CA3029136C - Anticorps humanises franchissant la barriere hematoencephalique et leurs utilisations - Google Patents

Anticorps humanises franchissant la barriere hematoencephalique et leurs utilisations

Info

Publication number
CA3029136C
CA3029136C CA3029136A CA3029136A CA3029136C CA 3029136 C CA3029136 C CA 3029136C CA 3029136 A CA3029136 A CA 3029136A CA 3029136 A CA3029136 A CA 3029136A CA 3029136 C CA3029136 C CA 3029136C
Authority
CA
Canada
Prior art keywords
fragment
antibody
isolated
purified antibody
brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3029136A
Other languages
English (en)
Other versions
CA3029136A1 (fr
Inventor
Traian Sulea
Yves Durocher
Danica Stanimirovic
Kristin Kemmerich
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Priority claimed from PCT/IB2017/054036 external-priority patent/WO2018007950A1/fr
Publication of CA3029136A1 publication Critical patent/CA3029136A1/fr
Application granted granted Critical
Publication of CA3029136C publication Critical patent/CA3029136C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

La présente invention concerne des anticorps et des fragments correspondants obtenus par humanisation d'un anticorps existant, et leurs procédés de fabrication. Les anticorps humanisés selon l'invention présentent une plus forte liaison à l'antigène des cellules endothéliales cérébrales, une meilleure aptitude à franchir la barrière hématoencéphalique, et une plus grande stabilité thermique par rapport à l'anticorps parent non humanisé.
CA3029136A 2016-07-06 2017-07-04 Anticorps humanises franchissant la barriere hematoencephalique et leurs utilisations Active CA3029136C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662358777P 2016-07-06 2016-07-06
US62/358,777 2016-07-06
PCT/IB2017/054036 WO2018007950A1 (fr) 2016-07-06 2017-07-04 Anticorps humanisés franchissant la barrière hématoencéphalique et leurs utilisations

Publications (2)

Publication Number Publication Date
CA3029136A1 CA3029136A1 (fr) 2018-01-11
CA3029136C true CA3029136C (fr) 2025-11-18

Family

ID=

Similar Documents

Publication Publication Date Title
US10738115B2 (en) Humanized antibodies transmigrating the blood-brain barrier and uses thereof
US10112998B2 (en) Insulin-like growth factor 1 receptor-specific antibodies and uses thereof
US10106614B2 (en) Insulin-like growth factor 1 receptor-specific antibodies and uses thereof
US10100117B2 (en) Insulin-like growth factor 1 receptor-specific antibodies and uses thereof
US10906973B2 (en) Antibody variants transmigrating the blood-brain barrier and uses thereof
CA3029136C (fr) Anticorps humanises franchissant la barriere hematoencephalique et leurs utilisations
CA3046906C (fr) Variants d'anticorps franchissant la barriere hemato-encephalique et leurs utilisations
HK1233271B (en) Insulin-like growth factor 1 receptor -specific antibodies and uses thereof
HK1231906B (en) Insulin-like growth factor 1 receptor -specific antibodies and uses thereof
HK1233271A1 (en) Insulin-like growth factor 1 receptor -specific antibodies and uses thereof