CA3035860A1 - Pyridine compound - Google Patents

Pyridine compound Download PDF

Info

Publication number
CA3035860A1
CA3035860A1 CA3035860A CA3035860A CA3035860A1 CA 3035860 A1 CA3035860 A1 CA 3035860A1 CA 3035860 A CA3035860 A CA 3035860A CA 3035860 A CA3035860 A CA 3035860A CA 3035860 A1 CA3035860 A1 CA 3035860A1
Authority
CA
Canada
Prior art keywords
compound
cancer
pharmaceutically acceptable
acceptable salt
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3035860A
Other languages
English (en)
French (fr)
Inventor
Hiroaki Inagaki
Yoshihiro Shibata
Hidenori Namiki
Hideaki KAGEJI
Kiyoshi Nakayama
Yasuyuki Kaneta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CA3035860A1 publication Critical patent/CA3035860A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA3035860A 2016-09-29 2017-09-28 Pyridine compound Pending CA3035860A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016191725A JP2018052878A (ja) 2016-09-29 2016-09-29 ピリジン化合物
JP2016-191725 2016-09-29
PCT/GB2017/052913 WO2018060714A1 (en) 2016-09-29 2017-09-28 Pyridine compound

Publications (1)

Publication Number Publication Date
CA3035860A1 true CA3035860A1 (en) 2018-04-05

Family

ID=60020249

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3035860A Pending CA3035860A1 (en) 2016-09-29 2017-09-28 Pyridine compound

Country Status (33)

Country Link
US (2) US10851092B2 (sr)
EP (2) EP3519398B1 (sr)
JP (2) JP2018052878A (sr)
KR (1) KR102520543B1 (sr)
CN (2) CN113788824A (sr)
AU (2) AU2017335242C1 (sr)
BR (1) BR112019006047A2 (sr)
CA (1) CA3035860A1 (sr)
CL (1) CL2019000844A1 (sr)
CO (1) CO2019004034A2 (sr)
CY (1) CY1123988T1 (sr)
DK (1) DK3519398T3 (sr)
EA (1) EA037103B1 (sr)
EC (1) ECSP19030134A (sr)
ES (1) ES2868748T3 (sr)
HR (1) HRP20210447T1 (sr)
HU (1) HUE054824T2 (sr)
IL (1) IL265630B (sr)
LT (1) LT3519398T (sr)
MA (2) MA46337B1 (sr)
MD (1) MD3519398T2 (sr)
MX (1) MX2019003747A (sr)
PE (1) PE20190805A1 (sr)
PH (1) PH12019500480A1 (sr)
PL (1) PL3519398T3 (sr)
PT (1) PT3519398T (sr)
RS (1) RS61640B1 (sr)
SG (1) SG11201901937WA (sr)
SI (1) SI3519398T1 (sr)
SM (1) SMT202100315T1 (sr)
UA (1) UA123964C2 (sr)
WO (1) WO2018060714A1 (sr)
ZA (1) ZA201902232B (sr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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NZ742351A (en) 2015-11-02 2023-03-31 Blueprint Medicines Corp Inhibitors of ret
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
EP3773589B1 (en) 2018-04-03 2023-11-01 Blueprint Medicines Corporation Ret inhibitor for use in treating cancer having a ret alteration
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
US20230019999A1 (en) * 2019-11-18 2023-01-19 Chugai Seiyaku Kabushiki Kaisha Combination drug
CN113121524B (zh) 2019-12-31 2023-04-25 南京创济生物医药有限公司 杂环亚砜亚胺化合物及其中间体、制备方法和应用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021164741A1 (zh) * 2020-02-20 2021-08-26 南京明德新药研发有限公司 苯基双酰胺类化合物
ES3061427T3 (en) * 2020-02-20 2026-04-01 Guangzhou Baiyunshan Pharmaceutical Holdings Co Ltd Baiyunshan Pharmaceutical General Factory Quinoline compounds
CA3183728A1 (en) 2020-05-29 2021-12-02 Blueprint Medicines Corporation Solid forms of pralsetinib
WO2022238706A1 (en) 2021-05-14 2022-11-17 Bp Asset Viii, Inc. Ret inhibitor for the treatment of ret altered medullary thyroid cancer or ret altered non-small cell lung cancer
AU2022463015A1 (en) 2021-10-22 2024-05-09 Tract Pharmaceuticals, Inc. Methods and compositions for treating chronic inflammatory injury, metaplasia, dysplasia and cancers of epithelial tissues
CN115090331B (zh) * 2022-07-21 2023-05-16 扬州大学 超分子手性催化剂、其制备方法及其催化d-a反应的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
WO2007099323A2 (en) 2006-03-02 2007-09-07 Astrazeneca Ab Quinoline derivatives
WO2007099317A1 (en) 2006-03-02 2007-09-07 Astrazeneca Ab Quinazoline derivatives
WO2007113548A1 (en) 2006-04-06 2007-10-11 Astrazeneca Ab Naphthyridine derivatives
WO2007113565A1 (en) 2006-04-06 2007-10-11 Astrazeneca Ab Naphthyridine derivatives as anti-cancer agents
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
BRPI1008308B8 (pt) * 2009-02-27 2021-05-25 Teijin Pharma Ltd processo para produzir um composto
BR112012003661A2 (pt) 2009-08-19 2017-04-25 Ambit Biosciences Corp "compostos de biarila e métodos de uso dos mesmos."
JP2013503174A (ja) 2009-08-25 2013-01-31 アブラクシス バイオサイエンス， エルエルシー タキサンおよびヘッジホッグ阻害剤のナノ粒子組成物を使用する併用療法
JP2013527159A (ja) 2010-04-23 2013-06-27 キネタ・インコーポレイテツド 抗ウイルス性化合物
EP2651930B1 (en) 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Biarylamide inhibitors of leukotriene production
WO2014012050A2 (en) 2012-07-13 2014-01-16 Indiana University Research & Technology Corporation Compounds for treatment of spinal muscular atrophy
UY35465A (es) 2013-03-15 2014-10-31 Glaxosmithkline Ip Dev Ltd Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret)
CN105683182A (zh) * 2013-08-30 2016-06-15 埃姆比特生物科学公司 联芳基乙酰胺化合物及其使用方法
GB201321146D0 (en) 2013-11-29 2014-01-15 Cancer Rec Tech Ltd Quinazoline compounds
WO2015163435A1 (ja) * 2014-04-24 2015-10-29 田辺三菱製薬株式会社 新規２－アミノ－ピリジン及び２－アミノ－ピリミジン誘導体及びその医薬用途
AU2015313841B2 (en) * 2014-09-10 2018-03-08 Glaxosmithkline Intellectual Property Development Limited Pyridone derivatives as rearranged during transfection (RET) kinase inhibitors
CR20170094A (es) * 2014-09-10 2017-05-08 Glaxosmithkline Ip Dev Ltd Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret)
CN107427506A (zh) 2014-10-14 2017-12-01 拉霍拉敏感及免疫学研究所 低分子量蛋白酪氨酸磷酸酶的抑制剂及其用途
CN104844589B (zh) 2014-12-26 2018-04-20 中国科学院合肥物质科学研究院 一种pi3k激酶抑制剂
WO2016127074A1 (en) * 2015-02-06 2016-08-11 Blueprint Medicines Corporation 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors
HUE053067T2 (hu) 2015-07-16 2021-06-28 Array Biopharma Inc Helyettesített pirazolo[1,5-A]piridin vegyületek, mint RET kináz inhibitorok
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物

