CA3020214C - Recepteurs des lymphocytes t - Google Patents

Recepteurs des lymphocytes t

Info

Publication number
CA3020214C
CA3020214C CA3020214A CA3020214A CA3020214C CA 3020214 C CA3020214 C CA 3020214C CA 3020214 A CA3020214 A CA 3020214A CA 3020214 A CA3020214 A CA 3020214A CA 3020214 C CA3020214 C CA 3020214C
Authority
CA
Canada
Prior art keywords
seq
tcr
amino acid
acid sequence
variable domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3020214A
Other languages
English (en)
Other versions
CA3020214A1 (fr
Inventor
Conor Hayes
Linda HIBBERT
Nathaniel LIDDY
Tara MAHON
Marine RAMAN
Original Assignee
Immunocore Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunocore Ltd filed Critical Immunocore Ltd
Priority claimed from PCT/GB2017/050985 external-priority patent/WO2017175006A1/fr
Publication of CA3020214A1 publication Critical patent/CA3020214A1/fr
Application granted granted Critical
Publication of CA3020214C publication Critical patent/CA3020214C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne des récepteurs de lymphocytes T (TCR) qui se lient au peptide à restriction HLA-A*02 GVYDGREHTV (SEQ ID NO : 1) dérivé de l'antigène de cancer de lignée germinale MAGE A4. Ces TCR peuvent comprendre des mutations non naturelles dans les domaines variables alpha et/ou bêta par rapport à un TCR de MAGE A4 natif. Les TCR de l'invention sont particulièrement aptes à être utilisés en tant que nouveaux réactifs immunothérapeutiques pour le traitement de maladies malignes.
CA3020214A 2016-04-08 2017-04-07 Recepteurs des lymphocytes t Active CA3020214C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201606009 2016-04-08
GB1606009.7 2016-04-08
PCT/GB2017/050985 WO2017175006A1 (fr) 2016-04-08 2017-04-07 Récepteurs des lymphocytes t

Publications (2)

Publication Number Publication Date
CA3020214A1 CA3020214A1 (fr) 2017-10-12
CA3020214C true CA3020214C (fr) 2025-09-09

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