-10-15 2001-04-26 Orchid Biosciences, Inc. Reactifs de genotypage, kits et procedes d'utilisation desdits reactifs
AU3087801A (en) 2000-02-04 2001-08-14 Molecular Dynamics Inc Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
IL154129A0 (en) 2000-07-28 2003-07-31 Compugen Inc Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome
DE10057755A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Phosphomevalonat Kinasen aus Pflanzen
US7892730B2 (en) 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US20030148519A1 (en) 2001-11-14 2003-08-07 Engelke David R. Intracellular expression and delivery of siRNAs in mammalian cells
EP1474512A2 (fr) * 2002-02-13 2004-11-10 Axordia Limited Cellules souches pluripotentielles
HUE026218T2 (en) * 2002-02-21 2016-05-30 Inst Virology MN / CA IX-Specific Monoclonal Antibodies and Methods for MN / CA IX Deficient Mice
US20040241707A1 (en) * 2002-04-01 2004-12-02 Gao Chun L. Enhanced diagnostic potential of prostate-specific antigen expressing cells
US7217807B2 (en) 2002-11-26 2007-05-15 Rosetta Genomics Ltd Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
US20040181821A1 (en) 2003-03-14 2004-09-16 Jiadong Zhou siRNA research tool kit
US20070048738A1 (en) * 2003-07-14 2007-03-01 Mayo Foundation For Medical Education And Research Methods and compositions for diagnosis, staging and prognosis of prostate cancer
US20060058255A1 (en) 2004-03-01 2006-03-16 Jianzhu Chen RNAi-based therapeutics for allergic rhinitis and asthma
US7374927B2 (en) 2004-05-03 2008-05-20 Affymetrix, Inc. Methods of analysis of degraded nucleic acid samples
US10066268B2 (en) * 2004-05-07 2018-09-04 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of diagnosing or treating prostate cancer using the ERG gene, alone or in combination with other over or under expressed genes in prostate cancer
JP5697297B2 (ja) * 2004-05-14 2015-04-08 ロゼッタ ジノミクス リミテッド マイクロｎａｓおよびその使用
CA2814598A1 (fr) * 2005-09-12 2007-03-22 The Regents Of The University Of Michigan Fusion geniques recurrentes dans le cancer de la prostate
CA3018520C (fr) * 2006-10-10 2022-05-17 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations

Also Published As

Publication number Publication date
JP2010505446A (ja) 2010-02-25
US20150044670A1 (en) 2015-02-12
EP2074225B1 (fr) 2014-12-03
CA3018520A1 (fr) 2008-05-29
JP5470041B2 (ja) 2014-04-16
EP2074225A2 (fr) 2009-07-01
US9206481B2 (en) 2015-12-08
EP2518163A2 (fr) 2012-10-31
EP2837697A2 (fr) 2015-02-18
JP2016165270A (ja) 2016-09-15
EP2837697A3 (fr) 2015-02-25
AU2007324128A1 (en) 2008-05-29
WO2008063769A3 (fr) 2008-12-18
US20160115481A1 (en) 2016-04-28
EP2837697B1 (fr) 2016-12-07
CA2664630C (fr) 2018-11-27
EP2518163A3 (fr) 2013-02-06
EP2518163B1 (fr) 2014-08-06
JP2014113162A (ja) 2014-06-26
US20100144832A1 (en) 2010-06-10
US8541169B2 (en) 2013-09-24
JP6383743B2 (ja) 2018-08-29
US20080269157A1 (en) 2008-10-30
WO2008063769A9 (fr) 2008-07-10
US10287587B2 (en) 2019-05-14
AU2007324128B2 (en) 2013-10-10
WO2008063769A2 (fr) 2008-05-29
CA2664630A1 (fr) 2008-05-29
JP6078484B2 (ja) 2017-02-08

Similar Documents

Publication Publication Date Title
CA3018520C (fr) Alterations de l'expression du gene erg specifiques au cancer de la prostate, et procedes de detection et de traitement en fonction de ces alterations
EP2740742B1 (fr) Gène chimère de gène kif5b et de gène ret, et procédé de détermination de l'efficacité d'un traitement anticancéreux ciblant le gène chimère
EP3018216B1 (fr) Fusions de gène récurrentes dans le cancer de la prostate
EP2288722B1 (fr) Altérations dans l'expression du gène erg spécifiques du cancer de la prostate et procédés de dépistage et de traitement basés sur ces altérations
US20060194199A1 (en) Method for diagnosing testicular seminomas
CA2726531A1 (fr) Compositions et procedes pour la classification du cancer du poumon et le pronostic de survie au cancer du poumon
AU2016222467B2 (en) Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations
AU2014200037B2 (en) Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180925