Also Published As

Publication number Publication date
SI3519398T1 (sl) 2021-07-30
CN110036007B (zh) 2021-10-15
EP3519398A1 (en) 2019-08-07
MD3519398T2 (ro) 2021-05-31
IL265630A (en) 2019-05-30
PL3519398T3 (pl) 2021-06-28
CO2019004034A2 (es) 2019-07-10
AU2017335242C1 (en) 2021-12-09
PE20190805A1 (es) 2019-06-10
RS61640B1 (sr) 2021-04-29
MA54910A (fr) 2022-04-13
CY1123988T1 (el) 2022-05-27
SMT202100315T1 (it) 2021-07-12
HRP20210447T1 (hr) 2021-07-23
ES2868748T3 (es) 2021-10-21
PT3519398T (pt) 2021-03-24
JP2019534871A (ja) 2019-12-05
MX2019003747A (es) 2019-09-19
BR112019006047A2 (pt) 2019-06-25
US10851092B2 (en) 2020-12-01
EA201990833A1 (ru) 2019-10-31
PH12019500480A1 (en) 2019-08-05
AU2017335242A1 (en) 2019-05-02
AU2017335242B2 (en) 2021-08-19
UA123964C2 (uk) 2021-06-30
ZA201902232B (en) 2022-12-21
EA037103B1 (ru) 2021-02-05
CN110036007A (zh) 2019-07-19
EP3828178A1 (en) 2021-06-02
MA46337A (fr) 2019-08-07
SG11201901937WA (en) 2019-04-29
LT3519398T (lt) 2021-05-10
EP3519398B1 (en) 2021-02-24
IL265630B (en) 2021-10-31
CN113788824A (zh) 2021-12-14
DK3519398T3 (da) 2021-03-29
HUE054824T2 (hu) 2021-10-28
AU2021261899A1 (en) 2021-12-02
KR102520543B1 (ko) 2023-04-10
CL2019000844A1 (es) 2019-06-07
MA46337B1 (fr) 2021-04-30
US20200039974A1 (en) 2020-02-06
WO2018060714A1 (en) 2018-04-05
US20210163464A1 (en) 2021-06-03
JP2018052878A (ja) 2018-04-05
JP7098609B2 (ja) 2022-07-11
KR20190086442A (ko) 2019-07-22
ECSP19030134A (es) 2019-08-30

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Effective date: 20220926